Resveratrol accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration

Zhou, Xueqing; Ruan, Qiongfang; Ye, Ziqing; Chu, Zhigang; Xi, Maomao; Li, Min; Hu, Weigang; Guo, Xiaoyu; Yao, Paul; Xie, Weiguo

doi:10.1016/j.burns.2020.10.016

Cited by 68 publications

(44 citation statements)

References 18 publications

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“…Many studies have been done to discover natural chemicals which can cure diabetic wounds. There has been increasing evidence that resveratrol (RSV) plays an important role in promoting skin healing in diabetic wounds, for instance, by activating SIRT 1 pathway and potentially upregulating nuclear Nrf2 and Mn-SOD [1,4].…”

Section: ■ Introductionmentioning

confidence: 99%

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Analytical Method Validation and Formula Optimization of Topical Nanoemulsion Formulation Containing Resveratrol

Nastiti

Riswanto

2021

Indones. J. Chem.

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Resveratrol (RSV), a natural lipophilic phytoalexin, was reported as an antioxidant and anti-inflammatory agent, which has the potential to cure diabetic wounds. However, several studies suggested the limitation of RSV, such as poor aqueous solubility, poor stability, and poor oral bioavailability. To overcome the issues, RSV was formulated as a topical nanoemulsion. It is important to ensure the quality of the dosage form by evaluating RSV load in the nanoformulation and optimizing the formula. A reversed-phase HPLC method was developed and validated prior to the load determination of RSV in the nanoemulsion formulation. The composition of triacetin-eugenol, Kolliphor® RH 40, and Transcutol® was further optimized by employing a Box-Behnken Design (BBD) to achieve the optimum composition with expected viscosity and RSV load. The HPLC method for determining RSV load was successfully validated for parameters of selectivity with the resolution of 8.487, linearity and range (r = 0.9979), precision (0.12% of RSD), accuracy (109–110% of recovery), the limit of detection (0.574 µg/mL), and limit of quantitation (1.740 µg/mL). The result of formula optimization was promising, showing the optimum composition of triacetin-eugenol, Kolliphor® RH 40, and Transcutol® at 4.44 g, 30.97 g, and 11.39 g, respectively.

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Section: ■ Introductionmentioning

confidence: 99%

“…Apart from the potential therapeutic benefits of RSV, as a lipophilic antioxidant, the aqueous solubility of RSV is very limited, and RSV is prone to chemical instability [4,18]. The oral administration of RSV is also challenging, reflecting poor bioavailability due to excessive hepatic first-pass elimination [19].…”

Section: ■ Introductionmentioning

confidence: 99%

Analytical Method Validation and Formula Optimization of Topical Nanoemulsion Formulation Containing Resveratrol

Nastiti

Riswanto

2021

Indones. J. Chem.

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“…Therapeutic strategies of diabetic wound healing targeting the SIRT1 have been reported in recent years. Resveratrol, a well-known SIRT1 activator, accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration ( Zhou et al, 2021 ). SIRT1 inhibits the expression of matrix metalloproteinase-1 and −3, delaying wound healing.…”

Section: Antioxidant Therapy In Diabetic Wound Healingmentioning

confidence: 99%

Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing

Zhang

Chen

Xiong

et al. 2021

Front. Bioeng. Biotechnol.

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Ulcers are a lower-extremity complication of diabetes with high recurrence rates. Oxidative stress has been identified as a key factor in impaired diabetic wound healing. Hyperglycemia induces an accumulation of intracellular reactive oxygen species (ROS) and advanced glycation end products, activation of intracellular metabolic pathways, such as the polyol pathway, and PKC signaling leading to suppression of antioxidant enzymes and compounds. Excessive and uncontrolled oxidative stress impairs the function of cells involved in the wound healing process, resulting in chronic non-healing wounds. Given the central role of oxidative stress in the pathology of diabetic ulcers, we performed a comprehensive review on the mechanism of oxidative stress in diabetic wound healing, focusing on the progress of antioxidant therapeutics. We summarize the antioxidant therapies proposed in the past 5 years for use in diabetic wound healing, including Nrf2- and NFκB-pathway-related antioxidant therapy, vitamins, enzymes, hormones, medicinal plants, and biological materials.

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“…Among these, the positive effect of polyphenols on tissue regeneration in some vegetable species is well documented. For instance, it has been found that resveratrol, widely present in grapes and red wine, can control oxidative stress, stimulating wound healing and diminishing the inflammatory response [ 16 ]. Proanthocyanidins in berries and curcumin in turmeric have also been found to shorten the inflammatory phase and favor wound healing by reducing the production of tumor necrosis factor-α (TNFα), interleukuin-1 (IL-1), and/or reactive oxygen species (ROS) [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo‐Rodríguez

Luna-Bertos

Ramos‐Torrecillas

et al. 2021

Foods

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The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition.

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Resveratrol accelerates wound healing by attenuating oxidative stress-induced impairment of cell proliferation and migration

Cited by 68 publications

References 18 publications

Analytical Method Validation and Formula Optimization of Topical Nanoemulsion Formulation Containing Resveratrol

Analytical Method Validation and Formula Optimization of Topical Nanoemulsion Formulation Containing Resveratrol

Antioxidant Therapy and Antioxidant-Related Bionanomaterials in Diabetic Wound Healing

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

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