Resveratrol extracted from Chinese herbal medicines: A novel therapeutic strategy for lung diseases

Abstract

Lung diseases and their related complications represent a critical source of morbidity and mortality globally and have become a research focus in recent years. There are plenty of hazards that threaten the health of lung by exposure to external environmental stimuli, such as dust, cigarette smoke, PM2.5, air pollution and pathogen infection. These risks lead to the impairment of lung function and subsequent lung diseases including pneumonia, chronic obstructive pulmonary disease (COPD), asthma and idiopathic pulmonary fibrosis (IPF). Compared with antibiotics and corticosteroids therapies, traditional Chinese medicine prescriptions are more effective with fewer side effects. A considerable variety of bioactive ingredients have been extracted and identified from Chinese herbal medicines and are used for the treatment of different lung diseases, including resveratrol. Increasing studies have reported promising therapeutic effects of resveratrol against lung diseases by inhibiting oxidative stress, inflammation, aging, fibrosis and cancer both in vitro and in vivo . In this review, the recent progress in the studies of lung-protective effects and underlying mechanisms of resveratrol and also highlight the potency of resveratrol and traditional Chinese prescriptions containing resveratrol as promising therapeutic options were summarized for the treatment of lung and respiratory diseases.

Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

“…Resveratrol (3,5,4-trihydroxystilbene) is a nonflavonoid polyphenolic compound found in multiple plant species, including grapes and peanuts. Resveratrol has been reported to exert a vast number of health benefits, such as antioxidant, antiinflammatory, antifibrotic, antiviral, and anticancer activities, through many different mechanisms of action (Tomé-Carneiro et al, 2013;Ma and Li, 2020). Several studies have highlighted the therapeutic effects of resveratrol against lung diseases mainly by decreasing oxidant stress and inhibiting inflammatory responses (Conte et al, 2015;Ma and Li, 2020).…”

“…Resveratrol has been reported to exert a vast number of health benefits, such as antioxidant, antiinflammatory, antifibrotic, antiviral, and anticancer activities, through many different mechanisms of action (Tomé-Carneiro et al, 2013;Ma and Li, 2020). Several studies have highlighted the therapeutic effects of resveratrol against lung diseases mainly by decreasing oxidant stress and inhibiting inflammatory responses (Conte et al, 2015;Ma and Li, 2020). One of the protective mechanisms of resveratrol par excellence is the activation of the Nrf2 pathway and, therefore, the induction of the expression of several antioxidants enzymes and the regulation of GSH homeostasis (Zhu et al, 2017) (Figure 4).…”

Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach

“…We have previously shown the neuroprotective potential of naringenin through modulation of inflammatory mediators (NF-κB, TNF-α, IL-1β, etc) and microglia activation in the CNS ( Nouri et al, 2019 ), thereby it could mitigate the neuronal signs of COVID-19 mediated by the inflammatory mediators. As another phenolic compound, resveratrol has shown promising beneficial effects against COVID-19, through the activation of ERK1/2 and SIR1 signaling pathways related to survival, DNA protection ( Levy et al, 2020 ; Ma and Li, 2020 ), and anti-neuroinflammatory responses ( Bastianetto et al, 2015 ). It also inhibits neuroapoptosis by reducing FGF-2 and suppressing NF-κB ( Xu et al, 2018 ).…”

Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?

“…The positive effects in cancer are related to by the inhibition of oxidative stress, inflammation, aging, and fibrosis [ 76 , 77 ]. In lung cancer, and more widely, in lung diseases resveratrol represents a promising natural compound to be used in association with other drugs [ 78 ]. Although it is clear that resveratrol has shown excellent anti-cancer properties, most of the studies were performed in vitro or in pre-clinical models.…”