Results of ofloxacin therapy in andrologic patients suffering from therapy-requiring asymptomatic infections

Abstract

In 1990, microbiological ejaculate analyses were carried out on a routine basis on 125 andrological patients, in addition to the determination of the concentration, motility and morphology of the spermatozoa. Fourteen patients (1 1.2%) with therapy-requiring asymptomatic infections (TAI) > lo4 CFU (colony-forming units) ml-' were effectively treated with Ofloxacin (TarividR) at 2 x 200 mg d-I for a period of 20 d. Concentration, motility and morphology of the spermatozoa were determined before the Ofloxacin treatment and controlled 1, 3, and 6 months later and correlated to the values obtained before the treatment. Over the entire period of observation, the morphology did not change significantly, whilst initially 1 month after the treatment the concentration and the motility decreased significantly (P< 0.05). Three months later they again reached the starting values. After 6 months, a significant improvement occurred with regard to the motility, as compared to the starting values (P< 0.01), whilst the concentration remained at the level of the starting values. By this, Ofloxacin has been proved to be an effective medication for the treatment of TAI. In the end, it still remains an open question whether the improvement in sperm motility is primarily related to the Ofloxacin therapy.

Morphological and morphometric evaluation of silver barb, Barbodes gonionotus (Bleeker, 1849) sperm supplemented with antibiotics

“…Degenerative changes in sperm supplemented with 0.5% PG in the present study were possibly due to an inhibition of phosphatase activity, decrease in membrane integrity of sperm, increase in peroxide radical generation, and depletion of antioxidant enzymes levels in semen following gentamicin incorporation as demonstrated in vitro by Andreessen et al. () and Narayana (). However, morphological damage of silver barb sperm in this study was possibly due to improper fixation prior to electron microscopy.…”

Testicular Morphological Changes Produced by Fluoroquinolones in Adult Male Albino Rats

“…20 Anderson et al (2012) showed that Ofloxacin at a dose of 72 mg/kg per day had almost the highest potential in terms of impairment of the rat testicular function. 24 Other studies also added that fluoroquinolones have toxic effects on testicular functions of different animals .21,25-28…”

Prostatic peptides for the correction of pathospermia in patients with chronic bacterial prostatitis

“…Лечение ХП, сопровождающегося патоспермией, является еще более сложной задачей, поскольку длительные курсы антибактериальной терапии и использование ряда других средств патогенетической терапии могут вести к еще большему ухудшению показателей оплодотворяющей способности спермы. В современной литературе доступен ряд экспериментальных и клинических исследований, в которых продемонстрировано негативное влияние антибактериальных препаратов на сперматогенез [16,17]. Именно поэтому для лечения подобной категории пациентов необходимо использование лекарственных средств, позволяющих купировать воспалительный процесс в предстательной железе, улучшить физикохимические и биохимические характеристики секрета простаты и в то же время оказывающих позитивное влияние на сперматогенез.…”