Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm

Hemsinli, Dogus; Tümkaya, Levent; Ergene, Şaban; Karakişi, Sedat Ozan; Mercantepe, Tolga; Çınar, Seda; Yılmaz, Adnan

doi:10.1177/0960327120958039

Cited by 10 publications

(15 citation statements)

References 26 publications

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“… 2020 ; Hemsinli et al. 2021 ), drug-induced kidney injury (DKI) (Xiao et al. 2021 ) and sepsis-associated acute kidney injury (SA-AKI) (Wang et al.…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

Cao

Yang

et al. 2022

Pharmaceutical Biology

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Context Accumulated experimental evidence suggests that resveratrol (RSV) may have an effect on acute kidney injury (AKI) by inhibiting inflammation. However, the credibility of the evidence for this practice is unclear. Objective This study investigated the effect of RSV on AKI and the underlying mechanism. Methods We searched PubMed, EMBASE, and Web of Science from 2005 to April 2022 for controlled animal trials assessing the effect of conventional resveratrol versus placebo on renal function outcome after AKI. This study was registered within the International Prospective Register of Systematic Reviews (PROSPERO) as number CRD42022329596. Results We retrieved 455 studies, 25 studies comprising data of 436 animals that met the inclusion criteria. Our meta-analysis suggested that RSV treatment was significantly associated with lower levels of serum creatinine (Scr) and blood urea nitrogen (BUN). The greatest effects were recorded in low-dose (<20 mg/kg/day) groups rather than in high-dose (> 20 mg/kg/day) groups. For time-response effects, subgroup analysis indicated that intervention duration of RSV can influence the treatment effect, and more beneficial effects were observed when studies had a drug administration time of <2 weeks. Discussion and conclusions This systematic review of animal AKI studies showed a consistently favourable effect of RSV as compared to placebo on renal function outcomes that increased with lower TNF-α, IL-6, and IL-1β. RSV has a more beneficial effect on SA-AKI animal models than the others. When the RSV intervention dose was low (< 20 mg/kg/day) and the intervention time was <2 weeks, more benefits could be observed.

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“… 2020 ; Hemsinli et al. 2021 ), drug-induced kidney injury (DKI) (Xiao et al. 2021 ) and sepsis-associated acute kidney injury (SA-AKI) (Wang et al.…”

Section: Introductionmentioning

confidence: 99%

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

Cao

Yang

et al. 2022

Pharmaceutical Biology

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“…In addition, 3 studies adopted a unilateral renal I/R injury model ( 26 , 28 , 29 ), while a nephrectomy with contralateral clamping was performed in 6 of the remaining studies ( 21 , 24 , 25 , 32 – 34 ), and eight studies were conducted on both sides ( 19 , 21 – 23 , 27 , 30 , 31 , 35 ). The RSV dosage was <5 mg/kg in six studies ( 19 , 22 , 24 , 27 , 34 , 35 ), 5–10 mg/kg in three studies ( 20 , 21 , 23 ), and ≥10 mg/kg in six studies ( 25 , 26 , 28 – 33 , 36 ). Most studies used oral administration of RSV, while a few performed intravenous injection ( 18 , 19 , 22 , 27 , 33 , 35 ) and intraperitoneal injection ( 24 , 25 , 28 , 30 , 36 ).…”

Section: Resultsmentioning

confidence: 99%

Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis

Lan

Dun²,

Yao³

et al. 2023

Front. Nutr.

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Renal ischemia-reperfusion (I/R) injury may lead to acute kidney injury, which is characterized by high morbidity and mortality rates. Resveratrol (RSV) can be extracted from Chinese herbs, and multiple animal experiments have demonstrated its potential for renal protection. This systematic review evaluates the protective effect of RSV against renal I/R injury in animal models. The PubMed, Embase, Web of Science, and Science Direct databases were searched for animal experiments related to RSV in renal I/R injury from their establishment to June 2022. In total, 19 studies were included with 249 animals (129 treated with RSV and 120 as controls). The pooled analysis revealed that RSV administration significantly decreased serum creatinine (SCr) levels (16 studies, n = 243, WMD = −58.13, 95% CI = −79.26 to −37.00, p < 0.00001) and blood urea nitrogen (BUN) levels (12 studies, n = 163, WMD = −34.37, 95% CI = −46.70 to −22.03, p < 0.00001) in the renal I/R injury model. The level of malondialdehyde (MDA), an oxidative stress index, was alleviated [7 studies, n = 106, standardized mean difference (SMD) = −6.05, 95% CI = −8.90 to −3.21, p < 0.0001] and antioxidant enzymes such as glutathione (GSH) (7 studies, n = 115, SMD = 9.25, 95% CI = 5.51–13.00, p < 0.00001) and catalase (CAT) (4 studies, n = 59, SMD = 8.69, 95% CI = 4.35–13.03, p < 0.0001) were increased after treatment of RSV. The subgroup analysis suggested that 5–10 mg/kg of RSV optimally protects against renal I/R injury as both the BUN and SCr levels were significantly decreased at this dosage. The protective effects of RSV against renal I/R injury might be attributed to multiple mechanisms, such as inhibiting oxidative stress, apoptosis, inflammation, fibrillation, and promoting autophagy. For a deeper understanding of the protective effects of RSV, experimental studies on animal models and large randomized controlled trials in humans are needed.

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“…To the I/Rep+DMSO group, 10 mg/kg DMSO was given intraperitoneally, and the same amount of saline was given to the I/Rep group (Table 1 ). [ 9 ]…”

Section: Methodsmentioning

confidence: 99%

Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture

Karakişi¹,

Hemsinli²,

Tümkaya³

et al. 2021

Turk Gogus Kalp Dama

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Background: The aim of this study was to examine the effects on the lungs of ischemia/reperfusion injury in a ruptured abdominal aortic aneurysm model in rats and to investigate the potential protective effects of resveratrol. Methods: Thirty-two male Sprague-Dawley rats were randomly divided into four groups: control, ischemia/reperfusion, sham (ischemia/ reperfusion + solvent/dimethyl sulfoxide), and ischemia/reperfusion + resveratrol. In the groups subjected to ischemia/reperfusion, following 60-min shock to the abdominal aorta, vascular clamps were attached from the levels of the infrarenal and iliac bifurcation. A total of 60-min ischemia was applied, followed by 120-min reperfusion. In the ischemia/ reperfusion + resveratrol group, intraperitoneal 10 mg/kg resveratrol was administered 15 min before ischemia and immediately after reperfusion. Malondialdehyde, glutathione, and catalase levels were analyzed and histopathological examination of the lung tissues was performed. Results: Malondialdehyde levels increased in the ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide groups, compared to the control group, while catalase levels decreased, and no significant difference was observed in the glutathione levels. Malondialdehyde levels decreased with the administration of resveratrol, while glutathione levels increased, and catalase levels remained unchanged. The increased inflammation in interstitial spaces, thickening in the alveolar septal walls, increased numbers of cleaved caspase-3 apoptotic pneumocytes, and increased histopathological lung damage scores observed in the ischemia/reperfusion and ischemia/reperfusion + dimethyl sulfoxide groups improved with the application of resveratrol. Conclusion: These findings suggest that resveratrol may exhibit a protective effect in preventing acute lung injury developing due to ischemia/reperfusion in ruptured abdominal aortic aneurysm surgery by reducing oxidative damage.

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Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm

Cited by 10 publications

References 26 publications

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

The anti-inflammatory activity of resveratrol in acute kidney injury: a systematic review and meta‐analysis of animal studies

Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis

Resveratrol against lung injury in an ischemia/reperfusion model of abdominal aortic rupture

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