Resveratrol and Vascular Function

Li, Huige; Xia, Ning; Hasselwander, Solveig; Daiber, Andreas

doi:10.3390/ijms20092155

Cited by 156 publications

(148 citation statements)

References 135 publications

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“…Other data indicating the cardioprotective nature of resveratrol include the risk of atherogenesis. In preclinical studies, oral administration of resveratrol at 4 mg/kg/day reduced significantly the proliferation of smooth muscle cells, hyperplasia of endothelial vessels as well as the secretion of pro-inflammatory cytokines involved in the atherogenesis process [101]. Notably, another cardiovascular outcome associated with the administration of resveratrol in preclinical studies is the reduction of intimal proliferation index (ratio of intimal to (intimal + medial) area) of 45-50% compared to control animals with a significant reduction of α-actin expression in intima [102].…”

Section: Resveratrol In Cardio-oncologymentioning

confidence: 99%

Resveratrol in Cancer Patients: From Bench to Bedside

Berretta

Bignucolo

Francia

et al. 2020

IJMS

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Resveratrol (3,5, is a natural phytoalexin that accumulates in several vegetables and fruits like nuts, grapes, apples, red fruits, black olives, capers, red rice as well as red wines. Being both an extremely reactive molecule and capable to interact with cytoplasmic and nuclear proteins in human cells, resveratrol has been studied over the years as complementary and alternative medicine (CAM) for the therapy of cancer, metabolic and cardiovascular diseases like myocardial ischemia, myocarditis, cardiac hypertrophy and heart failure. This review will describe the main biological targets, cardiovascular outcomes, physico-chemical and pharmacokinetic properties of resveratrol in preclinical and clinical models implementing its potential use in cancer patients.properties of resveratrol are, however, marked by a pharmacokinetic profile and by an unfavorable oral bioavailability, which requires a thorough analysis. To date, to the best of our knowledge, scientific papers and reviews summarizing multiple characteristics of resveratrol, its pharmacokinetic, pharmacodynamic profiles and potential drug interaction in oncology are lacking in literature. Therefore, this review aimed to describe the potential use of resveratrol in cancer management presenting the main biochemical pathways involved, issues and potential uses in cancer patients. Moreover, the involvement of resveratrol in cardioncology, its potential use for risk reduction of myocardial ischemia, myocarditis, cardiac hypertrophy as well as heart failure are also discussed. To endorse this review, we made a comprehensive search on PubMed, Web of Science and SciFinder. The search terms were "resveratrol" combined with "cardioncology" or "cancer" or "drug-food" or "cardiology" or "pharmacokinetic" or "pharmacodynamic". Physico-Chemical and Pharmacokinetic Properties of ResveratrolResveratrol is a low molecular weight phyto-polyphenol of 228 Da that appears as an off-white powder with lipophilic properties (octanol/water partition coefficient, log Kow = 3.1). Its melting point is between 253 and 255 • C, and its solubility in water is very low (3 mg/100 mL) [8]. The ethylene bridge due to a limited degree of freedom generates two geometric isomers: cis-resveratrol and trans-resveratrol ( Figure 1) [5]. These isoforms co-exist in resveratrol extracts even if a greater biological activity and stability are attributed to trans-resveratrol. Comparing to the geometric isomers, the nearly planar structure of trans-resveratrol is less flexible than the non-planar structure of cis-resveratrol, but it possesses a lower repulsive energy that ensures it, albeit small, higher stability. Isomerization of trans-resveratrol to cis-resveratrol occurs via molecule breakdown when trans-resveratrol is exposed to UV radiation at a wavelength of 254 or 366 nm, to high pH conditions or in plants during fermentation processes [5,9]. In analyzing some physical-chemical aspects of resveratrol, Zupancic et al. showed how trans-resveratrol is rapidly degradable in high-pH solutions. In par...

