Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials

Drygalski, Krzysztof; Fereniec, Eliza; Koryciński, Krzysztof; Chomentowski, Andrzej; Kiełczewska, Aleksandra; Odrzygóźdź, Cezary; Modzelewska, Beata

doi:10.1016/j.exger.2018.09.019

Cited by 47 publications

(30 citation statements)

References 113 publications

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“…This natural phenolic compound is produced by several plants either in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Numerous studies have demonstrated that RSV possesses a wide range of biological properties such as cardioprotection, 2,3 anti-inammatory and antioxidant activities, [4][5][6][7] among others. However, the application of RSV in pharmaceutical and food industries is usually limited owing to its low water solubility, and rapid UV-induced isomerization to the inactive biologically isomer (cis isomer).…”

Section: Introductionmentioning

confidence: 99%

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

et al. 2019

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Section: Introductionmentioning

confidence: 99%

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

et al. 2019

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“…About misfolding protein aggregations, various Sirtuin 1 (Sirt1) enhancers have been proven to reduce misfolding protein-induced neurotoxicity, such as resveratrol, SRT1460, and SRT1720 (Drygalski et al, 2018;Min et al, 2018). One approach using BACE1 inhibitors in AD was promising few years ago, but the increase of BACE1 expression by any BACE1 inhibitors raises concern about their use for AD (Liu et al, 2019).…”

Section: Therapeutic Approachesmentioning

confidence: 99%

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

et al. 2020

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Although the basis of Alzheimer's disease (AD) etiology remains unknown, oxidative stress (OS) has been recognized as a prodromal factor associated to its progression. OS refers to an imbalance between oxidant and antioxidant systems, which usually consist in an overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) which overwhelms the intrinsic antioxidant defenses. Due to this increased production of ROS and RNS, several biological functions such as glucose metabolism or synaptic activity are impaired. In AD, growing evidence links the ROS-mediated damages with molecular targets including mitochondrial dynamics and function, protein quality control system, and autophagic pathways, affecting the proteostasis balance. In this scenario, OS should be considered as not only a major feature in the pathophysiology of AD but also a potential target to combat the progression of the disease. In this review, we will discuss the role of OS in mitochondrial dysfunction, protein quality control systems, and autophagy associated to AD and suggest innovative therapeutic strategies based on a better understanding of the role of OS and proteostasis.

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“…Recently many studies are focusing on RSV, as molecule more in view in the field of the lifestyle-related diseases, including AD [160]. This interest is mainly due to its beneficial effect against oxidative stress and neuroinflammation, by modulating proteins that are closely related to neurological disorders, i.e., AMPK, sirtuin-1 pathway (SIRT1) and receptor-gamma coactivator 1α (PGC-1α) [140,160] (Figure 3).…”

Section: Resveratrol (Rsv)mentioning

confidence: 99%

“…The key neuroprotective mechanism of RSV in AD appears to be related to the activation of SIRT1 [160]. SIRT1 regulates the activity of several substrates, including p53 and the peroxisome proliferator-activated PGC-1α [161], a substrate able to improve mitochondrial dysfunction [162].…”

Section: Resveratrol (Rsv)mentioning

confidence: 99%

“…Moreover, activation of SIRT1 leads to inhibition of nitric oxide synthase (iNOS), which becomes active in response to cell damage and NF-κB signaling. The iNOS inhibition occurs in a double way: via a direct inhibition by SIRT1 or through SIRT1 related activation of suppressor of cytokine signaling 1 (SOCS1) [160]. Both ways lead to a decrease in iNOS expression, and thus to a drop in the NO synthesis, which in the presence of ROS can create the highly neurotoxic reactive nitrogen species, such as peroxynitrous acid (ONOOH), nitrogen dioxide (•NO 2 ) or dinitrogen trioxide (N 2 O 3 ) [160] ( Figure 3).…”

Section: Resveratrol (Rsv)mentioning

confidence: 99%

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Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

Atlante

Amadoro

Bobba

et al. 2020

Cells

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A new epoch is emerging with intense research on nutraceuticals, i.e., “food or food product that provides medical or health benefits including the prevention and treatment of diseases”, such as Alzheimer’s disease. Nutraceuticals act at different biochemical and metabolic levels and much evidence shows their neuroprotective effects; in particular, they are able to provide protection against mitochondrial damage, oxidative stress, toxicity of β-amyloid and Tau and cell death. They have been shown to influence the composition of the intestinal microbiota significantly contributing to the discovery that differential microorganisms composition is associated with the formation and aggregation of cerebral toxic proteins. Further, the routes of interaction between epigenetic mechanisms and the microbiota–gut–brain axis have been elucidated, thus establishing a modulatory role of diet-induced epigenetic changes of gut microbiota in shaping the brain. This review examines recent scientific literature addressing the beneficial effects of some natural products for which mechanistic evidence to prevent or slowdown AD are available. Even if the road is still long, the results are already exceptional.

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Resveratrol and Alzheimer's disease. From molecular pathophysiology to clinical trials

Cited by 47 publications

References 113 publications

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

Niosomes encapsulated in biohydrogels for tunable delivery of phytoalexin resveratrol

Interplay Between Mitochondrial Oxidative Disorders and Proteostasis in Alzheimer’s Disease

Functional Foods: An Approach to Modulate Molecular Mechanisms of Alzheimer’s Disease

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