Results of Treatment with Tamoxifen in Oligozoospermie Men

Danner, Ch.; Frick, J.; Maier, F

doi:10.1111/j.1439-0272.1983.tb00221.x

Cited by 15 publications

(10 citation statements)

References 7 publications

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“…Danner et al -1983); Bartsch u. Schreiber (1981) sowie Jecht e t al. Danner et al -1983); Bartsch u. Schreiber (1981) sowie Jecht e t al.…”

Section: Ergebnisse Und Diskussionunclassified

“…Comhaire (1978), Bartsch u. Schreiber (1981) sowie Traub u. Thompson (198 1) hatten bereits eine Besserung spermatologischer Befunde bei hypergonadotropen Patienten beobachtet, Danner et al (1983) sowie Lunglmayr et al (1984) dagegen nicht. Comhaire (1978), Bartsch u. Schreiber (1981) sowie Traub u. Thompson (198 1) hatten bereits eine Besserung spermatologischer Befunde bei hypergonadotropen Patienten beobachtet, Danner et al (1983) sowie Lunglmayr et al (1984) dagegen nicht.…”

Section: Z U M P R O B L E M D E R P a T I E N T E N A U S W A H Lunclassified

“…Auch der GnRH-Test hilft nicht weiter, wie bereits Bartsch u. Schreiber (198 l), Buvat et al (1984), Danner et al (1983) u.a. 4) steigt unter der Ta-Therapie in allen Gruppen signifikant an, die Gruppen unterscheiden sich jedoch, bezogen auf das Testosteron, untereinander nicht.…”

Section: Z U M P R O B L E M D E R P a T I E N T E N A U S W A H Lunclassified

“…

Zusammenfassung: Wahrend einer Smonatigen Tamoxifentherapie (2 x 10 bzw. 1982Danner et al -1983;Dony et al -1985; Jecht et al -1984;Lunglmayr et al -1984; Schill u. Landthaler -1981;Torok -1985; Traub u. Thompson -1981), andere haben mit 10 mg (Butt et al -1978;Willis et al -1977) oder 30 mg/die (Bartsch u. Schreiber -1981) behandelt. Der Prolaktinspiegel f a t ab.

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Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde

et al. 2009

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Zusammenfassung: Wahrend einer Smonatigen Tamoxifentherapie (2 x 10 bzw. 2 x 20 mg/die) kommt es zu einem signifikanten Anstieg von Testosteron, LH, FSH, Ostradiol, freiem Testosteron und SHBG. Der Prolaktinspiegel f a t ab. Im Ejakulat sinken innerhalb des Normwertes der pH-Wert und die Fruktose. Die Spermatozoendichte steigt signifkant an; dabei bleibt unsicher, ob mit 2 x 20 mg/die bessere Ergebnisse erzielt werden.Mit unseren bisherigen Untersuchungsmethoden war eine Auswahl der Patienten, die auf die Behandlung gut ansprechen, nicht moglich. Tamoxifen scheint bei normo-, aber auch bei hypo-und hypergonadotropen Patienten wirksam zu sein. Therapeutic Results with Tamoxifen in Oligozoospermia I I. Hormonal Analysis and Semen ParametersSummary: During a five months lasting treatment with tamoxifen (2 x 10 resp. 2 x 20 mg daily) a significant increase of testosterone, LH, FSH, estradiol, free testosterone and SHBG was found. The prolactin levels diminished. In semen analysis the values of pH and fructose decreased within the normal range. The sperm density increased significantly, but we could not ascertain whether a dosage of 2 x 20 mg/die will provide better therapeutic results. Furthermore the hormonal and seminal investigations described in this paper did not allow to predict those patients who would be good responders on tamoxifen therapy. Tamoxifen seems to be effective in normo-, but also in hypo-and hypergonadotropic patients.Die bisher bei der Behandlung der Oligozoospermie verordnete Tamoxifen (Ta)-Tagesdosis betrug meistens 20 mg (Buvat et al. -1983;Comhaire -1976 Comhaire - u. 1982Danner et al. -1983;Dony et al. -1985; Jecht et al. -1984;Lunglmayr et al. -1984; Schill u. Landthaler -1981;Torok -1985; Traub u. Thompson -1981), andere haben mit 10 mg (Butt et al. -1978;Willis et al. -1977) oder 30 mg/die (Bartsch u. Schreiber -1981) behandelt. Die Behandlungsdauer war ebenso unterschiedlich (1-12 Monate) wie die Anzahl der Patienten, uber die berichtet wurde. Einige Autoren haben begleitend Normalpersonen behandelt und untersucht (z.B. Comhaire -1976), teils waren es homogene, teils heterogene Patientengruppen, zum Teil waren die Patienten auch vorbehandelt (z.B. operierte Varikozele).

