Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults

Pollack, Rena; Barzilai, Nir; Anghel, Valentin; Kulkarni, Ameya; Golden, Aaron; O'Broin, Pilib; Sinclair, David A.; Bonkowski, Michael S.; Coleville, Alexander J; Powell, Danielle; Kim, Sharon; Moaddel, Ruin; Stein, Daniel T.; Zhang, Kehao; Hawkins, Meredith; Crandall, Jill P.

doi:10.1093/gerona/glx041

Cited by 87 publications

(60 citation statements)

References 48 publications

(55 reference statements)

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“…Likewise, in animal studies in vivo, resveratrol induced mitochondrial biogenesis in cardiomyocytes to attenuate angiotensin II‐induced cardiac remodelling (Biala et al, ). More importantly, resveratrol treatment is associated with improved vascular function and increased mitochondrial number in glucose‐intolerant, elderly patients (Pollack et al, ). An increased mitochondrial biogenesis can ameliorate the impaired energy homeostasis of aging heart and vasculature.…”

Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 99%

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Cheng

Luo

Lau

et al. 2019

British J Pharmacology

112

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Resveratrol (trans‐3,4′,5‐trihydroxystilbene) belongs to the family of natural phytoalexins. Resveratrol first came to our attention in 1992, following reports of the cardioprotective effects of red wine. Thereafter, resveratrol was shown to exert antioxidant, anti‐inflammatory, anti‐proliferative, and angio‐regulatory effects against atherosclerosis, ischaemia, and cardiomyopathy. This article critically reviews the current findings on the molecular basis of resveratrol‐mediated cardiovascular benefits, summarizing the broad effects of resveratrol on longevity regulation, energy metabolism, stress resistance, exercise mimetics, circadian clock, and microbiota composition. In addition, this article also provides an update, both preclinically and clinically, on resveratrol‐induced cardiovascular protection and discusses the adverse and inconsistent effects of resveratrol reported in both preclinical and clinical studies. Although resveratrol has been claimed as a master anti‐aging agent against several age‐associated diseases, further detailed mechanistic investigation is still required to thoroughly unravel the therapeutic value of resveratrol against cardiovascular diseases at different stages of disease development. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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Section: Molecular Basis Of Resveratrol Actionmentioning

confidence: 99%

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Cheng

Luo

Lau

et al. 2019

British J Pharmacology

112

View full text Add to dashboard Cite

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“…Therefore, resveratrol has been studied to restore these molecular pathways and redox equilibrium in senescent cells. Although several studies in cell culture or laboratory animals' models show positive effects of resveratrol on antioxidant defense, inflammation, and lifespan [4,53], human studies are not so consistent. Resveratrol supplementation for 6 weeks in older adults increases the expression of several mitochondrial genes, however, it is noteworthy that mitochondrial function or redox state was not directly addressed in this study [53].…”

Section: Nutritionmentioning

confidence: 99%

“…Although several studies in cell culture or laboratory animals' models show positive effects of resveratrol on antioxidant defense, inflammation, and lifespan [4,53], human studies are not so consistent. Resveratrol supplementation for 6 weeks in older adults increases the expression of several mitochondrial genes, however, it is noteworthy that mitochondrial function or redox state was not directly addressed in this study [53]. In addition, resveratrol supplementation seems to blunt exercise training-induced adaptations, such as improvements on VO 2max and angiogenesis, in aged humans [17].…”

Section: Nutritionmentioning

confidence: 99%

Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool

Brunetta

Holwerda

Loon

et al. 2019

J. of SCI. IN SPORT AND EXERCISE

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Sarcopenia, which is characterized by reduction in muscle mass and strength, contributes to several age-related conditions, including insulin resistance and frailty. Despite the importance of maintaining muscle mass for healthy aging, the mechanisms contributing to sarcopenia are not fully elucidated. Nevertheless, mitochondria appear to play a key role in the underlying condition, and importantly, respond robustly to exercise interventions. Mitochondria are intracellular organelles largely attributed to maintaining ATP concentrations, however, the importance of this organelle in overall cellular homeostasis has been expanded in the last decades to include redox signaling, calcium homeostasis, inflammation, and apoptosis. Several lines of evidence suggest that mitochondrial bioenergetics are altered in aged skeletal muscle, resulting in an increase in reactive oxygen species (ROS) production, while conversely genetic/pharmacological approaches that attenuate mitochondrial ROS promote healthy aging and maintenance of muscle mass. These observations suggest that increased free radicals are one of the bases of the aging process and related sarcopenia. Here, we reviewed the current knowledge regarding mitochondrial function and redox balance in aged human skeletal muscle, highlighting the implications of redox unbalance on skeletal muscle mass maintenance and muscle health. Additionally, we describe the benefits of exercise and nutrition interventions in the context of improving mitochondrial bioenergetics and functional outcomes regarding skeletal muscle mass and function.

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“…Likewise, in the absence of a glucose-lowering effect, insulin levels were reduced by 5% in T2DM patients with periodontal disease following 4 weeks of 480 mg/day resveratrol [ 14 ]. However, a recent meta-analysis by Zhu et al of nine studies performed in T2DM was only able to confirm a beneficial effect of resveratrol for reducing HOMA-IR [ 15 ], while other clinical studies examining the influence of resveratrol on diabetes biomarkers (i.e., insulin sensitivity and glucose tolerance) have been inconclusive, making the interpretation of results difficult [ 16 , 17 ]. It was argued that there may be an optimal dose range for metabolic effects since Brasyno et al and Goh et al did not find changes in insulin concentrations in T2DM patients receiving resveratrol doses of 10 mg/day and 3000 mg/day respectively [ 18 , 19 ].…”

Section: Does Resveratrol Improve Insulin Sensitivity? Evidence Frmentioning

confidence: 99%

Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation

Wong

Howe

2018

Nutrients

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Pre-clinical data and human trials indicate that resveratrol supplementation may help to counteract diabetes. Several mechanisms of action have been proposed to explain its metabolic benefits, including activation of sirtuins and estrogen receptors (ER) to promote glucose transporter type-4 (GLUT4) translocation and increase glucose uptake. Resveratrol can also enhance vasodilator function, yet the possibility that this action might help to alleviate insulin resistance in type-2 diabetes mellitus has received little attention. In this brief review we propose that, by restoring impaired endothelium-dependent vasodilatation in insulin resistant individuals resveratrol increases blood perfusion of skeletal muscle, thereby facilitating glucose delivery and utilization with resultant improvement of insulin sensitivity. Thus, circulatory improvements by vasoactive nutrients such as resveratrol may play a role in preventing or alleviating insulin resistance.

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Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults

Cited by 87 publications

References 48 publications

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Pharmacological basis and new insights of resveratrol action in the cardiovascular system

Mitochondrial ROS and Aging: Understanding Exercise as a Preventive Tool

Resveratrol Counteracts Insulin Resistance—Potential Role of the Circulation

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