Resuscitation strategies from bupivacaine‐induced cardiac arrest

Mauch, Jacqueline; Jurado, Olga Martin; Spielmann, Nelly; Bettschart‐Wolfensberger, Regula; Weiß, Markus

doi:10.1111/j.1460-9592.2011.03688.x

Cited by 28 publications

(27 citation statements)

References 16 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In cardiac arrest caused by bupivacaine intoxication, firstline rescue with epinephrine and epinephrine + Intralipid(®) was more effective with regard to survival than Intralipid(®) alone and vasopressin + Intralipid(®) in this pig model (9).…”

Section: The Lipid Sink Effectmentioning

confidence: 88%

See 1 more Smart Citation

Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS)

Eldor¹,

Kotlovker²

2012

J Anesthesiol Clin Sci

View full text Add to dashboard Cite

On 1998 it was first showed that intravenous intralipid could prevent or improve resuscitation from cardiovascular collapse by severe bupivacaine overdose in rats. Since then published examples now include toxicities related to verapamil, diltiazem, amlodipine, quetiapine and sertraline, haldoperidol, lamotrigine, olanzapine, propranolol, atenolol, nevibolol, doxepin, dosulepin, imipramine, amitriptyline, glyosphate herbicide, flecainide, venlafaxine, moxidectin, and others. Intralipid treatment is a new treatment for Bone cement implantation syndrome (BCIS) which was never suggested before. Animal studies should be done in order to evaluate this new treatment modality.

show abstract

Section: The Lipid Sink Effectmentioning

confidence: 88%

“…Lipid resuscitation has been recommended for the treatment of LA-induced cardiac arrest. Aim of the study [9] was to compare four different rescue regimens using epinephrine and/or lipid emulsion and vasopressin to treat cardiac arrest caused by bupivacaine intoxication.…”

Section: The Lipid Sink Effectmentioning

confidence: 99%

Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS)

Eldor¹,

Kotlovker²

2012

J Anesthesiol Clin Sci

View full text Add to dashboard Cite

show abstract

Section: The Intralipid Sink Effectmentioning

confidence: 93%

Can intralipid infusion open a coronary occlusion causing acute myocardial infarction?

Eldor¹

2017

Clin Med Invest

View full text Add to dashboard Cite

Coronary heart disease remains the leading cause of morbidity and mortality in Western countries. The best hope of salvaging viable myocardium after a coronary occlusion is by rapid reperfusion of the ischemic myocardium, either by thrombolysis or primary percutaneous coronary intervention. The use of intravenous intralipid infusion instead of thrombolysis or primary percutaneous coronary intervention is first suggested in the medical literature.Correspondence to: Joseph Eldor, Theoretical Medicine Institute, Jerusalem, Israel, E-mail: csen_international@csen.com Key words: intralipid, myocardial infarction, coronary occlusionReceived: June 18, 2017; Accepted: July 15, 2017; Published: July 17, 2017 Thrombolysis or primary percutaneous coronary intervention or Intralipid Infusion?Coronary heart disease remains the leading cause of morbidity and mortality in Western countries. The best hope of salvaging viable myocardium after a coronary occlusion is by rapid reperfusion of the ischemic myocardium, either by thrombolysis or primary percutaneous coronary intervention. Although reperfusion restores blood flow, oxygen, and nutrients to the cardiac muscle, it also has the potential to induce reperfusion injury.Postconditioning of the heart with brief episodes of reperfusion/ occlusion at the onset of reflow has been shown to limit infarct size. However, this approach is not practical for patients treated with thrombolytic agents and therefore a more generic pharmacologic postconditioning is still needed. The ideal pharmacologic candidates need to be safe and effective when administered during the first few minutes of reperfusion by inducing cellular protection or enhancing myocardial tolerance to ischemia/reperfusion injury. Several drugs have yielded encouraging results in animals and a few have been tested in humans; however, none of these modalities has been widely accepted.Lipids and in particular polyunsaturated fatty acids have received special cardiovascular research attention because polyunsaturated fatty acid-rich diets are associated with a decreased risk of coronary artery disease. Acute application of polyunsaturated fatty acids to cardiomyocytes has also been shown to shorten action potential duration and this could account for the antiarrhythmic mechanism of the polyunsaturated fatty acids. Intralipid (Sigma, St. Louis, MO) is a brand name for the first safe fat emulsion for human use; Intralipid 20% is an emulsion of soybean oil (20%), egg yolk phospholipids (1.2%), and glycerol (2.2%). Intralipid has been widely used in patients who need total parenteral nutrition and as a vehicle for different drugs such as propofol. It has been shown recently that postischemic administration of Intralipid protects the isolated rat heart against ischemia/reperfusion injury. However, the molecular mechanism in which Intralipid mediates cardioprotection is completely unknown [1].Intralipid, a brand name for the first safe fat emulsion for human use, has been shown to be cardioprotective. However, the mechanism ...

show abstract

“…Previous studies using a swine model have not produced a hypersensitivity syndrome, and yet intravenous lipid emulsion has been effective. 13,[20][21][22][23] In our study, we observed transient skin flushing in 1 intravenous lipid emulsion pig. This pig died approximately 6 minutes after intravenous lipid emulsion infusion, similar to other animals.…”

Section: Limitationsmentioning

confidence: 98%

Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model

Varney

Bebarta

Boudreau

et al. 2016

Annals of Emergency Medicine

View full text Add to dashboard Cite

Resuscitation strategies from bupivacaine‐induced cardiac arrest

Abstract: In cardiac arrest caused by bupivacaine intoxication, first-line rescue with epinephrine and epinephrine + Intralipid(®) was more effective with regard to survival than Intralipid(®) alone and vasopressin + Intralipid(®) in this pig model.

Cited by 28 publications

References 16 publications

Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS)

Intralipid treatment: Is it only the tip of an iceberg? A new suggestion: Bone cement implantation syndrome (BCIS)

Can intralipid infusion open a coronary occlusion causing acute myocardial infarction?

Intravenous Lipid Emulsion Therapy for Severe Diphenhydramine Toxicity: A Randomized, Controlled Pilot Study in a Swine Model

Contact Info

Product

Resources

About