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“…Danner et al -1983); Bartsch u. Schreiber (1981) sowie Jecht e t al. Danner et al -1983); Bartsch u. Schreiber (1981) sowie Jecht e t al.…”

Section: Ergebnisse Und Diskussionunclassified

Section: Z U M P R O B L E M D E R P a T I E N T E N A U S W A H Lunclassified

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Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde

et al. 2009

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“…Certain of these studies have suggested that Tamoxifen increases the sperm density of oligozoospermic males who have normal basal FSH levels (Vermeulen and Comhaire -1978;Buvat et al -1983;Danner et al -1983), whilst others suggest that both sperm density and motility are improved (Schill and Landthaler -1980;Ruiz-Velasco et al -1980;Bartsch and Scheiber -1981). Certain of these studies have suggested that Tamoxifen increases the sperm density of oligozoospermic males who have normal basal FSH levels (Vermeulen and Comhaire -1978;Buvat et al -1983;Danner et al -1983), whilst others suggest that both sperm density and motility are improved (Schill and Landthaler -1980;Ruiz-Velasco et al -1980;Bartsch and Scheiber -1981).…”

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Improvement in Semen Quality in Infertile Males after Treatment with Tamoxifen

et al. 2009

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The effect of the anti-oestrogen Tamoxifen on the seminal quality of 131 men was studied. Parameters studied before and after treatment were sperm density, total ejaculate count, percentage progressive motility, progressively motile ejaculate count, percentage total motility and total motile ejaculate count. In a group of 38 males, the effect on serum LH, FSH, testosterone, oestradiol and prolactin was also studied. Tamoxifen significantly improved (p < 0.05) the progressive motility in all patient groups where there was reduced pretreatment motility. Sperm density was also significantly improved in oligozoospermic patients. Elevations in the basal serum levels of FSH was noted, even in those patients where the basal level was elevated before treatment. Increases were also observed in the serum levels of the four other hormones studied.

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Tamoxifen treatment of oligozoospermia: a re-evaluation of its effects including additional sperm function tests

Sterzik

Rosenbusch

Mogck

et al. 1993

Arch Gynecol Obstet

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Because of previous contradictory results, we reevaluated the effects of tamoxifen on 29 men presenting with idiopathic oligozoospermia. To determine whether a possible increase in sperm concentration might be correlated with an improvement of sperm quality, the hamster ovum penetration (HOP) test and the hypo-osmotic swelling (HOS) test were included as additional tests of sperm function. Patients were treated with tamoxifen (20 mg/day) for 3 months. From 4 weeks until the end of the study, tamoxifen had a significant effect (P < 0.001) on blood levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), and estradiol (E2). Prolactin (PRL) concentrations were not altered significantly (P > 0.05). There was no significant improvement (P > 0.05) of conventional semen parameters (volume, concentration, motility, morphology), and of HOP and HOS test results. The lack of correlation between a rise in hormone levels and improvement of sperm quality suggests that tamoxifen is of questionable value in men with idiopathic oligozoospermia.

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Results of Treatment with Tamoxifen in Oligozoospermie Men

Cited by 15 publications

References 7 publications

Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde

Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie Teil II: Hormonanalysen und Ejakulatbefunde

Improvement in Semen Quality in Infertile Males after Treatment with Tamoxifen

Tamoxifen treatment of oligozoospermia: a re-evaluation of its effects including additional sperm function tests

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