Due to the complexity of the nail salon work environment, traditional approaches to exposure assessment in this context tend to mischaracterize potential hazards as nuisances. For this investigation, a workable “indoor air” approach was devised to characterize potential hazards and ventilation in Boston, Massachusetts area nail salons which are primarily owned and staffed by Vietnamese immigrants. A community-university partnership project recruited salons to participate in a short audit which included carbon dioxide measurements and evaluation of other air quality metrics. Twenty-two salons participated. Seventy-three percent of the salons had spot carbon dioxide measurements in excess of 700 ppm, the level corresponding to a ventilation rate recommended for beauty salons. Fourteen salons (64%) did not have a mechanical ventilation system to provide fresh air and/or exhaust contaminated air. The lack of adequate ventilation is of significant concern because of the presence of potentially hazardous chemicals in salon products and the common self-report of symptoms among nail technicians. Community and worker health may be improved through adoption of recommended ventilation guidelines and reduction in the hazard potential of nail products.