Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma

Yamashita, Hiroharu; Seto, Yasuyuki; Sano, Takeshi; Makuuchi, Hiroyasu; Ando, Nobutoshi; Sasako, Mitsuru

doi:10.1007/s10120-016-0663-8

Cited by 184 publications

(164 citation statements)

References 28 publications

(26 reference statements)

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“…1b). Although the report from Yamashita et al [5] and our data showed growing trends of EGJ adenocarcinoma, these were attributed to an increase of the elderly population in Japan. The search in PubMed revealed that there were no reports examining the incidence trend of EGJ adenocarcinoma in other Asian countries, such as Korea or China.…”

Section: Recent Trends Of Egj Adenocarcinoma In Japancontrasting

confidence: 44%

“…They demonstrated that the proportion of Siewert type II increased between 1962 and 2005, but that of Siewert type I remained around 1% over 44 years. Recently, Yamashita et al [5] showed that the number of surgically resected cases of EGJ adenocarcinoma were gradually increased between 2001 and 2010, using a questionnaire-based national retrospective study in Japan. In their article, EGJ adenocarcinoma was defined as tumors with epicenter located within 2 cm proximal or distal to the anatomical EGJ by the Japanese classification of gastric cancer (14th edition, Japanese only).…”

Section: Recent Trends Of Egj Adenocarcinoma In Japanmentioning

confidence: 99%

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Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients

et al. 2018

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Background: The incidence trend of esophagogastric junction (EGJ) adenocarcinoma in Japan has not been sufficiently investigated. Little is known about the microsatellite instability (MSI) status of this tumor. Summary: Previously published studies analyzing the trend of EGJ adenocarcinoma in Japan were reviewed. And a trend of surgically resected cases (Siewert type I-III) utilizing a retrospective multicenter cohort of 379 patients from 4 academic institutions in Japan investigated. Although an increasing trend in the last 2 reports was considered controversial, our cohort demonstrated a growing number of EGJ adenocarcinoma cases between 2006 and 2013. This trend was evident, especially in Siewert type I cases. In the previous 16 studies that performed MSI testing, MSI-high tumors ranged 0–8.3%, though there were no fixed microsatellite markers on EGJ adenocarcinoma. In a recent comprehensive genetic analysis by The Cancer Genome Atlas, MSI testing using the following 7 markers, BAT25, BAT26, BAT40, D2S123, D5S346, D17S250 and TGFR-II showed a favorable correlation with hypermutated tumors. We performed MSI testing using 6 of those markers, except TGFR-II, on 206 cases from one institution, and detected 15 cases (7.3%) with MSI-high. The prevalence of MSI-high was 0% in Siewert type I, 7.6% in type II, and 16.7% in type III. Key message: The number of surgically resected EGJ adenocarcinoma cases gradually increased, and MSI-high was infrequent in Siewert type I-II tumors in our Japanese cohort. Considering MSI-high as a predictive biomarker for emerging immune checkpoint inhibitors, MSI status is becoming more beneficial in EGJ adenocarcinoma.

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Section: Recent Trends Of Egj Adenocarcinoma In Japancontrasting

confidence: 44%

Section: Recent Trends Of Egj Adenocarcinoma In Japanmentioning

confidence: 99%

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients

et al. 2018

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“…Dissection of mediastinal lymph nodes could be indicated and may, in some cases, even be recommended for patients with junctional cancer, given the presence of long‐term survivors among patients with metastases to such lymph nodes 15. Furthermore, patients with para‐aortic lymph node metastases beyond the a2 and b1 regions could still be indicated for surgery pending marked shrinkage of these nodes during chemotherapy which, originally, would have been cause for palliation.…”

Section: Lymph Node Metastasismentioning

confidence: 99%

Surgery with curative intent for stage IV gastric cancer: Is it a reality of illusion?

Kodera

2018

Annals of Gastroent Surgery

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Gastric cancer with metastases outside of the regional lymph nodes is deemed oncologically unresectable. Nevertheless, some metastatic lesions are technically resectable by applying established surgical techniques such as para‐aortic lymphadenectomy and hepatectomy. At the time of compilation of the Japanese gastric cancer treatment guidelines version 4, systematic reviews were conducted to see whether it is feasible to make any recommendation to dissect both the primary and metastatic lesions with intent to cure, possibly as part of multimodality treatment. Long‐term survivors were found among carefully selected groups of patients both in prospective and retrospective studies. In addition, there is a growing list of publications reporting encouraging outcomes of gastrectomy conducted after exceptionally good response to chemotherapy, usually among patients who underwent R0 resection. This type of surgery is often referred to as conversion surgery. It is sometimes difficult to define a clear borderline between curative surgery scheduled after neoadjuvant chemotherapy and the conversion surgery. This review summarizes what we knew after the literature reviews conducted at the time of compiling the Japanese guidelines and in addition reflects some new findings obtained thereafter through clinical trials and retrospective studies. Metastases were divided into three categories based on the major metastatic pathways: lymphatic, hematogenous, and peritoneal. In each of these categories, there were findings that could provide hope for patients with metastatic disease. These findings implied that the surgical technique that we already use could become more useful upon further developments in antineoplastic agents and drug delivery.

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“…Yamashita et al reported clinical records of 2807 EGJ carcinoma patients without preoperative therapy in Japan [20]. There are obvious unbalances in terms of lymph node dissection rate according to histology and the main tumor location.…”

Section: Lymph Node Metastasis Of Eacmentioning

confidence: 99%

Lymph Node Dissection along the Recurrent Laryngeal Nerve in Video-Assisted Thoracoscopic Surgery (VATSE) for Esophageal Squamous Cell Carcinoma

Makino¹,

Yoshida²,

Uchida³

2017

Esophageal Abnormalities

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Esophageal carcinoma is the ninth most common cancer in the world, which is frequently seen in Asia and east Africa. Around 80% of all cases occurred in less-developed regions. Two major histological subtypes of esophageal carcinoma, adenocarcinoma and squamous cell carcinoma, are known to differ greatly in terms of risk factor, epidemiology, male to female ratios, and incidence. Lymph node metastasis is a crucial factor in staging and prognosis is associated with surgical treatment and a major lymphatic chain into the neck. Esophageal adenocarcinoma (EAC) is mainly detected at the lower third of the thoracic esophagus or esophago-gastric-junction (EGJ) and metastasizes mainly to lymph nodes of the lesser sac, celiac regions and lower mediastinal. Esophageal squamous cell carcinoma (ESCC) has a predilection for metastasis to the lymph nodes of the cervical region including recurrent laryngeal nerve (RLN) on both sides. Lymph node dissection is vital yet difficult, left-side lymph node dissection especially requires expertise. There are some reports on lymph node dissection in the prone position by video-assisted thoracoscopic surgery of the esophagus (VATS-E) along the left RLN in Japan and China. We also introduce a stripping method for lymph node dissection in this site.

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Results of a nation-wide retrospective study of lymphadenectomy for esophagogastric junction carcinoma

Cited by 184 publications

References 28 publications

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients

Recent Incidence Trend of Surgically Resected Esophagogastric Junction Adenocarcinoma and Microsatellite Instability Status in Japanese Patients

Surgery with curative intent for stage IV gastric cancer: Is it a reality of illusion?

Lymph Node Dissection along the Recurrent Laryngeal Nerve in Video-Assisted Thoracoscopic Surgery (VATSE) for Esophageal Squamous Cell Carcinoma

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