Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells

Resveratrol analogue HS-1793 induces the modulation of tumor-derived T cells

“…However, considerable uncertainty remains in regards to the effect of HS-1793 on tumor immunity. Meanwhile, it was reported that immunomodulatory and anticancer properties can conceivably be controlled by the suppression of the Treg cell population, which makes the peritumoral microenvironment unfavorable to the tumor and eventually results in growth inhibition of tumor cells (19). The present study was undertaken to examine whether HS-1793 exhibits a direct effect on immune responses by enhancing lymphocyte proliferation or an immunomodulating effect by inducing changes in the Treg cell population in tumor-bearing mice.…”

Resveratrol analog, HS-1793 enhance anti-tumor immunity by reducing the CD4+CD25 + regulatory T cells in FM3A tumor bearing mice

“…One of these agents is resveratrol which is gaining much attention. Resveratrol has been shown to inhibit cellular events associated with tumor initiation, promotion and progression in various types of solid tumors and to enhance the immune response in mice by promoting the production of Th1 cytokines, enhancing lymphocyte proliferation and suppressing Treg cell population [7][8][9][10]. However, its biological activities require high doses and are limited by photosensitivity and metabolic instability.…”

Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D‐dependent pathways

“…In contrast, low doses of resveratrol has been shown to enhance immune responses in mice by promoting the production of Th1 cytokines such as IL-12 and IFN-g, and by enhancing lymphocyte proliferation and IL-2 production (Feng et al, 2002). In human immune cells, resveratrol was shown to enhance cytokine production by both CD4þ and CD8þ T cells (Falchetti et al, 2001) and to enhance IFN-g production by CD8þ T cells both ex vivo and in vivo, leading to immune activation (Yang et al, 2008).…”