Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects

Torres, Rosângela S. L. A.; Santos, Talita Z.; Torres, Robson A.A.; Pereira, Valéria V.G.; Fávero, Lucas A.F.; Filho, Otávio R. M.; Penkal, Margareth L.; Araujo, Leni S.

doi:10.1016/j.jpedp.2015.04.006

Cited by 18 publications

(36 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Isolates were categorized as indistinguishable, similar or different. In general, “different” was defined as ≤95% similarity and 2 or more band differences; “similar” was defined as ≥95% similarity and 1 band difference; and “indistinguishable” was defined as ≥95% similarity and no band differences (16).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Outbreak of Glomerulonephritis byStreptococcus zooepidemicusSzPHV5 type, in Monte Santo de Minas, Minas Gerais, Brazil

Torres

Santos²,

Bernardes

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

28 Streptococcus zooepidemicus is an emerging and opportunistic zoonotic pathogen, 29 which playsan important role in the development of severe and life-threatening 30 diseases and potentially capable of triggering large glomerulonephritis outbreaks. 31 Between December 2012 and February 2013, 175 cases of glomerulonephritis were 32 confirmed in the town of Monte Santo de Minas / MG / Brazil. During the outbreak, 33 19 isolates of S. zooepidemicus were recovered: one from ice cream, two from the 34 oropharynx of food handlers and 16 from patients affected by acute post streptococcal 35 glomerulonephritis (APSGN). All S. zooepidemicus involved in the outbreak 36 amplified the same sequence of the hypervariable region of the SzP protein (SzPHV5) 37 and presented indistinguishable banding patterns with high similarity (> 99%) by rep-38 PCR technique. Inspection programs on the milk supply chain should be strengthened 39 and continuously encouraged so that consumers' health is preserved. 40 41

show abstract

Section: Methodsmentioning

confidence: 99%

“…This method uses oligonucleotides complementary to repetitive highly conserved DNA sequences present at numerous copies in the bacterial genome. It enables genotypic characterization, clone differentiation, and clone dispersion in the community (15,16).…”

mentioning

confidence: 99%

Outbreak of Glomerulonephritis byStreptococcus zooepidemicusSzPHV5 type, in Monte Santo de Minas, Minas Gerais, Brazil

Torres

Santos²,

Bernardes

et al. 2018

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the early 1980s, more than 40,000 cases were reported per year, with an incidence rate >30/100,000 inhabitants. With the introduction of the DTP vaccine in the Brazilian scheme of childhood vaccination in 1983, this number fell sharply [101]. In 2002, the irst three doses of the DTwP were replaced by the tetravalent vaccine DTwP + H. inluenzae type B (DTwP-Hib), that in 2012 was replaced by the pentavalent DTwP + H. inluenzae type B + hepatitis B (DTwP-Hib-HBV).…”

Section: Back To the Past: Whole Cell Pertussis Vaccine As A New Altementioning

confidence: 99%

Immunization against Pertussis: An Almost Solved Problem or a Headache in Public Health

Dias¹,

Prestes²,

Cunegundes³

et al. 2017

Vaccines

View full text Add to dashboard Cite

Whooping cough or pertussis is a serious infectious disease of the human respiratory tract, caused by Gram-negative bacteria Bordetella pertussis and Bordetella parapertussis HU . The current pertussis vaccines may consist of dead cells of B. pertussis (whole cell pertussis vaccines-wPs) or purified antigens from the bacterium (acellular pertussis vaccines-aPs). The aPs are less reactogenic and have been widely used in developed countries for more than two decades, but their high cost of production makes them prohibitive for developing countries, and the accelerated rate of epidemic outbreaks has led to the hypothesis that aPs are less effective than the wP ones. Considering cost-effectiveness, some authors have pointed out questions about the possibility of reintroduction of wP vaccines into the primary doses of pertussis vaccination. The Butantan Institute in São Paulo, Brazil, developed a wP vaccine with low endotoxicity (Plow) obtained by chemical extraction of the lipooligosaccharide (LOS) fraction from the outer membrane of the bacterial cell, showing to be less reactogenic and equally immunogenic and protective as the traditional wP vaccine. The Plow may possibly be introduced into the vaccination schedule for immunization of adolescents and young adults in Brazil, an important epidemiological contribution to reducing the circulation of B. pertussis.

show abstract

“…Um estudo observacional e transversal, realizado no Paraná, revelou que entre 2007 e 2013 a prevalência da doença em crianças menores de 1 ano foi de 67.5%. 5 Os fatores de risco para óbito são idade inferior a um ano, hiperleucocitose, pneumonia, convulsões e calendário vacinal incompleto. A taxa de mortalidade nesse grupo etário varia entre 0.8% e 6.7%.…”

Section: Introductionunclassified

O atual e preocupante perfil epidemiológico da coqueluche no Brasil - The current and worrisome epidemiology of pertussis in Brazil

Silva¹,

Graciano²,

Montalvão³

et al. 2017

RESU

View full text Add to dashboard Cite

Objective: To analyze the prevalence of pertussis (whooping cough) in Brazil between 2000 and 2014, and the mortality rate between 2000 and 2013, correlating with the distribution by sex and age group. Methods: Analytical ecological study with temporal design. For data collection, were used as sources SIH, SIM, SINAN and IBGE. The variables analyzed were gender and age. Results: There was a great increase in whooping cough prevalence in Brazil. In 2000, the prevalence in 100.000 inhabitants was 0.5 (95% CI: 0.48 -0.54), jumping in 2014, to 2.43 (95% CI: 2.36 -2.50). Children under one year are the most affected. Both sexes presented a higher prevalence rate in 2014, when male sex reached a rate of 2.3 (95% CI: 2.21 -2.4) and, the female, 2.55 for every 100,000 (95% CI: 2.46 -2.65). The mortality rate for whooping cough increased during the study period. In 2000, the rate was 0.53 per 100.000 inhabitants (95% CI: 0.23 -1.24), reaching the minimum in 2006, with a value of 0.1 (95% CI: 0.2 -0.55). The mortality from the disease reached the higher value in the following year, in 2007, with a rate of 13.46 (95% CI: 11.41 -15.87). Conclusions:The panorama of whooping cough in Brazil has been unfavorable in the last years, since the prevalence and the mortality increased considerably in the period of time studied. Children younger than 1 year are the most affected by the disease, which does not show a significant predilection when it comes to sex.

show abstract

Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects

Cited by 18 publications

References 16 publications

Outbreak of Glomerulonephritis byStreptococcus zooepidemicusSzPHV5 type, in Monte Santo de Minas, Minas Gerais, Brazil

Outbreak of Glomerulonephritis byStreptococcus zooepidemicusSzPHV5 type, in Monte Santo de Minas, Minas Gerais, Brazil

Immunization against Pertussis: An Almost Solved Problem or a Headache in Public Health

O atual e preocupante perfil epidemiológico da coqueluche no Brasil - The current and worrisome epidemiology of pertussis in Brazil

Contact Info

Product

Resources

About