Resveratrol: Change of SIRT 1 and AMPK signaling pattern during the aging process

Caldeira, Camila Amaro; Santos, Milena Almeida; Araújo, Glaucy Rodrigues de; Lara, Raquel Cunha; Franco, Filipe Nogueira; Chaves, Mı́riam Martins

doi:10.1016/j.exger.2021.111226

Cited by 24 publications

(10 citation statements)

References 45 publications

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“…In our analysis, this double-negative theory may account in part for the age-associated decline in protein synthesis as well as increased proteolysis via autophagy. Another potential explanation is attributed to redox resistance within AMPK, supported by a recent study by Caldeira et al [116]. In this study, AMPK from peripheral blood mononuclear cells of middle-aged individuals was able to be activated in response to an oxidative challenge and reduce oxidative stress.…”

Section: Ampk Signalingsupporting

confidence: 63%

Redox Signaling and Sarcopenia: Searching for the Primary Suspect

Foreman

Hesse

2021

IJMS

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Sarcopenia, the age-related decline in muscle mass and function, derives from multiple etiological mechanisms. Accumulative research suggests that reactive oxygen species (ROS) generation plays a critical role in the development of this pathophysiological disorder. In this communication, we review the various signaling pathways that control muscle metabolic and functional integrity such as protein turnover, cell death and regeneration, inflammation, organismic damage, and metabolic functions. Although no single pathway can be identified as the most crucial factor that causes sarcopenia, age-associated dysregulation of redox signaling appears to underlie many deteriorations at physiological, subcellular, and molecular levels. Furthermore, discord of mitochondrial homeostasis with aging affects most observed problems and requires our attention. The search for the primary suspect of the fundamental mechanism for sarcopenia will likely take more intense research for the secret of this health hazard to the elderly to be unlocked.

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Section: Ampk Signalingsupporting

confidence: 63%

Redox Signaling and Sarcopenia: Searching for the Primary Suspect

Foreman

Hesse

2021

IJMS

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“…17 Antioxidants inhibit lipid peroxidation, neutralize oxygen radicals and terminate the chain reaction before inducing free radical damage. 18 Although GSPE has exerted various beneficial effects towards its ability to promote the antioxidant defense system, little information is available with regard to its mechanism of anti-aging effects, especially with respect to gut microbiota modulation. Therefore, the alleviation effects of GSPE on aging were evaluated with respect to antioxidant capacity, inflammation, gut microbiota, and NLRP3 inflammasome signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Sheng

Yang

et al. 2022

Food Funct.

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“…As a key factor in the regulation of bioenergy metabolism, AMPK plays a vital role in anti-inflammatory and growth regulation, which are also key to metabolic-related diseases 52 , 53 . AMPK is also related to multiple signaling pathways such as SIRT1, NF-κB, mTOR, and P53 54 . P53 tumor suppressor protein is a multifunctional transcription factor that regulates cell proliferation, cycle and apoptosis.…”

Section: Discussionmentioning

confidence: 99%

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota

Zhao

Liu

Zheng

et al. 2021

Sci Rep

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Aronia melanocarpa is a natural medicinal plant that has a variety of biological activities, its fruit is often used for food and medicine. Aronia melanocarpa polysaccharide (AMP) is the main component of the Aronia melanocarpa fruit. This research evaluated the delay and protection of AMP obtained from Aronia melanocarpa fruit on aging mice by d-Galactose (D-Gal) induction and explored the effect of supplementing AMP on the metabolism of the intestinal flora of aging mice. The aging model was established by intraperitoneal injection of D-Gal (200 mg/kg to 1000 mg/kg) once per 3 days for 12 weeks. AMP (100 and 200 mg/kg) was given daily by oral gavage after 6 weeks of D-Gal-induced. The results showed that AMP treatment significantly improved the spatial learning and memory impairment of aging mice determined by the eight-arm maze test. H&E staining showed that AMP significantly reversed brain tissue pathological damage and structural disorders. AMP alleviated inflammation and oxidative stress injury in aging brain tissue by regulating the AMPK/SIRT1/NF-κB and Nrf2/HO-1 signaling pathways. Particularly, AMP reduced brain cell apoptosis and neurological deficits by activating the PI3K/AKT/mTOR signaling pathway and its downstream apoptotic protein family. Importantly, 16S rDNA analysis indicated the AMP treatment significantly retarded the aging process by improving the composition of intestinal flora and abundance of beneficial bacteria. In summary, this study found that AMP delayed brain aging in mice by inhibiting inflammation and regulating intestinal microbes, which providing the possibility for the amelioration and treatment of aging and related metabolic diseases.

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Resveratrol: Change of SIRT 1 and AMPK signaling pattern during the aging process

Cited by 24 publications

References 45 publications

Redox Signaling and Sarcopenia: Searching for the Primary Suspect

Redox Signaling and Sarcopenia: Searching for the Primary Suspect

Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a d-galactose-induced aging mouse model by modulating the gut microbiota

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota

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