Results of salvage radiotherapy after inadequate surgery in invasive cervical carcinoma patients: A retrospective analysis

Saibishkumar, Elantholi P.; Patel, Firuza D.; Ghoshal, Sushmita; Kumar, Vinay; Karunanidhi, Gunaseelan; Sharma, Suresh C.

doi:10.1016/j.ijrobp.2005.04.002

Cited by 15 publications

(11 citation statements)

References 21 publications

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“…Invasive cervical cancer may be found during pathologic evaluation of the specimen of a simple hysterectomy for an apparent benign condition. Inadvertent simple hysterectomy is considered inadequate Although PORT for patients following inadvertent simple hysterectomy has been shown to be beneficial, 116,117 the outcome for such patients even after PORT remains very poor with 5-year recurrencefree survival of 49%, 33 and therefore CCRT is generally added. In a study from India, Sharma et al 116…”

Section: Radiation Therapy After Inadvertent Incomplete Surgerymentioning

confidence: 99%

Cancer of the cervix uteri

Bhatla

Aoki

Sharma

et al. 2018

Intl J Gynecology & Obste

950

799

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Since the publication of the last FIGO Cancer Report there have been giant strides in the global effort to reduce the burden of cervical cancer, with WHO announcing a call for elimination. In over 80 countries, including LMICs, HPV vaccination is now included in the national program. Screening has also seen major advances with implementation of HPV testing on a larger scale. However, these interventions will take a few years to show their impact. Meanwhile, over half a million new cases are added each year. Recent developments in imaging and increased use of minimally invasive surgery have changed the paradigm for management of these cases. The FIGO Gynecologic Oncology Committee has revised the staging system based on these advances. This chapter discusses the management of cervical cancer based on the stage of disease, including attention to palliation and quality of life issues.

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Section: Radiation Therapy After Inadvertent Incomplete Surgerymentioning

confidence: 99%

Cancer of the cervix uteri

Bhatla

Aoki

Sharma

et al. 2018

Intl J Gynecology & Obste

950

799

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“…There is evidence of adequate local control with radical radiotherapy of residual disease after inadequate hysterectomy for cervical cancer. 8 - 10 …”

Section: Resultsmentioning

confidence: 99%

Chemoradiation and the Role of Adjuvant Chemotherapy in Lymph Nodal–Metastatic Cervical Cancer

Nasir

Valimohammad

Abbası

et al. 2018

JGO

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PurposeTo report the long-term outcome in lymph nodal–metastatic cervical squamous cell cancer after chemoradiation followed by adjuvant chemotherapy.Patients and MethodsBetween 2010 and 2013, five patients were diagnosed with advanced cervical cancer with clinically involved para-aortic lymph nodes (ie, International Federation of Gynecology and Obstetrics stage IVB). These patients were treated with concurrent chemoradiation therapy followed by adjuvant chemotherapy. Concurrent chemoradiation consisted of cisplatin given once per week concomitantly with extended-field radiation therapy followed by high-dose-rate brachytherapy. Adjuvant chemotherapy comprised four courses of carboplatin and paclitaxel given every three weeks. The primary outcomes were local and distant failures.ResultsNone of the patients had local recurrence or distal failure after a minimum follow-up time of 3 years.ConclusionAdjuvant chemotherapy after chemoradiation has a probable role in the management of lymph nodal–metastatic cervical cancer.

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“…12 Results from recent studies in patients undergoing surgery for head and neck cancer, cervical cancer, uterine cancer, and non-small-cell lung cancer supported this conclusion by demonstrating that anemia is an independent prognostic factor for decreased locoregional control, disease-free survival, and overall survival. [13][14][15][16][17][18] Reviews of the available evidence have demonstrated a strong relationship between anemia and decreased quality of life in patients with cancer, 19,20 but clinical studies of this association typically have focused on chemotherapy-associated anemia, not anemia in patients with cancer who underwent surgery. Additional study would be needed to determine whether the association between anemia and postoperative morbidity, mortality, and quality of life exists in patients who are undergoing cancer-related surgery.…”

Section: Consequences Of Anemiamentioning

confidence: 99%

Anemia and Transfusions in Patients Undergoing Surgery for Cancer

2007

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Preoperative, operative, and postoperative factors may all contribute to high rates of anemia in patients undergoing surgery for cancer. Allogeneic blood transfusion is associated with both infectious risks and noninfectious risks such as human errors, hemolytic reactions, transfusion-related acute lung injury, transfusion-associated graft-versus-host disease, and transfusion-related immune modulation. Blood transfusion may also be associated with increased risk of cancer recurrence. Blood-conservation measures such as preoperative autologous donation, acute normovolemic hemodilution, perioperative blood salvage, recombinant human erythropoietin (epoetin alfa), electrosurgical dissection, and minimally invasive surgical procedures may reduce the need for allogeneic blood transfusion in elective surgery. This review summarizes published evidence of the consequences of anemia and blood transfusion, the effects of blood storage, the infectious and noninfectious risks of blood transfusion, and the role of blood-conservation strategies for cancer patients who undergo surgery. The optimal blood-management strategy remains to be defined by additional clinical studies. Until that evidence becomes available, the clinical utility of blood conservation should be assessed for each patient individually as a component of preoperative planning in surgical oncology.

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Results of salvage radiotherapy after inadequate surgery in invasive cervical carcinoma patients: A retrospective analysis

Cited by 15 publications

References 21 publications

Cancer of the cervix uteri

Cancer of the cervix uteri

Chemoradiation and the Role of Adjuvant Chemotherapy in Lymph Nodal–Metastatic Cervical Cancer

Anemia and Transfusions in Patients Undergoing Surgery for Cancer

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