Results of duodenopancreatectomy for solitary pancreatic metastasis from renal cell carcinoma

Abstract

The pancreas is an uncommon site of metastasis from renal cell carcinoma. We present five patients with solitary pancreatic metastasis from renal cell carcinoma located in the head of the pancreas, treated by duodenopancreatectomy. There were no perioperative deaths. Mean survival was 48 months; three patients were alive at the end of the study (at 27, 46, and 88 months, respectively) and two patients died, at 13 and 70 months. The 3- and 5-year survival rates of our patients together with 22 previously reported patients were 86% and 68%, respectively. We advocate aggressive surgical treatment when the metastatic disease is limited to the pancreas.

Metastatic Disease to the Pancreas and Spleen

“…35,36 It is likely that surgical intervention for solitary pancreatic metastasis from RCC provides a survival benefit, although such benefit may be due to both the extent of disease and the surgical resection. 5,20,33,37,38 Lung Cancer Lung cancer is the most common cause of cancerrelated death in the United States.13 Lung cancer is typically classified as either small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma), based on pathologic parameters.…”

Solitary Pancreatic Metastasis from Renal Cell Carcinoma Concomitant with Early Gastric Cancer 17 Years After Nephrectomy: Report of a Case

“…6 Tuech et al also reported 68% 5-year survival rate after surgical resection of pancreatic metastasis, being a particularly favorable characteristic of renal cell carcinoma. 21 Other favorable factors associated with metastasis resection have been reported, including: a long interval between primary tumor resection and the development of a metastatic focus (often over 10 years); evidence of a solitary or isolated lesion in the pancreas (usually identified radiographically); spontaneous regression of metastatic lesions; demonstration of extensive necrosis in the resected specimen; and show evolution or growth of the tumor and a lack of clinical symptoms. 6 According to these findings, we consider that our patient's prognosis is relatively favorable.…”

CyberKnife Robotic Radiosurgery of Three Pancreatic Metastases of Renal Cell Cancer in One Treatment Session

“…Multiple metastatic lesions have a worse prognosis than solitary ones. The best treatment is described to be a R0 resection of the tumor, which is curative in most cases of solitary tumors [9][10][11]. Katsurakis, et al stated that the only possible curative treatment is R0 resection [12].…”

“…Atypical resection of pancreatic metastasis from renal cell carcinoma, such as duodenum-preserving pancreatic head resection, middle pancreatectomy, and enucleation of the tumor, has been adopted by some authors. Atypical resection has been adopted based on the fact that these lesions are well-encapsulated [1][2][3][8][9][10][11]. Five-year survival ranges from 29% to 81%.…”