Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors

Dong, Wenfang; Li, Nanlin; Gao, Dakuan; Zhen, Hai‐Ning; Zhang, Xiang; Li, FanFan

doi:10.1016/j.jvs.2008.04.007

Cited by 99 publications

(76 citation statements)

References 23 publications

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“…Findings from several studies have demonstrated that performance of dogs in cognitive tests (including those that examine spatial memory) can be improved by various substances (including antioxidants, mitochondrial cofactors and a pharmaceutical with alpha-1 adrenergic agonist action) and by behavioural enrichment [21][22][23][24][25]. Oral administration of resveratrol has been used with success in previous studies of cognitive function in animals [3,5,9,10]. There are very few studies on the bioavailability of resveratrol in dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol, a plant-derived phytoestrogen, may minimise the deterioration in cognitive function associated with physical and chemical damage to the brain [1][2][3][4][5][6][7]. In rats and mice, resveratrol has been found to minimise the adverse brain and cognitive changes induced by neurologically damaging events such as streptozotocin-induced diabetes [1]; percussive cerebral trauma [2]; focal cerebral ischemia (stroke) [3]; oxidative stress caused by intracerebroventricular injection of streptozotocin [4] or cochinine [5]; and neurotoxic substances used to mimic Huntington's disease [6] and Parkinson's disease [7].…”

Section: Introductionmentioning

confidence: 99%

“…In rats and mice, resveratrol has been found to minimise the adverse brain and cognitive changes induced by neurologically damaging events such as streptozotocin-induced diabetes [1]; percussive cerebral trauma [2]; focal cerebral ischemia (stroke) [3]; oxidative stress caused by intracerebroventricular injection of streptozotocin [4] or cochinine [5]; and neurotoxic substances used to mimic Huntington's disease [6] and Parkinson's disease [7]. Resveratrol has been shown to decrease lipid peroxidation and up-regulate antioxidant enzymes in the brains of healthy male rats [8].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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Abstract:Resveratrol supplements are marketed on the premise they enhance cognitive function. We explored effects of resveratrol supplementation on cognitive function, in the absence of pathology, by assessing effects of resveratrol on the performance of young, healthy, recently gonadectomised dogs in an eight-arm radial maze. Effects of gonadectomy on cognition were also assessed. Performances of untreated intact dogs, resveratrol-treated gonadectomised dogs (60mg/day of resveratrol orally) and placebo-treated gonadectomised dogs were compared in three phases. Dogs received the placebo or resveratrol for two to four weeks before testing began. In phase one, untreated intact (n = 16), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) were allowed to choose all maze arms they entered. In phase two, untreated intact (n = 15), resveratrol-treated gonadectomised (n = 6) and placebo-treated gonadectomised dogs (n = 5) entered four predetermined arms and then made four free choices from all eight arms. In phase three, a subset of dogs previously tested as untreated intact dogs in phases one and two were tested. In phase three, placebotreated gonadectomised (n = 6) and resveratrol-treated gonadectomised dogs (n = 6) entered seven predetermined arms and then had free choice between a previously opened arm and the unopened arm. Performance in the maze did not differ significantly between gonadectomised dogs receiving the placebo and gonadectomised dogs receiving resveratrol or between untreated intact dogs and gonadectomised dogs receiving the placebo. We conclude that resveratrol treatment does not improve (and gonadectomy does not impair) the aspects of cognitive function that were tested by the radial arm maze trials in young, healthy dogs receiving extensive handling and environmental/behavioural enrichment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Story¹

2012

TONUTRJ

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“…In the heart, resveratrol increased levels of vascular endothelial growth factor (VEGF) and its receptor FLK-1, leading to enhanced angiogenesis and reduced myocardial infarction (Fukuda et al, 2006). This protection has also been shown in the brain where administration of resveratrol elevated proangiogenic factors such as matrix metalloproteinase-2 and VEGF levels providing neuroprotection after focal ischemia in the delayed injury phase (Dong et al, 2008).…”

Section: Resveratrol-activated Pathways Protect Against Ischemic Injurymentioning

confidence: 93%

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

Morris

Lin

Thompson

et al. 2011

J Cereb Blood Flow Metab

120

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Caloric restriction (CR), resveratrol, and ischemic preconditioning (IPC) have been shown to promote protection against ischemic injury in the heart and brain, as well as in other tissues. The activity of sirtuins, which are enzymes that modulate diverse biologic processes, seems to be vital in the ability of these therapeutic modalities to prevent against cellular dysfunction and death. The protective mechanisms of the yeast Sir2 and the mammalian homolog sirtuin 1 have been extensively studied, but the involvement of other sirtuins in ischemic protection is not yet clear. We examine the roles of mammalian sirtuins in modulating protective pathways against oxidative stress, energy depletion, excitotoxicity, inflammation, DNA damage, and apoptosis. Although many of these sirtuins have not been directly implicated in ischemic protection, they may have unique roles in enhancing function and preventing against stress-mediated cellular damage and death. This review will include in-depth analyses of the roles of CR, resveratrol, and IPC in activating sirtuins and in mediating protection against ischemic damage in the heart and brain.

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“…Resveratrol attenuates ischemic brain damage by increasing the expression of matrix metalloproteinase-2 and vascular endothelial growth factor 6) and exerting anti-oxidative, anti-inflammatory and anti-apoptotic effects 7,8) .…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

Chiba

Yokotani

Suzuki

et al. 2015

JAT

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Aim:Resveratrol has been shown to mimic the beneficial effects of dietary restriction (DR). We previously reported that DR delays stroke onset and extends the lifespan in Stroke-Prone Spontaneously Hypertensive rats (SHRSP). Therefore, we examined whether resveratrol mimics DR and delays stroke onset in SHRSP. Methods: Cerebrovascular endothelial cells (CVECs) from SHRSP were treated with resveratrol, and the inflammatory gene expression levels and NF B protein levels were measured. In order to address the effects of resveratrol in vivo, SHRSP (male, 10 weeks of age) were fed an experimental diet containing several doses of resveratrol (0 -0.05% (w/w)), after which we measured the plasma cytokine levels and examined the stroke onset and lifespan.

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Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors

Abstract: Resveratrol administration by gavage provided an important neuroprotective effect on focal cerebral ischemic injury in the delayed phase. The elevated MMP-2 and VEGF levels might be important in the neuroprotective effect of resveratrol administration by inducing angiogenesis.

Cited by 99 publications

References 23 publications

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Effect of Resveratrol Supplementation on the Performance of Dogs in an Eight-Arm Radial Maze

Pathways for Ischemic Cytoprotection: Role of Sirtuins in Caloric Restriction, Resveratrol, and Ischemic Preconditioning

Resveratrol Partially Suppresses Inflammatory Events but Does not Affect Stroke Onset in Stroke-Prone Spontaneously Hypertensive Rats

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