Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress

El-Fattah, Amal Ahmed Abd; Fahim, Atef T.; Sadik, Nermin Abdel Hamid; Ali, Bassam Mohamed

doi:10.1016/j.brainres.2018.09.027

Cited by 62 publications

(43 citation statements)

References 67 publications

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“…26 There is evidence demonstrating that the dysregulation (ie, hyperactivity and redox disturbances) of neutrophils from patients with chronic periodontitis is associated with a defect in binding of nuclear factor erythroid 2-related factor 2 DNA, suggesting that a disruption in the nuclear factor erythroid 2-related factor 2 pathway is a potential mechanism leading to the cellular redox imbalance observed in this disease. 215 The role of different levels of nuclear factor erythroid 2-related factor 2 in periodontal disease has been investigated over the years, 26,122,216 and the positive effects of resveratrol on the levels of nuclear factor erythroid 2-related factor 2 in different tissues [217][218][219] have also been investigated. However, the effects of resveratrol on the nuclear factor erythroid 2-related factor 2 pathway, specifically with respect to periodontitis, have yet to be addressed in detail.…”

Section: Nuclear Factor Erythroid 2-related Factor 2-related Pathwaymentioning

confidence: 99%

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Sczepanik

Grossi

Casati

et al. 2020

Periodontology 2000

346

244

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Periodontitis is a highly prevalent disease. As it progresses, it causes serious morbidity in the form of periodontal abscesses and tooth loss and, in the latter stages, pain. It is also now known that periodontitis is strongly associated with several nonoral diseases. Thus, patients with periodontitis are at greater risk for the development and/or exacerbation of diabetes, chronic obstructive pulmonary disease, and cardiovascular diseases, among other conditions. Although it is without question that specific groups of oral bacteria which populate dental plaque play a causative role in the development of periodontitis, it is now thought that once this disease has been triggered, other factors play an equal, and possibly more important, role in its progression, particularly in severe cases or in cases that prove difficult to treat. In this regard, we allude to the host response, specifically the notion that the host, once infected with oral periodontal pathogenic bacteria, will mount a defense response mediated largely through the innate immune system. The most abundant cell type of the innate immune system – polymorphonuclear neutrophils – can, when protecting the host from microbial invasion, mount a response that includes upregulation of proinflammatory cytokines, matrix metalloproteinases, and reactive oxygen species, all of which then contribute to the tissue damage and loss of teeth commonly associated with periodontitis. Of the mechanisms referred to here, we suggest that upregulation of reactive oxygen species might play one of the most important roles in the establishment and progression of periodontitis (as well as in other diseases of inflammation) through the development of oxidative stress. In this overview, we discuss both innate and epigenetic factors (eg, diabetes, smoking) that lead to the development of oxidative stress. This oxidative stress then provides an environment conducive to the destructive processes observed in periodontitis. Therefore, we shall describe some of the fundamental characteristics of oxidative stress and its effects on the periodontium, discuss the diseases and other factors that cause oxidative stress, and, finally, review potentially novel therapeutic approaches for the management (and possibly even the reversal) of periodontitis, which rely on the use of therapies, such as resveratrol and other antioxidants, that provide increased antioxidant activity in the host.

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Section: Nuclear Factor Erythroid 2-related Factor 2-related Pathwaymentioning

confidence: 99%

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Sczepanik

Grossi

Casati

et al. 2020

Periodontology 2000

346

244

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“…Hence, EPM test was used to assess the degree of anxiety in rodent 39 . Enhancement of anxiety in response to CUMS exposure has been earlier reported by investigators who studied the effects of various antidepressants on anxiety 37,51 . In accordance with previous reports, rats exposed to CUMS showed enhanced anxiety and they spent a shorter time on open arms and longer time on the closed arms of the EPM when compared to control group of rats.…”

Section: Discussionmentioning

confidence: 54%

Centella asiatica prevents chronic unpredictable mild stress-induced behavioral changes in rats

et al. 2019

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Background: Depression is a psychological disorder which is associated with mood swings and cognitive deficits, and is ranked third among the leading causes of global health care burden. Chronic unpredictable mild stress (CUMS) has been shown to induce depression-like behaviors in rodents, which exhibit similarities to the human form of depression. Centella asiatica (CA) is an ancient medicinal plant which has neuroprotective potential. This work aimed to assess the protective role of CA on CUMS-induced rats. Methods: Thirty six rats randomly divided into six groups were used for the evaluation. The groups were as follows: 1, Unstressed + normal saline (control); 2, CUMS + normal saline (model); 3, CUMS + fluoxetine (10 mg/kg) standard antidepressant; 4-6, CUMS + CA (200, 400 & 800 mg/kg). Nine different stressors (S) (S1: 24-h food deprivation, S2: 24- h water deprivation, S3: 5-min cold swimming (at 5◦C), S4: 12-h change of cage mate, S5: 1-min tail pinch (1 cm from the tip of the tail), S6: 12-h cage tilt (at 45◦), S7: 12-h overcrowding of cage, S8: 12-h wet bedding with 200 mL of water, and S9: 4-h physical restraint) were administered to the stressed groups with at least 2 stressors per day. The treatments lasted for 8 weeks, and the rats were evaluated through open field test (OFT) and elevated plus maze (EPM) for anxiety-like behavior, forced swimming test (FST) for depression-like behaviour, and T-maze spontaneous alternation for learning and memory. Furthermore, serum cortisol levels were also evaluated. Results: CUMS-induced rats showed anxiety-like behaviors in OFT and EPM tests, depression-like behavior in FST and cognitive deficits in T-maze test, as well as increased serum cortisol levels. Conversely, administration of CA (at 400 and 800 mg/kg doses) and fluoxetine (at 10 mg/kg dose) prevented the aberrant behavioral changes and also the changes in the serum cortisol levels. No significant differences of behaviors were observed between the groups of rats administered with CA (400 and 800 mg/kg) and those administered with fluoxetine (10 mg/kg), suggesting that the therapeutic potential of CA is comparable to that of fluoxetine. Conclusion: The data obtained showed that CA, at doses of 400 and 800 mg/kg, effectively reversed the anxiety and depression-like behaviors, amnesic behaviors, as well as serum cortisol levels in a CUMS-induced rat model of depression. This suggests that CA is a potential candidate for the development of future anti-depressants.

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“…Further experiments also showed that Chinese herbal medicine can correct the HPA axis dysfunction and inhibit the occurrence of inflammation (Cai et al 2015;Wang et al 2018;Wu et al 2019). In addition, previous studies have shown that an olfactory bulb and olfactory epithelium in CUMS mice may be affected by two pathways: neural and energy metabolism (Abd El-Fattah et al 2018). Along with the performance in behavioural experiments, the mitochondria in CUMS mice appeared serious cavitation and the breakage of cristae.…”

Section: Discussionmentioning

confidence: 86%

Intranasal administration of white tea alleviates the olfactory function deficit induced by chronic unpredictable mild stress

Xie

Zhou

et al. 2020

Pharmaceutical Biology

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Resveratrol and dimethyl fumarate ameliorate depression-like behaviour in a rat model of chronic unpredictable mild stress

Cited by 62 publications

References 67 publications

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way

Centella asiatica prevents chronic unpredictable mild stress-induced behavioral changes in rats

Intranasal administration of white tea alleviates the olfactory function deficit induced by chronic unpredictable mild stress

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