Results of surgery plus postoperative radiotherapy for patients with malignant parotid tumor

Matsuda, Shogo; Iguchi, Hiroyoshi; Tada, Takuhito; Hosono, Mitsuharu; Osawa, Motoki; Kuwae, Yuuko; Morimoto, Hideyuki; Okazaki, Eiichiro; Amano, Kosuke; Miki, Yukari; Tsutsumi, S.; Shimatani, Yasuhiko; Miki, Yukio

doi:10.1007/s11604-015-0450-1

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…Our favorable survival outcomes suggest that SMG malignancies are more similar in behavior to parotid cancer than expected. Some recent experiences in the treatment of parotid gland cancer, in fact, report a 5‐year OS ranging between 60% and 82% . Some speculations may be advanced to explain our encouraging results: first of all, meticulous diagnostic workup is essential to properly define local extension of the tumor and to obtain clues about its biologic aggressiveness.…”

Section: Discussionmentioning

confidence: 87%

“…Some recent experiences in the treatment of parotid gland cancer, in fact, report a 5year OS ranging between 60% and 82%. [26][27][28][29][30] Some speculations may be advanced to explain our encouraging results: first of all, meticulous diagnostic workup is essential to properly define local extension of the tumor and to obtain clues about its biologic aggressiveness. Second, the surgical technique by itself, with proper use of frozen sections and meticulous management of the neck, reduced the number of patients with positive margins and/or occult nodal disease left in place.…”

Section: Discussionmentioning

confidence: 99%

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Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

et al. 2018

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

et al. 2018

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“…18 summarized 565 patients with salivary gland cancer from national register system and reported a 10-year regional control rate of 87%, Matsuda et al . 19 depicted the 5-year locoregional control rate was 89% in patients undergoing surgery plus postoperative radiotherapy. Additionally, as high as 50% of the recurrent neck disease usually could not be salvaged by surgery in squamous cell carcinoma of the head and neck 13 , but it was noted that all the recurrent patients were successfully treated by radical neck dissection partial owing to the reliability of SLNB in neck management in current study.…”

Section: Discussionmentioning

confidence: 94%

Sentinel lymph node biopsy in cN0 neck management of parotid cancer

Pan

Niu

et al. 2019

Sci Rep

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Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed with cN0 parotid cancer by preoperative fine needle puncture were prospectively enrolled. The neck status was evaluated by SLNB. If node metastasis was proved by SLNB, a neck dissection of level I–V a was performed, or a wait-and-see policy was conducted for the patient. All related information was extracted and analyzed. Positive SLNB result occurred in 33 (16.7%) patients, and level II metastasis was noted in 100% of the patients. Isolated level III metastasis was noted in 3 (9.1%) patients. During our follow-up with mean time of 49.5 months, 20 patients developed regional recurrence, in which 6 patients had neck dissection as part of their initial management. All the recurrent neck disease was successfully salvaged. Therefore, SLNB was a reliable procedure for neck management in parotid cancer.

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“…Conventional radiation therapy was administered as follows (23)(24)(25): The anterior boundary of the parotid region was defined as the anterior edge of the masseter muscle, the posterior boundary was defined as the posterior edge of the mastoid process, the superior boundary was defined as the upper edge of the zygomatic arch and the inferior boundary was defined at the level 1.0 cm beneath the mandible. Neck lymphatic drainage area radiation was complementarily performed in patients confirmed with poorly differentiated tumors, late-stage tumors or neck lymph node metastases as previously described (26).…”

Section: Radiation Therapy All Patients Who Underwent Reoperation Rementioning

confidence: 99%

Reoperation following the use of non‑standardized procedures for malignant parotid tumors

et al. 2017

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Abstract. Non-standardized or conservative procedures are employed when parotid tumors involving the facial nerve or parotid carcinoma are misdiagnosed as benign parotid tumors prior to or during surgery. Remedial measures are usually required when the pathological diagnosis of a malignant parotid tumor is confirmed following surgery. The aim of the present study was to systematically evaluate reoperation subsequent to treatment with non-standardized procedures for malignant parotid tumors, and to explore the preoperative diagnoses, the primary procedure selection and the necessity of reoperation following non-standardized procedures in malignant parotid tumors. A total of 30 patients who met the inclusion criteria, were diagnosed with a malignant parotid tumor and underwent reoperation following the use of a non-standardized procedure were included in the present study. Surgical conditions and clinical data were analyzed. Among the patients with a malignant parotid tumor who underwent reoperation subsequent to a non-standardized procedure, the incidence of residual tumor, as confirmed by pathological examination, was 63.3% (19/30). The intact facial nerve preservation rate was 83.3% (25/30), the facial nerve branch resection rate was 6.7% (2/30), the facial partial nerve resection rate was 6.7% (2/30) and the facial nerve resection rate was 3.3% (1/30). In total, 3 patients underwent facial nerve reconstruction, 3 patients underwent a local flap repair of skin defects in the parotid region and 3 patients underwent pectoralis major muscle flap repair. The current findings indicate that the qualitative diagnosis of malignant parotid tumors prior to surgery is difficult, there is a high incidence of residual tumor following non-standardized procedures, and that reoperation in a timely manner is required in such cases.

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Results of surgery plus postoperative radiotherapy for patients with malignant parotid tumor

Abstract: Favorable locoregional control was achieved for patients with malignant parotid tumors who underwent surgery plus postoperative radiotherapy. Patients with high-grade tumors frequently experienced distant metastases and prognosis was poor.

Cited by 10 publications

References 21 publications

Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

Long‐term outcomes and prognosis in submandibular gland malignant tumors: A multicenter study

Sentinel lymph node biopsy in cN0 neck management of parotid cancer

Reoperation following the use of non‑standardized procedures for malignant parotid tumors

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