Results of deformity correction in children with X-linked hereditary hypophosphatemic rickets by external fixation or combined technique

Попков, А. В.; Аранович, А. М.; Popkov, Dmitry

doi:10.1007/s00264-015-2814-7

Cited by 31 publications

(27 citation statements)

References 34 publications

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“…We have hypothesized that intramedullary osteosynthesis could be realized with HA-coated wires available on our market and started to use them instead of regular nails in clinical practice for reinforcement of bone fragments stability in diaphyseal fracture repair, bone lengthening and deformity correction in combination with the Ilizarov external fixation [6–9]. We observed that bone formation and repair went on faster with their use [7].…”

Section: Discussionmentioning

confidence: 99%

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Bioactivity and osteointegration of hydroxyapatite-coated stainless steel and titanium wires used for intramedullary osteosynthesis

Попков¹,

Горбач²,

Кононович³

et al. 2017

Strategies in Trauma and Limb Reconstruction

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A lot of research was conducted on the use of various biomaterials in orthopedic surgery. Our study investigated the effects of nanostructured calcium–phosphate coating on metallic implants introduced into the bone marrow canal. Stainless steel or titanium 2-mm wires (groups 1 and 2, respectively), and hydroxyapatite-coated stainless steel or titanium wires of the same diameter (groups 3 and 4, respectively) were introduced into the tibial bone marrow canal of 20 dogs (each group = 5 dogs). Hydroxyapatite coating was deposited on the wires with the method of microarc oxidation. Light microscopy to study histological diaphyseal transverse sections, scanning electron microscopy to study the bone marrow area around the implant and an X-ray electron probe analyzer to study the content of calcium and phosphorus were used to investigate bioactivity and osteointegration after a four weeks period. Osteointegration was also assessed by measuring wires’ pull-off strength with a sensor dynamometer. Bone formation was observed round the wires in the bone marrow canal in all the groups. Its intensity depended upon the features of wire surfaces and implant materials. Maximum percentage volume of trabecular bone was present in the bone marrow canals of group 4 dogs that corresponded to a mean of 27.1 ± 0.14%, while it was only 6.7% in group 1. The coating in groups 3 and 4 provided better bioactivity and osteointegration. Hydroxyapatite-coated titanium wires showed the highest degree of bone formation around them and greater pull-off strength. Nanostructured hydroxyapatite coating of metallic wires induces an expressed bone formation and provides osteointegration. Hydroxyapatite-coated wires could be used along with external fixation for bone repair enhancement in diaphyseal fractures, management of osteogenesis imperfecta and correction of bone deformities in phosphate diabetes.

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Section: Discussionmentioning

confidence: 99%

“…Recently, flexible intramedullary nailing with thin wires, HA coated or uncoated, has been advocated for management of diaphyseal fractures, lengthening and deformity correction [6–9]. It was observed that the use of such wires stimulated bone reparation and reduced the total period of treatment in clinical settings.…”

Section: Introductionmentioning

confidence: 99%

Bioactivity and osteointegration of hydroxyapatite-coated stainless steel and titanium wires used for intramedullary osteosynthesis

Попков¹,

Горбач²,

Кононович³

et al. 2017

Strategies in Trauma and Limb Reconstruction

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“…Надо отметить, что в нашей серии с обычными ти-тановыми стержнями было отмечено 8 случаев такого осложнения [19]. С другой стороны, стабилизирующий эффект биоактивного покрытия мы наблюдали и при коррекции деформаций у детей с фосфат-диабетом [16].…”

Section: вопросы детской ортопедииunclassified

“…Было доказано, что высоко-дробное круглосуточное удлинение благоприятно влияет как на репаративный остеогенез, так и на функциональ-ную реабилитацию после лечения [13][14][15]. Другим спосо-бом, стимулирующим костное сращение при удлинении конечностей, является интрамедуллярное эластичное армирование, в том числе, с биоактивным покрытием [16][17][18][19][20]. Экспериментальные исследования показали, что интрамедуллярное введение эластичных стержней не нарушает целостности питательной артерии и, таким образом, не противоречит принципам метода Илизарова [14,21].…”

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“…Экспериментальные исследования показали, что интрамедуллярное введение эластичных стержней не нарушает целостности питательной артерии и, таким образом, не противоречит принципам метода Илизарова [14,21]. Наконец, биоактивное кальций-фосфатное или гидроксиапатитное покрытие способно стимулировать костное сращение, препятствует миграции имплантов и уже находит свое применение при лечении деформаций у детей с метаболическими остеопатиями [16,17].…”

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