Results of endoscopic resection followed by radiotherapy for primarily diagnosed adenocarcinomas of the paranasal sinuses

Bogaerts, Sofie; Poorten, Vincent Vander; Nuyts, Sandra; Bogaert, Walter Van den; Jorissen, Mark

doi:10.1002/hed.20771

Cited by 57 publications

(81 citation statements)

References 29 publications

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“…For instance, all IMRT-treated patients received a preoperative MRI, which was also used for GTV delineation. Second, surgical techniques have improved as well, with increasing experience in the use of endoscopic sinus surgery at our department (7). Nonetheless, the two patients groups were largely similar, since our institutional guidelines remained constant throughout.…”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Intensity-Modulated Radiotherapy for Sinonasal Cancer: Improved Outcome Compared to Conventional Radiotherapy

Dirix

Vanstraelen

Jorissen³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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135

116

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Section: Discussionmentioning

confidence: 96%

“…Recently, endoscopic sinus surgery has been used more often, since it results in comparable tumor control rates but with lower morbidity (7). Nonetheless, the limitations of surgery alone are obvious given the frequent presentation of advanced disease.…”

Section: Introductionmentioning

confidence: 98%

Intensity-Modulated Radiotherapy for Sinonasal Cancer: Improved Outcome Compared to Conventional Radiotherapy

Dirix

Vanstraelen

Jorissen³

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

Self Cite

135

116

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“…Ever since the advent of nasal endoscopic surgeries [13] and its exploration in the field of oncological surgeries, much has been debated and currently consensus is to use it in early staged diseases and in advanced stage for debulking [14]. Issues of piecemeal resection-tumour spillage and adequacy of margin, during endoscopic surgeries have been discussed by Bogaerts et al [15] and endoscopic resection has been concluded to be safe in terms of disease clearance and overall survival with reduced morbidity, in selected cases like carcinomas of ethmoids without intradural extension, similar results have been replicated by Arnold et al [16]. In our series, majority of stage IV patients were treated by radical surgery with postoperative radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Malignancies: Long Term Follow Up After Surgical Management—An Analysis of Outcomes

Devaraja

Sikka

Kumar

et al. 2014

Indian J Otolaryngol Head Neck Surg

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Sinonasal malignancies are rare and survival analysis in affected patients is arduous and perplexing due to various factors. In this review article, attempt has been made to overcome some of those factors while analysing survival outcomes. Aims and objectives: The aim of this study was to share the experience of a tertiary care centre in the surgical management of sinonasal malignancies over 12 years. Materials and Methods: This study is a retrospective chart review, and in this study, hospital records of 58 patients with biopsy proven sinonasal malignancies were studied. Only the patients undergoing primary or salvage surgery at our institution from May-2000 to April-2012 with a minimum follow up of 2 years were included. Statistical analyses such as means, proportions, KaplanMeier analysis and Cox's regression model were done. Results: Majority of the patients were males (n = 43) belonging to fourth and fifth decades. Squamous cell carcinoma was the most common (n = 17) histopathological type, followed by adenoid cystic carcinoma (n = 14). Majority presented with stage IV disease (n = 42). 17 patients were operated for recurrent disease. Over all 5 year survival was 72 % and disease free survival was 44 %. Separate analysis for epithelial and matched nonepithelial group showed poorer prognosis with epithelial group (p = 0.0120). Multivariate analysis showed histopathological type (epithelial) and presence of pathological risk factors (positive margins and/or perineural invasion) affecting survival. Conclusions: Advanced stage presentation is the norm for sinonasal malignancies. This study noted a 5 year overall survival of 72 % and disease free survival of 44 %. Epithelial histopathology carries poorer prognosis then other counterparts and incomplete removal is shown to add to poor prognosis independently.

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“…The outcome of endoscopic surgery followed by radiotherapy in adenocarcinoma has been reported by Bogaerts et al [34] in a series of 44 patients, including one T1, 26 T2, 5 T3, 9 T4a for sphenoid sinus involvement, and 3 T4b for limited dural involvement. Median followup, as well as follow-up of patients alive at the end of follow-up, was 36 months.…”

Section: Outcomementioning

confidence: 88%

“…The major criticisms on the available data concern the short followup time, the limited number of patients, and the fact that most series grouped together different histologies. In fact, only a few reports have analyzed data on the outcome in specific histotypes such as adenocarcinoma [34,35] or olfactory neuroblastoma [36][37][38], while only two papers collected large cohorts of patients [22•, 39•]. Furthermore, comparison between the results obtained with endoscopic surgery and craniofacial resection, which has been considered for many decades the gold standard in management of malignant tumors abuting the anterior skull base, is hindered by the heterogeneous composition of patient series in terms of histology, stage, and follow-up time.…”

Section: Outcomementioning

confidence: 98%

Endoscopic Resection of Sinonasal Malignancies

2011

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Malignant tumors of the sinonasal tract are rare, accounting for only 1% of all malignancies. Although they are associated with substantial histological heterogeneity, surgery plays a key role in their management. This review addresses the evolution of current treatments in view of the introduction of endoscopic resection techniques. The absence of facial incisions and osteotomies, decreased hospitalization time, better control of bleeding, improved visualization of tumor borders, and reduced morbidity and mortality rate are the major advantages of endoscopic techniques in comparison to traditional external approaches. The major criticisms focus on oncologic results in view of the short/intermediate follow-up of large series, which have commonly grouped together several histologies that may be associated with different prognoses. Since prospective studies contrasting the results of endoscopic and craniofacial resections are difficult to carry out given the rarity of the disease together with ethical issues, the creation of a large database would favor the analysis of several variables related to the patient, tumor, and treatment on survival performed on a large number of patients.

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Results of endoscopic resection followed by radiotherapy for primarily diagnosed adenocarcinomas of the paranasal sinuses

Abstract: Endoscopic sinus surgery followed by radiotherapy for primary adenocarcinoma of the paranasal sinuses gives oncological results comparable to those of standard external approaches.

Cited by 57 publications

References 29 publications

Intensity-Modulated Radiotherapy for Sinonasal Cancer: Improved Outcome Compared to Conventional Radiotherapy

Intensity-Modulated Radiotherapy for Sinonasal Cancer: Improved Outcome Compared to Conventional Radiotherapy

Sinonasal Malignancies: Long Term Follow Up After Surgical Management—An Analysis of Outcomes

Endoscopic Resection of Sinonasal Malignancies

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