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Section: Resveratrol In Cardio-oncologymentioning

confidence: 99%

Resveratrol in Cancer Patients: From Bench to Bedside

Berretta

Bignucolo

Francia

et al. 2020

IJMS

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“…These characteristics are reminiscent of the phenotype of arterial thickening in atherosclerotic and hypertensive patients [34]. The beneficial effects of resveratrol in endothelial function have been widely studied and reported in the aspect of enhancing endothelial NO production, reducing endothelial oxidative stress and ET-1 synthesis ( Figure 1) [14,35]. These indicate that resveratrol can target arterial remodelling via enhancing the endothelial NO production.…”

Section: Improvement Of Endothelial Functionmentioning

confidence: 93%

“…Resveratrol is well-studied for its beneficial effects on cardiovascular protection by increasing the production of nitric oxide (NO) in endothelial cells. Resveratrol can upregulate endothelial NO synthase (eNOS) expression, stimulate eNOS activity, and prevent eNOS uncoupling [14]. In addition, resveratrol modulates the function of immune cells, inhibits immune cell infiltration, and improves PVAT function [15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Arterial remodelling is an important feature of the progression of hypertension [6,17]. Resveratrol has been studied for its effect on modulating gut microbiota and arterial remodelling, respectively [14,18]. Currently, accumulating evidence has suggested that gut microbiota may participate in the development of metabolic and cardiovascular diseases by interacting with the immune system and inflammatory processes [19].…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

Man

Xia

2020

Nutrients

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Arterial remodelling refers to the alteration in the structure of blood vessel that contributes to the progression of hypertension and other cardiovascular complications. Arterial remodelling is orchestrated by the crosstalk between the endothelium and vascular smooth muscle cells (VSMC). Vascular inflammation participates in arterial remodelling. Resveratrol is a natural polyphenol that possesses anti-oxidant and anti-inflammatory properties and has beneficial effects in both the endothelium and VSMC. Resveratrol has been studied for the protective effects in arterial remodelling and gut microbiota, respectively. Gut microbiota plays a critical role in the immune system and inflammatory processes. Gut microbiota may also regulate vascular remodelling in cardiovascular complications via affecting endothelium function and VSMC proliferation. Currently, there is new evidence showing that gut microbiota regulate the proliferation of VSMC and the formation of neointimal hyperplasia in response to injury. The change in population of the gut microbiota, as well as their metabolites (e.g., short-chain fatty acids) could critically contribute to VSMC proliferation, cell cycle progression, and migration. Recent studies have provided strong evidence that correlate the effects of resveratrol in arterial remodelling and gut microbiota. This review aims to summarize recent findings on the resveratrol effects on cardiovascular complications focusing on arterial remodelling and discuss the possible interactions of resveratrol and the gut microbiota that modulate arterial remodelling.

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“…Resveratrol, one of the most important naturally active polyphenols, has some proven effects, such as antioxidant, anti-inflammatory, and antitumour [26,27]. Resveratrol not only reduces oxidative stress and inflammatory response but also modulates immune responses [28,29]. ese effects make it possible for the treatment of PAA.…”

Section: Resveratrolmentioning

confidence: 99%

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

Liu

Feng

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Adhesion is a frequent complication after abdominal surgery. Although various methods have been applied to prevent and treat postoperative abdominal adhesion (PAA), few modern drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far. There is an imperative to develop some new strategies for the treatment of PAA. Traditional Chinese medicine (TCM) has been widely practiced for thousands of years and played an indispensable role in the prevention and treatment of diseases. Modern medicine researchers have accepted the therapeutic effects of many active components derived from Chinese medicinal herbs. The review stresses the most commonly used TCM treatment, including Chinese medicinal herbals and monomers, TCM formulas, and acupuncture treatment.

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Resveratrol and Vascular Function

Cited by 156 publications

References 135 publications

Resveratrol in Cancer Patients: From Bench to Bedside

Resveratrol in Cancer Patients: From Bench to Bedside

Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

Application of Traditional Chinese Medicines in Postoperative Abdominal Adhesion

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