Resveratrol Activates Membrane-Bound Guanylyl Cyclase in Coronary Arterial Smooth Muscle: A Novel Signaling Mechanism in Support of Coronary Protection

El‐Mowafy, Abdalla M.

doi:10.1006/bbrc.2002.6598

Cited by 52 publications

(28 citation statements)

References 23 publications

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“…Concerning the cGMP pathway, resveratrol increases cGMP in coronary arteries, mostly by activation of pGC [94]. Resveratrol activates membrane-bound guanylate cyclase GC-A, the receptor for atrial natriuretic factor (ANF) [95].…”

Section: Resveratrol and Vasorelaxationmentioning

confidence: 99%

Resveratrol: Preventing properties against vascular alterations and ageing

Delmas

Jannin

Latruffe³

2005

Mol. Nutr. Food Res.

253

143

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Cardiovascular diseases are the leading cause of death in developed countries where the common pathological substrate underlying this process is atherosclerosis. Several new concepts have emerged in relation to mechanisms that contribute to the regulation of the vascular diseases and associated inflammatory effects. Recently, potential antioxidants (vitamin E, polyphenols) have received much attention as potential anti-atherosclerotic agents. Among the polyphenols with health benefic properties, resveratrol, a phytoalexin of grape, seem to be a good candidate protecting the vascular walls from oxidation, inflammation, platelet aggregation, and thrombus formation. In this review, we focus on the mechanism of resveratrol cardiovascular benefic effects. We analyze, in relation with the different steps of atherosclerotic process, the resveratrol properties at multiple levels, such as cellular signaling, enzymatic pathways, apoptosis, and gene expression. We show and discuss the relationship with reactive oxygen species, regulation of pro-inflammatory genes including cycloxygenases and cytokines in molecular inflammatory and aging processes, and how the regulation of these activites by resveratrol can lead to a prevention of vascular diseases.

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Section: Resveratrol and Vasorelaxationmentioning

confidence: 99%

Resveratrol: Preventing properties against vascular alterations and ageing

Delmas

Jannin

Latruffe³

2005

Mol. Nutr. Food Res.

253

143

View full text Add to dashboard Cite

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“…It is possible that resveratrol might protect the heart from ischemia-reperfusion injury, decrease plasma triglyceride and cholesterol accumulation in the aorta and prevent atherosclerosis [5,6] . Moreover, resveratrol has been found to relax the coronary arteries [7,8] . Recently, we found that resveratrol decreased the amplitude of action potential (APA), overshoot (OS) and maximal velocity of phase 0 depolarization (V max ) in partially depolarized papillary muscles [9] .…”

Section: Introductionmentioning

confidence: 99%

Effect of resveratrol on L-type calcium current in rat ventricular myocytes

Zhang

Yin

Liu

et al. 2006

Acta Pharmacologica Sinica

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“…This triggers vasorelaxant responses even in endothelium-disrupted arteries. 11 RSVL prevented bradykinin-induced contraction of rat urinary bladder smooth muscle by the inhibition of Ca 2+ influx. 12 Wang et al 13 showed that RSVL had an inhibitory effect on guinea pig gallbladder contractility.…”

Section: Introductionmentioning

confidence: 81%

“…The use of fulvestrant demonstrated that this effect of RSVL was not mediated through estrogen receptors which had been suggested by other researchers. [3][4][5] El Mowafy 11 showed that RSVL increased cGMP in sheep coronary arteries which led to an endothelium-independent vasodilation. In the guinea pig gallbladder strips the use of KT5823, a PKG antagonist, had no significant effect on the amount of RSVL-induced relaxation.…”

Section: Discussionmentioning

confidence: 99%

The Resveratrol-induced Relaxation of Cholecystokinin Octapeptide- or KCl-induced Tension in Male Guinea Pig Gallbladder Strips Is Mediated Through L-type Ca2+ Channels

Kline

Karpinski

2015

J Neurogastroenterol Motil

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Background/Aims Resveratrol (3,5,4′-trihydroxystilbene) is a polyphenolic compound (stilbene) and a phytoalexin. The purpose of this study was to determine the mechanism which mediated the resveratrol-induced relaxation of cholecystokinin octapeptide- or KCl-induced tension in male guinea pig gallbladder strips. Methods Gallbladder strips were prepared and suspended in in vitro chambers filled with Krebs-Henseleit solution. The strips were attached to force displacement transducers, and the changes in tension were recorded on a polygraph. All reagents were added directly into the chambers. Results To determine if intracellular Ca 2+ release mediated the resveratrol-induced relaxation of cholecystokinin octapeptide-induced tension, 2-aminoethoxydiphenylborane (2-APB) was used. 2-APB significantly ( P < 0.01) decreased the amount of RSVL-induced relaxation. To determine if protein kinase A (PKA) mediated the resveratrol-induced relaxation, PKA inhibitor 14-22 amide myristolated (PKA-IM) was used. PKA-IM had no effect on resveratrol-induced relaxation. Neither KT5823, N G -methyl-L-arginine acetate salt, a nitric oxide synthase inhibitor, nor fulvestrant had a significant effect on the amount of resveratrol-induced relaxation. Genistein, a protein tyrosine kinase inhibitor, significantly ( P < 0.01) increased the RSVL-induced relaxation. To determine if protein kinase C mediated the RSVL-induced relaxation, the protein kinase C inhibitors bisindolymaleimide IV and chelerythrine Cl- were used together, and a significant ( P < 0.05) increase in resveratrol-induced relaxation was observed. The pretreatment of the strips with resveratrol significantly ( P < 0.001) decreased the amount of KCl- and cholecystokinin octapep-tide-induced tension. Conclusions Resveratrol-induced relaxation is mediated by its effects on L-type Ca 2+ channels and intracellular Ca 2+ release.

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Resveratrol Activates Membrane-Bound Guanylyl Cyclase in Coronary Arterial Smooth Muscle: A Novel Signaling Mechanism in Support of Coronary Protection

Cited by 52 publications

References 23 publications

Resveratrol: Preventing properties against vascular alterations and ageing

Resveratrol: Preventing properties against vascular alterations and ageing

Effect of resveratrol on L-type calcium current in rat ventricular myocytes

The Resveratrol-induced Relaxation of Cholecystokinin Octapeptide- or KCl-induced Tension in Male Guinea Pig Gallbladder Strips Is Mediated Through L-type Ca2+ Channels

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