Resveratrol is able to increase bone mass and biomechanical properties on aged bone

Fernandez-Tresguerres, F Gonzalez; Sirvent, Audrey; Moreno, IB Herreros; Alcaide, LM Saez; Pintor, R Lopez; Vallejo, Gonzalo Hernández

doi:10.4317/medoral.17644066

Cited by 3 publications

(7 citation statements)

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“…Moreover, MSG is shown to have side effects on different body systems; studies reported that diets that contained food additives affected brain neurotransmission, psychological status, behavior, and memory, especially in children (Zeisel 1986 , Löwik 1996 , Pollitt et al 1996 , Umukoro et al 2015 , Zanfirescu et al 2019 , Akataobi 2020 ). Moreover, it is believed that MSG can induce obesity; pregnant women who consumed MSG during the gestational period could have a connection with future obesity of the newborn, who suffered from hypothalamic lesions while being in the uterus (Fernández-Tresguerres 2006 , Hermanussen et al 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Shosha

Ebaid

Toraih

et al. 2023

Environ Sci Pollut Res

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Monosodium glutamate (MSG) is a widespread flavor enhancer and stabilizer in manufactured or packaged foods that possess myriad adverse effects. This study aimed to evaluate the effect of MSG on placental progesterone receptors and fetal development. Thirty pregnant Wistar Albino rats were divided into three groups (ten/each). The control group (G1) gavaged distilled water only, low-dose treated group (G2) gavaged 3 g/kg MSG, and high-dose treated group (G3) gavaged 6 g/kg MSG from 1st to 18th days of gestation, and all pregnant rats were sacrificed on the 19th day of gestation. The effect of MSG on fetal weights, crown vertebral length (CVL), placental weight, placental ghrelin expression, and fetal skeleton examination were estimated. MSG induced a significant decrease in fetal weights, CVL lengths, placental weight, and ghrelin expression in both treatment groups compared to the control group. Several parts of the fetal skeleton showed incomplete ossification and delayed chondrification in which high-dose maternally treated fetuses were more affected. Many degenerative changes were detected in both maternal and fetal liver and kidney tissues in MSG-treated groups. Moreover, MSG caused a significant increase in serum ALT, ALP, and creatinine levels in pregnant rats’ blood. Serum progesterone was only elevated in G3 on the 19th day of gestation. This study showed that the administration of MSG during pregnancy adversely influences fetal growth and skeletal development and caused several biochemical and histological changes in the maternal and fetal liver and kidney tissues which assure the toxic and teratogenic effects of MSG.

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Section: Introductionmentioning

confidence: 99%

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Shosha

Ebaid

Toraih

et al. 2023

Environ Sci Pollut Res

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“…Among the proteins involved in bone matrix formation, the most relevant are osteocalcin (OCN), collagen type I (COL-I), and alkaline phosphatase (ALP). Osteocalcin is a protein secreted by osteoblasts as part of the extracellular matrix and is the most abundant of the non-collagenous proteins (Koga et al, 2005;Fernańdez-Tresguerres et al, 2006;Perez-Amodio et al;Hayman, 2008). Collagen type I is an extracellular matrix protein in bone tissue and represents the most important and abundant of the collagen proteins found in bone (Matsubara et al, 2008;Gistelinck et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…Plasma levels of ALP represent a marker of osteoblastic activity (Delmas et al, 2000;Kuo and Chen, 2017). Moreover, there was a direct relationship between the presence of ALP and the correct mineralization of bone tissue in vertebrates (Delmas et al, 2000;Fernańdez-Tresguerres et al, 2006;Kuo and Chen, 2017). Another phosphatase fraction in bone tissue is an acid phosphatase, a marker of tartrate-resistant acid phosphatase (TRAP) activity (Fernańdez-Tresguerres et al, 2006;Perez-Amodio et al, 2006;Hayman, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, there was a direct relationship between the presence of ALP and the correct mineralization of bone tissue in vertebrates (Delmas et al, 2000;Fernańdez-Tresguerres et al, 2006;Kuo and Chen, 2017). Another phosphatase fraction in bone tissue is an acid phosphatase, a marker of tartrate-resistant acid phosphatase (TRAP) activity (Fernańdez-Tresguerres et al, 2006;Perez-Amodio et al, 2006;Hayman, 2008). Finally, calcium and phosphorus in both bone and plasma represent systemic regulation of bone formation and remodeling, as these minerals are bioavailability indicators (Beck et al, 2000;Sugiura et al, 2003;Pombinho et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic and microstructural characterization in normal versus deformed jaws of rainbow trout (Oncorhynchus mykiss) from freshwater

Godoy,

Sandoval,

Vásquez

et al. 2023

Front. Mar. Sci.

