Resuscitative effect of centhaquin after hemorrhagic shock in rats

Pharmacokinetics of centhaquin citrate in a rat model

“…Centhaquin citrate is a novel resuscitative agent in development for haemorrhagic shock. Previously, we conducted efficacy studies in rats that were bled to a fixed pressure of 35 mmHg for 30 min before initiation of resuscitation with centhaquin citrate . The present study is the first to our knowledge to describe the pharmacokinetic properties of centhaquin citrate in rats and demonstrated that a two‐compartment structural model best fit the data.…”

“…As we have previously described, low doses of centhaquin (2‐[2‐(4‐(3‐methylphenyl)‐1‐piperazinyl)]ethyl‐quinoline) citrate, when added to either lactated Ringer's solution (LR) or hypertonic saline (HS), significantly decreased blood lactate and increased mean arterial pressure (MAP), pulse pressure (PP) and cardiac output (CO) compared to LR and HS alone. In a rat model of fixed pressure blood loss, we demonstrated that centhaquin citrate, a cardiovascular active agent, is highly effective in reducing mortality following hypovolaemic shock . Animals treated with centhaquin citrate experienced decreased heart rates (HR) and no change or decrease in vascular resistance; however, animals that received centhaquin citrate experienced markedly increased MAP due to increased CO compared to controls.…”

Oxidative stress in severe pulmonary trauma in critical ill patients. Antioxidant therapy in patients with multiple trauma — a review

“…Inadequate resuscitation and the complications that may arise in this case, makes the recovery of the patient hard or impossible [69][70][71]. An aggressive and inadequate fluids resuscitation can produce high quantities of reactive species of oxygen through the re-oxygenation of the tissue [15].…”

Pharmacokinetics of centhaquin citrate in a dog model

“…Centhaquin (2‐[2‐(4‐(3‐methyphenyl)‐1‐piperazinyl)]ethyl‐quinoline) is a centrally acting cardiovascular active agent with positive inotropic effects. Previously, centhaquin has been shown to significantly improve survival in several animal models of hypovolemic shock . Low doses of centhaquin can significantly decrease blood lactate, increase mean arterial pressure (MAP) and improve cardiac output (CO) parameters that are central to the management of patients with haemorrhagic shock .…”

“…Previously, centhaquin has been shown to significantly improve survival in several animal models of hypovolemic shock . Low doses of centhaquin can significantly decrease blood lactate, increase mean arterial pressure (MAP) and improve cardiac output (CO) parameters that are central to the management of patients with haemorrhagic shock . Centhaquin is thought to act at the α 2B ‐adrenergic receptors to produce venous constriction with a subsequent increase in venous return to the heart .…”