Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation

Wu, Yan; Jia, Lili; Zheng, Yin; Xu, Xiaowen; Ying, Luo; Wang, B.; Chen, J.Z.S.; Gao, Xinghua; Chen, H.-D.; Matsui, Mary S.; Li, Y.-H.

doi:10.1111/j.1468-3083.2011.04414.x

Cited by 44 publications

(33 citation statements)

References 22 publications

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“…Resveratrol is widely present in natural sources such as grapes, berries, and nuts and possesses various activities including anticancer properties, extension of lifespan (Baur and Sinclair, 2006), and antihyperpigmentation (Wu et al ., 2012). Depigmentation agents commonly have similar phenol-based structures, which can inhibit tyrosinase activity (Newton et al ., 2007).…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Lee

Seo

Baek

et al. 2014

Biomolecules & Therapeutics

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Resveratrol is a polyphenolic compound found in various natural products such as grapes and berries and possesses anti-cancer, anti-hyperlipidemia, and anti-aging properties. Recently, it has been reported that resveratrol inhibits α-melanocyte-stimulating hormone signaling, viability, and migration in melanoma cells. However, these effects have not been confirmed in vivo, specifically brownish guinea pigs. To evaluate the potential of resveratrol as a regulator of melanin for hyperpigmentation therapy, the influence of resveratrol on pigmentation was investigated by ultraviolet B-induced hyperpigmentation in brownish guinea pig skin. We found that resveratrol reduced the expression of melanogenesis-related proteins tyrosinase, tyrosinase-related proteins 1 and 2, and microphthalmia-associated transcription factor in melanoma cells. Furthermore, topical application of resveratrol was demonstrated to significantly decrease hyperpigmentation on ultraviolet B-stimulated guinea pig skin in vivo. Based on our histological data, resveratrol inhibits melanin synthesis via a reduction in tyrosinase-related protein 2 among the melanogenic enzymes. This study is the first to provide evidence supporting resveratrol as a depigmentation agent, along with further clinical investigation of resveratrol in ultraviolet B-induced skin disorders such as hyperpigmentation and skin photoaging.

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Lee

Seo

Baek

et al. 2014

Biomolecules & Therapeutics

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“…Recently, Wu et al [303] reported the protective effect of RES triphosphate against UV-induced erythema. Different moisturizing cream preparations were assayed in 15 healthy females.…”

Section: Human Intervention Studiesmentioning

confidence: 99%

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

Tomé‐Carneiro

Larrosa²,

González‐Sarrías

et al. 2013

CPD

397

294

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Resveratrol (3,5,4’-trihydroxy-trans-stilbene) is a non-flavonoid polyphenol that may be present in a limited number of food-stuffs such as grapes and red wine. Resveratrol has been reported to exert a plethora of health benefits through many different mechanisms of action. This versatility and presence in the human diet have drawn the worldwide attention of many research groups over the past twenty years, which has resulted in a huge output of in vitro and animal (preclinical) studies. In line with this expectation, many resveratrol-based nutraceuticals are consumed all over the world with questionable clinical/scientific support. In fact, the confirmation of these benefits in humans through randomized clinical trials is still very limited. The vast majority of preclinical studies have been performed using assay conditions with a questionable extrapolation to humans, i.e. too high concentrations with potential safety concerns (adverse effects and drug interactions), short-term exposures, in vitro tests carried out with non-physiological metabolites and/or concentrations, etc. Unfortunately, all these hypothesis-generating studies have contributed to increased the number of ‘potential’ benefits and mechanisms of resveratrol but confirmation in humans is very limited. Therefore, there are many issues that should be addressed to avoid an apparent endless loop in resveratrol research. The so-called ‘Resveratrol Paradox’, i.e., low bioavailability but high bioactivity, is a conundrum not yet solved in which the final responsible actor (if any) for the exerted effects has not yet been unequivocally identified. It is becoming evident that resveratrol exerts cardioprotective benefits through the improvement of inflammatory markers, atherogenic profile, glucose metabolism and endothelial function. However, safety concerns remain unsolved regarding chronic consumption of high RES doses, specially in medicated people. This review will focus on the currently available evidence regarding resveratrol’s effects on humans obtained from randomized clinical trials. In addition, we will provide a critical outlook for further research on this molecule that is evolving from a minor dietary compound to a possible multi-target therapeutic drug.

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“…Although human studies are still limited, topical application of RSV protects human skin from the effects of sun damage by decreasing the formation of sunburn cells (Polonini et al, 2013; Wu et al, 2013). There was improvement in the moisture of the skin and its elasticity, an amelioration of skin roughness and depth of wrinkles, combined with a reduction of age-spots color intensity (Buonocore et al, 2012).…”

Section: Resveratrol and Skin Disordersmentioning

confidence: 99%

Resveratrol supplementation: Where are we now and where should we go?

Novelle¹,

Wahl²,

Diéguez³

et al. 2015

Ageing Research Reviews

214

149

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Pre-clinical findings have provided mounting evidence that resveratrol, a dietary polyphenol, may confer health benefits and protect against a variety of medical conditions and age-related complications. However, there is no consistent evidence of an increased protection against metabolic disorders and other ailments when comparing studies in laboratory animals and humans. A number of extraneous and potential confounding variables can affect the outcome of clinical research. To date, most of the studies that have investigated the effect of resveratrol administration on patient outcomes have been limited by their sample sizes. In this review we will survey the latest advances regarding the timing, dosage, formulation, bioavailability, and toxicity of resveratrol, and resveratrol-drug interactions in human studies. Moreover, the present report focuses on the actions of resveratrol treatment in combatting diseases, such as cancer, diabetes, neurodegeneration, cardiovascular disease, and other age-related ailments.

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Resveratrate protects human skin from damage due to repetitive ultraviolet irradiation

Abstract: Resveratrate exerts protective effects against repetitive ssUVR-induced sunburn and suntan.

Cited by 44 publications

References 22 publications

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Inhibitory Effects of Resveratrol on Melanin Synthesis in Ultraviolet B-Induced Pigmentation in Guinea Pig Skin

Resveratrol and Clinical Trials: The Crossroad from In Vitro Studies to Human Evidence

Resveratrol supplementation: Where are we now and where should we go?

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