Resveratrol enhances the effects of ALA-PDT on skin squamous cells A431 through p38/ MAPK signaling pathway

Zhang, Xin; Liu, Xia; Kang, Shuxia; Liu, Caiyun; Hao, Yuqin

doi:10.3233/cbm-170495

Cited by 22 publications

(16 citation statements)

References 26 publications

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“…Moreover, resveratrol dose-dependently increased both apoptotic and necrotic cells after 24 hr treatment of two melanoma cell lines [108]. In addition, resveratrol also inhibited the growth of squamous cell carcinoma cells (A431 cell line) [81]. Resveratrolinduced apoptosis and inhibition of cell proliferation were also observed in human head and neck squamous cell carcinoma cell lines, e.g., FaDu, Cal27, and Det562 cell lines [111].…”

Section: Anticancermentioning

confidence: 89%

“…Both in vitro and in vivo studies have shown that resveratrol also inhibits proliferation, while stimulating apoptosis of cancer cells via several mechanisms. First, resveratrol induces apoptosis and phosphorylation of MAPK/ERK and MAPK/p38 in addition to increasing expression levels of caspase 3 and p53, while conversely, inhibition of p38 abolished its apoptotic effects [81,188]. It appears that resveratrol-induced phosphorylation of p53 and apoptosis is mediated by c-Jun NH2-terminal kinases because knockdown of c-Jun NH2-terminal kinase genes prevented both phosphorylation of p53 and apoptosis induced by resveratrol [189].…”

Section: Anticancer Activitymentioning

confidence: 99%

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Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Protective role of the skin is against external insults and maintenance of electrolyte homeostasis of the body. Cutaneous dysfunction can account for the development of both cutaneous and systemic disorders. Thus, improvements in cutaneous functions can benefit a number of extracutaneous and cutaneous functions. Resveratrol, a natural ingredient, displays multiple benefits for various systems/organs, including the skin. The benefits of resveratrol for cutaneous functions include stimulation of keratinocyte differentiation and antimicrobial peptide expression, inhibition of keratinocyte proliferation and cutaneous inflammation, UV protection, anticancer, antiaging, and inhibition of melanogenesis. The mechanisms of action of resveratrol include activation of sirtuin 1 and nuclear factor erythroid 2-related factor 2, and inhibition of mitogen-activated protein kinase signaling. Evidence suggests that topical resveratrol could be a valuable alternative not only for daily skin care, but also for the prevention and treatment of various cutaneous disorders. This review summarizes the benefits of resveratrol for cutaneous functions.

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Section: Anticancermentioning

confidence: 89%

Section: Anticancer Activitymentioning

confidence: 99%

Role of Resveratrol in Regulating Cutaneous Functions

Wen

Zhang

Yang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…Unlike our results, other studies revealed that RES associated to ALA-PDT enhanced the effect of PDT on A431 cell proliferation and apoptosis. Moreover, the expressions of p-ERK, p-p53, p53 and caspase-3 increased after the combined therapy, suggesting an effect mediated by p38/MAPK pathway [55]. The extracts of Lumnitzera racemosa, Albizia procera and Cananga odorata photoactivated were cytotoxic against MCF-7 cells compared to the effects on non-tumor cells and induced apoptosis [56].…”

Section: Discussionmentioning

confidence: 96%

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

Laszló

Popescu

et al. 2022

Medicine and Pharmacy Reports

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Background and aim. Photodynamic therapy, PDT, is a promising option among the local treatments with oncolytic potential. Although the basic principle is simple, its intricate mechanisms allow for a broad range of optimization methods. The purpose of this study was to assess the effects of Resveratrol and Curcumin as adjuvants of PDT on experimental tumors. Methods. Sixty-six Wistar male rats were divided into 11 groups: control, Curcumin (CUR), Resveratrol (RES) alone or followed by irradiation (IR) (CUR+IR and RES+IR, respectively), 5,10,15,20-tetra-sulphonato-phenyl-porphyrin (TSPP), TSPP+IR (PDT), and CUR or RES administered prior to or after PDT (CUR+TSPP+IR, RES+TSPP+IR, TSPP+IR+CUR, TSPP+IR+RES). Results. Both CUR and RES significantly decreased lipid peroxidation, while RES also showed an increase in glutathione (GSH) levels, especially when it was administered before PDT (p<0.01). Both antioxidants decreased cyclooxygenase (COX)2 expression, to a minimum when they administered prior to PDT (p<0.001 and p<0.01) while nitric oxide synthase (NOS)2 expression diminished in the combined regimen, particularly in RES associated with PDT. CUR and RES induced similar changes in terms of cell death, but CUR seemed to be more efficient on tumor necrosis and showed a higher apoptotic index when was administered after PDT (p<0.001). Conclusion. Both RES and CUR in association with PDT decreased oxidative stress, diminished the COX2 and NOS2 expressions and increased cell death by positively influencing the necrotic rate and apoptotic index, particularly when CUR was administered after PDT. The results show that CUR is a promising class to study in PDT optimization and further invites to exploit its promises.

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“…The HacaT non-tumorigenic keratinocyte cell line was used as a control and was acquired from the Experimental Zooprophylactic Institute of Lombardia and Emilia Romagna (Brescia, Italy). The HacaT cell line can be used as non-tumor control of the A431 cells (56)(57)(58)(59)(60) and it is considered a reliable model for skin diseases and for in vitro carcinogenesis of human skin keratinocytes (61,62). The HacaT and A431 cell lines were cultured under the same culture conditions to prevent differences in phototoxicity related to different growth mediums.…”

Section: Methodsmentioning

confidence: 99%

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

et al. 2021

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New approaches are being studied for the treatment of skin cancer. It has been reported that light combined with cisplatinum may be effective against skin cancer. In the present study, the effects of specific light radiations and cisplatinum on A431 cutaneous squamous cell carcinoma (cScc) and HacaT non-tumorigenic cell lines were investigated. Both cell lines were exposed to blue and red light sources for 3 days prior to cisplatinum treatment. Viability, apoptosis, cell cycle progression and apoptotic-related protein expression levels were investigated. The present results highlighted that combined treatment with blue light and cisplatinum was more effective in reducing cell viability compared with single treatments. Specifically, an increase in the apoptotic rate was observed when the cells were treated with blue light and cisplatinum, as compared to treatment with blue light or cisplatinum alone. combined treatment with blue light and cisplatinum also caused cell cycle arrest at the S phase. Treatment with cisplatinum following light exposure induced the expression of apoptotic proteins in the A431 and HacaT cell lines, which tended to follow different apoptotic mechanisms. On the whole, these data indicate that blue light combined with cisplatinum may be a promising treatment for cScc.

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Resveratrol enhances the effects of ALA-PDT on skin squamous cells A431 through p38/ MAPK signaling pathway

Abstract: Our study demonstrated that Res could enhance the effect of ALA-PDT against skin cancer cells through p38/ MAPK pathway.

Cited by 22 publications

References 26 publications

Role of Resveratrol in Regulating Cutaneous Functions

Role of Resveratrol in Regulating Cutaneous Functions

The comparative effects of Resveratrol and Curcumin in combination with photodynamic therapy

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

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