In modern terms of housekeeping complicated by coronavirus infection and crisis phenomena in world and Russian economics, there is a high probability of different risks occurrence, connected with activity of modern enterprises in investment and construction sphere. Success, profit and efficiency of enterprise activity in current situation in many ways depends on ability to manage appearing risks to minimize them. It confirms relevance of the research which results are performed in this article. Purpose of the research is to reveal priority directions of management actions aimed to production, financial, logistics, investment and other processes functioning in regional investment and construction sphere, and also to develop mechanism of risk management, which allows to provide reducing of risk appearance probability and minimize their effects. Authors have assessed state Irkutsk region’s investment and construction complex, determined the most likely risks of construction activity. It has been determined the essence of “risk” concept, and systematization of risks in investment and construction processes has been implemented. Mechanism of construction enterprise’s risk management has been developed. The methodological base for research are general scientific methods of understanding the processes of construction products: observation, generalization, comparison, grouping, as well as methods of logical, economical and system analysis.