Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

Kasiotis, Konstantinos M.; Pratsinis, Harris; Kletsas, Dimitris; Haroutounian, Serkos A.

doi:10.1016/j.fct.2013.03.038

Cited by 171 publications

(102 citation statements)

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“…Furthermore, plant polyphenols are increasingly being associated with putative bioactivities offering protection against several cardiovascular (Goszcz et al 2015) and neurological diseases (Figueira et al 2017). The hydroxystilbenes are a group of polyphenols with a C 6 -C 2 -C 6 skeleton with two or more hydroxyl groups, where a central carbon-carbon double bond is conjugated with two phenolic moieties (Quideau et al 2011;Kasiotis et al 2013). The most well-known representative of this group is resveratrol (trans-3,5,4 0 -hydroxystilbene; Fig.…”

Section: Polyphenols As a Source Of Bioactive Moleculesmentioning

confidence: 99%

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

et al. 2017

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BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production This article is written by the BacHBerry consortium (www. bachberry.eu) and represents the collective effort of all participating institutions. The authors are therefore listed in alphabetical order.Electronic supplementary material The online version of this article

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Section: Polyphenols As a Source Of Bioactive Moleculesmentioning

confidence: 99%

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

et al. 2017

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“…35,36) Stilbenes have been reported to have antibacterial, anti-inflammatory, anti-tumor, antimalarial, and anti-aging effects. [37][38][39][40][41] We previously reported the antioxidant activity of stilbenes isolated from this herb and their inhibitory effects on nitric oxide production from macrophages stimulated by a lipopolysaccharide (LPS). 35,36) In addition, the effects of the principal stilbene constituents on antigen-induced histamine release from rat peritoneal mast cells, 48-h homologous PCA in rats (type I allergic model), and sheep blood cell-induced delayed-type hypersensitivity in mice (type IV allergic model) were also reported.…”

Section: Stilbenesmentioning

confidence: 99%

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

2016

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Mast cells and basophils play important roles in both immediate-and late-phase reactions of type 1 allergy. Histamine, which is released from mast cells and basophils stimulated by an antigen or degranulation inducers, is usually determined as a degranulation marker in experiments on immediate allergic reactions in vitro. β-Hexosaminidase is also stored in secretory granules of the cells and is released concomitantly with histamine when the cells are immunologically activated, and recently this enzyme activity in the medium has been used as a marker of the degranulation. In this paper, we review our studies on the search for degranulation inhibitors, such as flavonoids, stilbenes, and curcuminoids, from medicinal plants using rat basophilic leukemia (RBL-2H3) cells.

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“…First-strand cDNAs were synthesized from each sample by using 50 pmol of poly(T) [12][13][14][15][16][17][18] primer and SuperScript TM III First-Strand Synthesis System according the standard protocol (Invitrogen, USA). For each sample, two separated reverse transcription reactions were pooled.…”

Section: Rna Extraction and Reverse Transcriptionmentioning

confidence: 99%

Cloning, Expression Pattern Analysis and Subcellular Localization of Resveratrol Synthase Gene in Peanut (<i>Arachis hypogaea</i> L.)

Zhu¹,

Han²,

Liu³

et al. 2014

AJPS

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Resveratrol synthase (RS) is a key enzyme that plays a critical role in the resveratrol synthesis pathway. In this study, six RS genes were isolated and characterized from peanut variety "Zhenzhu Hong" by silico cloning and RT-PCR. Bioinformatics analysis showed that deduced amino acid sequences of the six cloned RS genes were highly conserved with a similarity from 95% to 99% when compared to the RS genes which had been deposited at the GenBank. The results of amino acid sequences analysis showed six RS proteins contained the Chal_Sti_Synt_N and ACP_Syn_III_C domains and can be classified to same family but with different evolutionary distance. Expression pattern analysis by QRT-PCR provided evidence indicating that the mRNA of six RS genes were primarily expressed in the peanut shell at different developmental stages with different expression levels, but only lower levels of them were evident in the peanut kernel. The subcellular localization of RS protein in onion epidermal cell was performed by Agrobacterium tumefaciens-mediated transformation and the green fluorescent was monitored by confocal fluorescence microscopy. The results indicated that, RS1 and RS5 were located in the nucleus and plasma membrane respectively, while the RS2, RS3, RS4 and RS6 were located in both nucleus inner membrane and plasma membrane. The data will provide basic information for elucidating the regulatory mechanisms and enzyme kinetics underlying the RS genes in the resveratrol synthase pathway.

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Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

Cited by 171 publications

References 123 publications

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

Cloning, Expression Pattern Analysis and Subcellular Localization of Resveratrol Synthase Gene in Peanut (<i>Arachis hypogaea</i> L.)

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Resveratrol and related stilbenes: Their anti-aging and anti-angiogenic properties

Cited by 171 publications

References 123 publications

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

BacHBerry: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Degranulation Inhibitors from Medicinal Plants in Antigen-Stimulated Rat Basophilic Leukemia (RBL-2H3) Cells

Cloning, Expression Pattern Analysis and Subcellular Localization of Resveratrol Synthase Gene in Peanut (&lt;i&gt;Arachis hypogaea&lt;/i&gt; L.)

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Cloning, Expression Pattern Analysis and Subcellular Localization of Resveratrol Synthase Gene in Peanut (<i>Arachis hypogaea</i> L.)