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IntroductionDuring the processes of formation and maturation of farmed salmonids, bone deformities could be associated with changes in the mineralization levels of the axial skeleton and the bone-signaling pathways. Therefore, we aimed to evaluate the gene expression during bone formation and regeneration and their relationship with mineralization in rainbow trout with mandibular deformation.MethodsWe included five normal fish and five specimens with mandibular deformation in smolt rainbow trout weighing 400 g and measuring 25 to 35 cm in length. We assessed 1. serum metabolites, 2. microstructure and mandibular bone mineralization and, 3. gene expression of bone signaling pathways. These analyses were done to determine the main causes and/or mechanisms of deformity.Results and discussionOur results show a marked elevation of bone morphogenetic protein 2 (Bmp2). Also, we found a distinct expression pattern for transcriptional factors, observing diminished RUNX family transcription factor 2 (Runx-2) expression coupled with a simultaneous elevation of osterix (Osx) levels. We also observed decreased osteocalcin and alkaline phosphatase levels related to mineral content loss and an increase in collagen type I as a compensatory structural response. In conclusion, rainbow trout deformation was characterized by demineralization, increased porosity without destruction of the organic matrix, and a moderate decrease in bone mineral content.

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“…However, research has mostly focused on optimizing the composition, and physicochemical and mechanical properties, of such materials; the requirement for further optimization of fundamental biological principles has often been neglected. Bone defect repair is an extremely complex physiological process, which is largely mediated and regulated by the injured cells and other recruited cells (Fernandez‐Tresguerres‐Hernandez‐Gil & Alobera‐Gracia, ; Fernandez‐Tresguerres‐Hernandez‐Gil, Alobera‐Gracia, del‐Canto‐Pingarron, & Blanco‐Jerez, ). Due to the small number of cells in defect sites caused by immune diseases, regeneration of bone defects is difficult, and self‐repair is often slow and ineffective (Arboleya & Castañeda, ; Sambuceti et al, ; Smilek, Ehlers, & Nepom, ).…”

Section: Introductionmentioning

confidence: 99%

An effective dual‐factor modified 3D‐printed PCL scaffold for bone defect repair

et al. 2020

J Biomed Mater Res

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Numerous bioactive molecules produced in cells are involved in the process of bone formation. We consider that appropriate, simultaneous application of two types of bioactive molecules would accelerate the regeneration of tissues and organs. Therefore, we combined aspirin-loaded liposomes (Asp@Lipo) and bone forming peptide-1 (BFP-1) on three dimensional-printed polycaprolactone (PCL) scaffold and determined whether this system improved bone regeneration outcomes. in vitro experiments indicated that Asp@Lipo/BFP-1at a 3:7 ratio was the best option for enhancing the osteogenic efficiency of human mesenchymal stem cells (hMSCs). This was confirmed in an in vivo cranial defect animal model. In addition, RNA-Seq was applied for preliminarily exploration of the mechanism of action of this composite scaffold system, and the results suggested that it mainly improved bone regeneration via the PI3K/AKT signaling pathway. This approach will have potential for application in bone tissue engineering and regenerative medicine. K E Y W O R D Saspirin, BFP-1, bone regeneration, drug delivery system, liposomes

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Resveratrol is able to increase bone mass and biomechanical properties on aged bone

Cited by 3 publications

References 0 publications

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Effect of monosodium glutamate on fetal development and progesterone level in pregnant Wistar Albino rats

Osteogenic and microstructural characterization in normal versus deformed jaws of rainbow trout (Oncorhynchus mykiss) from freshwater

An effective dual‐factor modified 3D‐printed PCL scaffold for bone defect repair

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