Results of a 16-week safety assurance study with rats fed genetically modified Bt maize: effect on growth and health parameters

Szymczyk, B.; Szczurek, W.; Świątkiewicz, Sylwester; Kwiatek, K.; Sieradzki, Z.; Mazur, Małgorzata; Bednarek, D.; Reichert, M.

doi:10.2478/jvetres-2018-0060

Cited by 8 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systematic evaluation of potential side effects of Bt-maize versus conventional maize have been carried out to assess any significant differences using animal feeding studies. These studies concluded that the Bt-maize was as safe and nutritious as existing conventional corn varieties 4,13,14 . However, these results were questioned by the Séralini lab 15 who after reanalysis of Monsanto’s data announced that the results of the three GMO studies were sex- and often dose-dependent and showed side effects associated with the kidney and liver, although these were not consistent between the three studies.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810

Stein

Ran

Bohmer

et al. 2019

Sci Rep

View full text Add to dashboard Cite

In a recent one-year feeding study, we observed no adverse effects on tissue level in organs of rats fed with the genetically-modified maize MON810. Here, we assessed RNA expression levels of 86 key genes of the apoptosis-, NF-кB-, DNA-damage response (DDR)-, and unfolded-protein response (UPR) pathways by RT-qPCR in the rat liver. Male and female rats were fed either with 33% MON810 (GMO), isogenic- (ISO), or conventional maize (CONV) and RNAs were quantified from eight rats from each of the six feeding groups. Only Birc2 transcript showed a significant (p ≤ 0.05) consistent difference of ≥1.5-fold between the GMO and ISO groups in both sexes. Unsupervised cluster analysis showed a strong separation of male and female rats, but no clustering of the feeding groups. Individual analysis of the pathways did not show any clustering of the male or female feeding groups either, though transcript levels of UPR pathway-associated genes caused some clustering of the male GMO and CONV feeding group samples. These differences were not seen between the GMO and ISO control or within the female cohort. Our data therefore does not support an adverse effect on rat liver RNA expression through the long-term feeding of MON810 compared to isogenic control maize.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Over the last years, numerous research activities have focused on the safety assessment of such genetically modified crops, using various animal models, including mouse 3 , rat 4–7 , cattle 8 , salmon 9 , poultry 7,10 and pig 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810

Stein

Ran

Bohmer

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Scholtz et al (2010) found no deterioration of the immune system in quail when fed on genetically modified maize. The experiment Szymczyk et al (2018) Indicators metabolism in rats fed a diet with conventional or genetically modified (MON 810) maize for 16 weeks was similar. The authors also no found significant differences in the body weight and the relative weight of the organs of rats, some histopathological changes in the liver, kidney and spleen were not related to nutrition.…”

Section: Introductionmentioning

confidence: 91%

Effect of GM maize on metabolism and performance of chicken

Gaviley

Pankova

Katerynych

2021

Acta fytotechn zootechn

View full text Add to dashboard Cite

Licensed under a Creative Commons Attribution 4.0 International License Genetically modified (GM) maize and conventional maize were tested experimentally to determine their effect on chicken serum biochemical parameters and metabolism. A total of 600 one day old parent stock chickens of breed White Plymouth Rock were divided into 2 experimental groups: K -diet based on traditional maize (control); D -a diet based on GM maize (experimental). During the experimental period (17 weeks), population vibility and feed consumption were monitored daily. At the age of 4, 8 and 17 weeks all birds were individually weighed. Blood samples for biochemical analyses were collected from chickens at 4 weeks and 12 weeks of age (n = 6). Analytical studies did not show significant changes in biochemical serum parameters in group D chickens. A significant difference between the groups of chickens receiving GM and traditional maize was found only by the content of lipids after 4 weeks (P <0.05) and cholesterol after 12 weeks of the experiment (P <0.05). Also noted increasing level of circulating immune complexes in serum of chickens that consumed feed from GM maize relative control at 32.2% (P <0.05) after 4 weeks of the experiment. However, the studied indicators of metabolism and immune response in birds were within the physiological range. Certain fluctuations in the parameters during the experiment were observed in both groups, which indicates that there is no connection between this fact and the feeding factor. In addition, optimal results were obtained in terms of feed conversion and body weight of poultry, regardless of the feeding ration. The body weight of chickens at the age of 17 weeks in both groups was in the range of 1,862.4-1,895.6 g, feed consumption per 1 kg of body weight gain was 3.65-3.76 kg, the livestock viability -96.6-97.3%. The results of the study do not indicate any danger to the metabolism and health of the bird due to the use of genetically modified feed, as no statistically significant differences within the studied parameters were observed. The noted certain small deviations fell within the limits of normal variations of the considered indicators and, thus, had no biological or toxicological value.

show abstract

“…The pre-testing for the safety of GM crops in several areas has indicated no evidence of any adverse reactions ( Kamle et al., 2017 ). Although the negative health consequences of GM crops consumption are reported on rats, analyses of most of the studies about the safety of GM crops, indicated no human health consequences ( Szymczyk et al., 2018 ; Giraldo et al., 2019 ).…”

Section: Perspectives On the Criticisms Of Gm Crops Incorporation Int...mentioning

confidence: 99%

Genetically engineered crops for sustainably enhanced food production systems

Aziz

Brini²,

Rouached³

et al. 2022

Front. Plant Sci.

View full text Add to dashboard Cite

Genetic modification of crops has substantially focused on improving traits for desirable outcomes. It has resulted in the development of crops with enhanced yields, quality, and tolerance to biotic and abiotic stresses. With the advent of introducing favorable traits into crops, biotechnology has created a path for the involvement of genetically modified (GM) crops into sustainable food production systems. Although these plants heralded a new era of crop production, their widespread adoption faces diverse challenges due to concerns about the environment, human health, and moral issues. Mitigating these concerns with scientific investigations is vital. Hence, the purpose of the present review is to discuss the deployment of GM crops and their effects on sustainable food production systems. It provides a comprehensive overview of the cultivation of GM crops and the issues preventing their widespread adoption, with appropriate strategies to overcome them. This review also presents recent tools for genome editing, with a special focus on the CRISPR/Cas9 platform. An outline of the role of crops developed through CRSIPR/Cas9 in achieving sustainable development goals (SDGs) by 2030 is discussed in detail. Some perspectives on the approval of GM crops are also laid out for the new age of sustainability. The advancement in molecular tools through plant genome editing addresses many of the GM crop issues and facilitates their development without incorporating transgenic modifications. It will allow for a higher acceptance rate of GM crops in sustainable agriculture with rapid approval for commercialization. The current genetic modification of crops forecasts to increase productivity and prosperity in sustainable agricultural practices. The right use of GM crops has the potential to offer more benefit than harm, with its ability to alleviate food crises around the world.

show abstract

Results of a 16-week safety assurance study with rats fed genetically modified Bt maize: effect on growth and health parameters

Cited by 8 publications

References 22 publications

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810

Expression profiling of key pathways in rat liver after a one-year feeding trial with transgenic maize MON810

Effect of GM maize on metabolism and performance of chicken

Genetically engineered crops for sustainably enhanced food production systems

Contact Info

Product

Resources

About