Resveratrol: A potential challenger against gastric cancer

Abstract

Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer-related mortality in the world. Late diagnosis and classical therapeutic approaches such as surgery, chemotherapy and radiotherapy make this disease a still threatening tumor. Genetic asset, environmental stress, dietary habit and infections caused by Helicobacter pylori (H. pylori) are the major causes concurring to GC initiation. A common mechanism is induction of radicals resulting in gastric mucosal injury. A regular food intake of antioxidant and radical scavenging agents has been proposed to exert protection against tumorigenesis. Resveratrol belongs to the polyphenol flavonoids class of antioxidants produced by a restricted number of plants. Resveratrol exerts bactericidal activity against H. pylori and is a powerful antioxidant, thus acting as a tumor preventive agent. Resveratrol intracellular signaling results in growth arrest and apoptosis, so that it can be directed against tumor progression. Resveratrol therapeutic potential against GC initiation and progression are reviewed here.

QKI5-mediated alternative splicing of the histone variant macroH2A1 regulates gastric carcinogenesis

“…GC is the fourth most commonly diagnosed cancer and the second lethal malignancy worldwide; it is the most common gastrointestinal malignancy in East Asia and Eastern Europe [35]. GC is often diagnosed at the advanced stage, accompanied with malignant cell growth and metastasis.…”

The resveratrol derivatives trans-3,5-dimethoxy-4-fluoro-4′-hydroxystilbene and trans-2,4′,5-trihydroxystilbene decrease oxidative stress and prolong lifespan in Caenorhabditis elegans

“…Resveratrol ( trans ‐3,4′,5‐trihydroxystilbene) is a naturally occurring phytoalexin which can be found in various plants, for example grapes. This compound is discussed to mediate numerous beneficial effects to human health, such as protection against morbus Alzheimer, macular degeneration as well as cancer . As this compound can be found in relatively high concentrations in red wine, it is claimed to be responsible for beneficial effects associated with a modest consumption of red wine (the so‐called French paradox).…”

Protective effect of autologous transplantation of resveratrol preconditioned adipose‐derived stem cells in the treatment of diabetic liver dysfunction in rat model

“…Resveratrol is one of polyphenols found in grape and red wine. Experimental results from in vitro and in vivo reveal that resveratrol shows beneficial effects on antioxidant, cardiac protection, antitumor, and antiaging (Bhullar & Hubbard, ; Jiménez‐Osorio, González‐Reyes, & Pedraza‐Chaverri, ; Liu, Tsai, Tsai, & Yu, ; Raj et al, ; Ramis, Esteban, Miralles, Tan, & Reiter, ; Zulueta, Caretti, Signorelli, & Ghidoni, ). Zhang et al () pointed out that resveratrol reduces stem cell damage induced by ROS through activation of Sirt1/SOD2 antioxidant pathway.…”