Results of Systematic Nodal Dissection in Typical and Atypical Carcinoid Tumors of the Lung

Wurtz, Alain; Benhamed, Lotfi; Conti, Massimo; Bouchindhomme, B.; Porte, Henri

doi:10.1097/jto.0b013e3181951aa6

Cited by 38 publications

(22 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mineo 2005 emphasized the relevance of micrometastasis detection by immunohistochemical techniques: from 17 to 28% increase in TC group and from 50 to 88% increase in AC group [14]. Literature shows a similar percentage of N2 patients in TC group (0-5%) like in our study (2.1%) [2,5,8,9,15]. In AC group, the higher percentage of N2 patients (11-25%) was confirmed by our study (19%).…”

Section: Discussionsupporting

confidence: 85%

Long-term outcomes and prognostic factors of patients with pulmonary carcinoid tumors

Stolz¹,

Harustiak²,

J³

et al. 2015

neo

View full text Add to dashboard Cite

The aim of the study was to evaluate type of surgery, long-term survival and factors influencing outcome of pulmonary carcinoid tumors. We reviewed our database of 137 patients surgically treated for typical or atypical carcinoid tumors at our department between 1998 and 2013. There were 95 (69%) patients with typical carcinoid (87 N0, 6 N1, 2 N2) and 42 (31%) with atypical carcinoid (26 N0, 8 N1, 8 N2). Patients with atypical carcinoid were older than those with typical carcinoid (median age of 57±8.1 and 50.5±15.8 years, respectively, p<0.00001). The resection performed consisted of 6 (4.4%) pneumonectomies, 110 (80.1%) lobectomies and bilobectomies, 15 (11%) sleeve lobectomies, 2 (1.5%) resections of main bronchus and 4 (3%) wedge resections. Overall 5- and 10-year survival rates for different tumors were as follows: typical carcinoid: 97.2% and 89.9%, respectively; atypical carcinoid 71.1% and 62.2%, respectively. Statistical analyses indicated that histology (typical carcinoid, p<0.00001), age (less than 45 years, p=0.004) and nodal status (N0, p=0.0002) were significant prognostic factors for better prognosis. Histological sub-type and nodal involvement appear as the most important factors influencing the prognosis. Systemic lymphadenectomy is recommended and should always be performed.

show abstract

Section: Discussionsupporting

confidence: 85%

Long-term outcomes and prognostic factors of patients with pulmonary carcinoid tumors

Stolz¹,

Harustiak²,

J³

et al. 2015

neo

View full text Add to dashboard Cite

show abstract

“…Controversies of radical lymph node dissection for LGMTs have remained unsolved [10,21,22]. Although these tumors are regarded as "low-grade malignant" according to their extremely indolent growth and slow progression, presently available data tends to hold an active attitude on lymph dissection over being conservative [22,23].…”

Section: Discussionmentioning

confidence: 99%

Radical mediastinal nodal removal improves disease-free survival for pulmonary low-grade malignant tumors

Zheng

Xie

et al. 2012

Lung Cancer

View full text Add to dashboard Cite

“…At present, the opinions of authors as to whether intraoperative lymph node dissection is worthwhile are inconsistent . Many authors believe that lymph node dissection for lung carcinoid tumors, especially for TC, is not useful for prolonging the mean survival of patients.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung

et al. 2016

View full text Add to dashboard Cite

BackgroundLung carcinoid tumors are rare, low‐grade, malignant neoplasms with some unclear features. The aim of this study was to analyze clinicopathological features and long‐term survival in patients with primary lung carcinoid tumors.MethodsPatients who underwent surgery in our clinic and were diagnosed with carcinoid tumors, between August 1997 and July 2012, were included in the study. Patient characteristics and clinicopathological factors were retrospectively evaluated.ResultsBronchial carcinoids comprised only 1.0% of lung cancer cases treated by resection. They are classified into two distinct categories: typical carcinoid (TC) and atypical carcinoid (AC) tumors. AC tumors occurred more frequently in younger patients and in smokers, and had a poorer prognosis than TC tumors. Overall three and five‐year survival rates for TC and AC were 92.6% and 81.1%, respectively. Univariate analysis showed that tumor size (P = 0.012) and histological type (P = 0.013) are prognostic factors. Multivariate analysis revealed that only tumor size (P = 0.044) was an independent prognostic factor.ConclusionsThe prognosis for bronchial carcinoid tumors was better than other types of lung cancer and TC was significantly better than AC. Radical lymph node dissection was the best treatment, with complete removal of the tumor. Tumor size was an independent prognostic factor for bronchial carcinoid tumors.

show abstract

Results of Systematic Nodal Dissection in Typical and Atypical Carcinoid Tumors of the Lung

Abstract: Systematic nodal dissection showed a high frequency of unpredictable lymphatic spread, mainly in the TC group. This procedure is mandatory to treat carcinoids in a curative intent.

Cited by 38 publications

References 40 publications

Long-term outcomes and prognostic factors of patients with pulmonary carcinoid tumors

Long-term outcomes and prognostic factors of patients with pulmonary carcinoid tumors

Radical mediastinal nodal removal improves disease-free survival for pulmonary low-grade malignant tumors

Clinicopathological characteristics and prognosis of resected cases of carcinoid tumors of the lung

Contact Info

Product

Resources

About