Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain

Palomera-Ávalos, Verónica; Griñán-Ferré, Christian; Izquierdo, Vanesa; Camins, Antoni; Sanfeliu, Coral; Canudas, Anna Maria; Pallàs, Mercè

doi:10.1016/j.exger.2017.11.014

Cited by 27 publications

(14 citation statements)

References 37 publications

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“…We have previously described that resveratrol dietary supplementation induced changes in cognition and molecular pathways in the hippocampus of aged [41,42] and AD mice models [43,44]. Here, we reported that body weight remained unchanged in the offspring from females supplemented with resveratrol before pregnancy in comparison with the sex control group, confirming the same effect in both sexes elicited by polyphenol, and corroborating previous studies [45,46].…”

Section: Discussionsupporting

confidence: 91%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

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A variety of environmental factors contribute significantly to age-related cognitive decline and Alzheimer’s Disease (AD). Nutrition can alter epigenetics, improving health outcomes, which transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in offspring. We feed females SAMP8 with resveratrol-enriched diet during two months prior to mating. Direct exposed F1 generation and the transgenerational F2 generation were investigated. Object novel recognition and Morris water maze demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring resulted from resveratrol fed mother showed increase AMPKα activation, mTOR inhibition and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways.

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Section: Discussionsupporting

confidence: 91%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo¹,

Palomera-Ávalos²,

López-Ruiz³

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…We have previously described that resveratrol dietary supplementation induced changes in cognition and molecular pathways in the hippocampus of aged [38,39] and AD mice models [33,40]. Here, we reported that body weight remained unchanged in the offspring from females supplemented with resveratrol before pregnancy in comparison with the sex control group, confirming the same effect in both sexes elicited by polyphenol, and corroborating previous studies [41,42].…”

Section: Discussionsupporting

confidence: 91%

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Izquierdo

Palomera-Ávalos

López-Ruiz

et al. 2019

IJMS

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A variety of environmental factors contribute significantly to age-related cognitive decline and memory impairment in Alzheimer’s Disease (AD) and other neurodegenerative diseases. Nutrition can alter epigenetics, improving health outcomes, which can be transmitted across generations; this process is called epigenetic inheritance. We investigate the beneficial effects of maternal resveratrol supplementation in the direct exposed F1 generation and the transgenerational F2 generation. The offspring was generated from females Senescence Accelerated Mouse-Prone (SAMP8) fed a resveratrol-enriched diet for two months prior to mating. Object novel recognition and Morris Water Maze (MWM) demonstrated improvements in cognition in the 6-month-old F1 and F2 generations from resveratrol fed mothers. A significant increase in global DNA methylation with a decrease in hydroxymethylation in F1 and F2 were found. Accordingly, Dnmt3a/b and Tet2 gene expression changed. Methylation levels of Nrf2 and NF-kβ genes promoters raised in offspring, inducing changes in target genes expression, as well as hydrogen peroxide levels. Offspring that resulted from a resveratrol fed mother showed increase AMPKα activation, mTOR inhibition, and an increase in Pgc-1α gene expression and Beclin-1 protein levels. Endoplasmic reticulum stress sensors were found changed both in F1 and F2 generations. Overall, our results demonstrated that maternal resveratrol supplementation could prevent cognitive impairment in the SAMP8 mice offspring through epigenetic changes and cell signaling pathways.

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“…On the other hand, it is well described that maternal HFD sensitizes offspring to metabolic dysregulation and that RV dietary supplementation improved most of the altered metabolic dysregulation [48]. Here, we reported that body weight is unchanged among groups, suggesting the same effect of the HFD across generations, and confirming the previous studies in which we did not observe changes in body weight and caloric intake in SAMP8 fed with HFD or HFD+RV [49,50]. Interestingly, we found that RV alleviates some MeS traits induced by HFD by reducing triglycerides and leptin plasma levels in all HFD+RV groups compared to the HFD group, suggesting that RV can promote peripheral effects regarding the hypertriglyceridemia and leptin resistance induced by HFD .…”

Section: Discussionsupporting

confidence: 91%

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

Izquierdo¹,

Palomera-Ávalos²,

Pallàs³

et al. 2020

Preprint

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Environmental factors as maternal high-fat diet (HFD) intake can increase the risk of age-related cognitive decline in adult offspring. The epigenetic mechanisms are a possible link between diet effect and neurodegeneration across generations. Here, we found a significant decrease in triglyceride levels in a high-fat diet with resveratrol HFD+RV group and the offspring. Firstly, we obtained better cognitive performance in HFD+RV groups and their offspring. Molecularly, a significant increase in 5-mC levels, as well as increased gene expression of Dnmt1 and Dnmt3a in HFD+RV F1 group, were found. Furthermore, a significantly increased of m6A levels in HFD+RV F1 were found, and there were changes in gene expression of its enzymes (Mettl3 and Fto). Moreover, we found a decrease in gene expression levels of pro-inflammatory markers such as Il1-β, Il-6, Tnf-α, Cxcl-10, Mcp-1 and Tgf-β1 in HFD+RV and HFD+RV F1 groups. Moreover, there was increased gene expression of neurotrophins such as Ngf and Nt3 and its receptors TrkA and TrkB. Likewise, an increase in protein levels of BDNF and p-Akt in HFD+RV F1 was found. These results suggest that maternal RV supplementation under HFD intake prevents cognitive decline in SAMP8 adult offspring, promoting a reduction in triglycerides and leptin plasma levels, changes in the pro-inflammatory profile, restoring the epigenetic landscape as well as synaptic plasticity.

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Resveratrol modulates response against acute inflammatory stimuli in aged mouse brain

Cited by 27 publications

References 37 publications

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Maternal Resveratrol Supplementation Prevents Cognitive Decline in Senescent Mice Offspring

Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations Under Maternal High-Fat Diet Intake: Multigenerational Epigenetic Inheritance.

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