Results of an explorative clinical evaluation suggest immediate and persistent post-reperfusion metabolic paralysis drives kidney ischemia reperfusion injury

Lindeman, J.; Wijermars, Leonie G.M.; Kostidis, Sarantos; Mayboroda, Oleg A.; Harms, Amy C.; Hankemeier, Thomas; Bierau, Jörgen; Gupta, Karthick Babu Sai Sankar; Giera, Martin; Reinders, Marlies E.J.; Zuiderwijk, Melissa; Dévédec, Sylvia E. Le; Schaapherder, Alexander F.; Bakker, J.

doi:10.1016/j.kint.2020.07.026

Cited by 27 publications

(45 citation statements)

References 42 publications

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“…Based on the observation that all NMP studies of human kidneys so far report accruing lactate perfusate levels (3-5, 12, 13), it could be argued that a physiological metabolic state is not established under the current NMP conditions (15,16). While this phenomenon may reflect use of discarded kidneys, lactate accumulation is also observed during NMP of kidneys that were accepted for transplantation (3).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Finally, a practical overview of the options for monitoring metabolic homeostasis in the context of NMP is provided. Reference data with regard to aspects of the metabolic physiology of the kidney largely rely on human (living donors) and porcine studies that applied arteriovenous blood sampling over the kidney (16,18).…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…Absent lactate release, or even net lactate uptake from the circulation under physiologic conditions (15,16,18) implies that the lactate formed in the deeper medulla is efficiently cleared within the organ (32). Recent studies identified the proximal tubules as the primary site of lactate disposal (15).…”

Section: Carbohydratesmentioning

confidence: 99%

“…An exception is the insulin dependent GLUT4 which controls postprandial glucose disposal (37). Since GLUT4 is also expressed in the kidney (16,38), insulin supplementation during NMP should be considered.…”

Section: Carbohydratesmentioning

confidence: 99%

“…For citrate, it has been speculated that this clearance reflects urinary excretion mechanism as part of a citrate disposal system (40). Yet, tracer studies in mice (15) and persistent citrate clearance by transiently anuric deceased donor grafts in the phase immediately following transplantation imply that citrate is, at least partially, metabolized by the kidney rather than just secreted in the urine (16). Consequently, citrate could be considered a carbon source in the context of renal NMP.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

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Metabolic needs of the kidney graft undergoing normothermic machine perfusion

Arykbaeva

Vries

Doppenberg

et al. 2021

Kidney International

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Section: Carbohydratesmentioning

confidence: 99%

Section: Carbohydratesmentioning

confidence: 99%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

See 3 more Smart Citations

Metabolic needs of the kidney graft undergoing normothermic machine perfusion

Arykbaeva

Vries

Doppenberg

et al. 2021

Kidney International

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Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line

Faucher,

Chadet,

Humeau

et al. 2023

Metabolomics

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Plasmalogens and Octanoylcarnitine Serve as Early Warnings for Central Retinal Artery Occlusion

Wang,

Li,

Feng

et al. 2024

Mol Neurobiol

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Central retinal artery occlusion (CRAO) is a kind of ophthalmic emergency which may cause loss of functional visual acuity. However, the limited treatment options emphasize the significance of early disease prevention. Metabolomics has the potential to be a powerful tool for early identification of individuals at risk of CRAO. The aim of the study was to identify potential biomarkers for CRAO through a comprehensive analysis. We employed metabolomics analysis to compare venous blood samples from CRAO patients with cataract patients for the venous difference, as well as arterial and venous blood from CRAO patients for the arteriovenous difference. The analysis of metabolites showed that PC(P-18:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z)), PC(P-18:0/20:4(5Z,8Z,11Z,14Z)) and octanoylcarnitine were strongly correlated with CRAO. We also used univariate logistic regression, random forest (RF), and support vector machine (SVM) to screen clinical parameters of patients and found that HDL-C and ApoA1 showed significant predictive efficacy in CRAO patients. We compared the predictive performance of the clinical parameter model with combined model. The prediction efficiency of the combined model was significantly better with area under the receiver operating characteristic curve (AUROC) of 0.815. Decision curve analysis (DCA) also exhibited a notably higher net benefit rate. These results underscored the potency of these three substances as robust predictors of CRAO occurrence.

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Results of an explorative clinical evaluation suggest immediate and persistent post-reperfusion metabolic paralysis drives kidney ischemia reperfusion injury

Cited by 27 publications

References 42 publications

Metabolic needs of the kidney graft undergoing normothermic machine perfusion

Metabolic needs of the kidney graft undergoing normothermic machine perfusion

Impact of hypoxia and reoxygenation on the extra/intracellular metabolome and on transporter expression in a human kidney proximal tubular cell line

Plasmalogens and Octanoylcarnitine Serve as Early Warnings for Central Retinal Artery Occlusion

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