Resveratrol protects against atherosclerosis, but does not add to the antiatherogenic effect of atorvastatin, in APOE*3-Leiden.CETP mice

Berbée, Jimmy F.P.; Wong, M.C.; Wang, Yanan; Hoorn, José W.A. van der; Khedoe, P. Padmini S.J.; Klinken, Jan B. van; Mol, Isabel M.; Hiemstra, Pieter S.; Tsikas, Dimitrios; Romijn, Johannes A.; Havekes, Louis M.; Princen, H.M.G.; Rensen, Patrick C.N.

doi:10.1016/j.jnutbio.2012.11.009

Cited by 51 publications

(37 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, resveratrol supplementation at 3 mg·kg -1 ·d -1 in a hypercholesterolemic rabbit model led to a reduction of atherosclerotic plaque size and density as well as a decrease in the initial layer thickness, which demonstrated that resveratrol had a potential therapeutic effect on AS [56,57] . However, researchers have noted that resveratrol does not add to the antiatherogenic effect of atorvastatin when these drugs are used together [58] . Hence, when resveratrol is applied in combination with other lipid-reducing drugs, their respective pharmacological functions should be fully examined.…”

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

193

116

View full text Add to dashboard Cite

Although various types of drugs and therapies are available to treat atherosclerosis, it remains a major cause of mortality throughout the world. Macrophages are the major source of foam cells, which are hallmarks of atherosclerotic lesions. Consequently, the roles of macrophages in the pathophysiology of atherosclerosis are increasingly investigated. Autophagy is a self-protecting cellular catabolic pathway. Since its discovery, autophagy has been found to be associated with a variety of diseases, including cardiovascular diseases, malignant tumors, neurodegenerative diseases, and immune system disorders. Accumulating evidence demonstrates that autophagy plays an important role in inhibiting inflammation and apoptosis, and in promoting efferocytosis and cholesterol efflux. These facts suggest the induction of autophagy may be exploited as a potential strategy for the treatment of atherosclerosis. In this review we mainly discuss the relationship between macrophage autophagy and atherosclerosis and the molecular mechanisms, as well as the recent advances in targeting the process of autophagy to treat atherosclerosis.

show abstract

Section: Pharmacological Intervention Of Autophagy In the Treatment Omentioning

confidence: 99%

The roles of macrophage autophagy in atherosclerosis

Shao

Han

Zeng³

et al. 2016

Acta Pharmacol Sin

193

116

View full text Add to dashboard Cite

show abstract

“…As it has been demonstrated in the tests with mice with diet induced hypercholesterolemia, RSV has protective effects on atherosclerosis. The test group showed a decrease in aortic area changed by atheromatous and in cholesterol level in blood plasma, an increase in number of stability markers of atherosclerotic plaque and improvement of macrophage function [4].…”

Section: The Biological Activity Of Resveratrolmentioning

confidence: 90%

“…In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is 4, …”

mentioning

confidence: 99%

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Borys

Khozmi

Kranc

et al. 2017

Advances in Cell Biology

View full text Add to dashboard Cite

Summary: Resveratrol (RSV) is one of the polyphenols -metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant. RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams' interest, which is shown by the significant number of publications devoted to this subject. Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is 4,

show abstract

“…Selected published findings obtained from the application of these protocols in vitro and in vivo studies are outlined below [17][18][19][20][21][22][23][24][25]. …”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…We evaluated whether resveratrol protects against atherosclerosis development in APOE*3-Leiden.CETP (E3L.CETP) mice and reduces oxidative stress [24]. E3L.CETP mice were fed for 14 weeks a cholesterol-rich diet without or with resveratrol (0.01 wt.%), atorvastatin (0.0027 wt.%), or both.…”

Section: Effects Of Resveratrol and Atorvastatin On 15(s)-8-iso-pgf 2mentioning

confidence: 99%