Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

Okawara, Mitsugi; Katsuki, Hiroshi; Kurimoto, Emi; Shibata, Haruki; Kume, Toshiaki; Akaike, Akinori

doi:10.1016/j.bcp.2006.11.003

Cited by 182 publications

(117 citation statements)

References 43 publications

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“…Dopaminergic neurons may also form a significant site of action for the neuroprotective effects of resveratrol. In fact, resveratrol protects dopamine neurons from a wide range of neurotoxic agents (Okawara et al, 2007). That the effects of red wine and an aqueous solution with the same ethanol content are markedly different are emphasized by two reports that red wine is actually protective against ethanol-Induced oxidative stress in rat liver (Kasdallah-Grissa et al, 2007;Assunção et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine

Ali

Bondy

2010

Brain Research

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Section: Discussionmentioning

confidence: 99%

Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine

Ali

Bondy

2010

Brain Research

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“…Similar mechanisms of age-related, glucose-elicited damage might also be involved in neurodegenerative disorders along with generalized oxidative/nitrosative stress. Indeed, it is suggested that a significant part of SIRT1's neuroprotective signalling could be mediated through p53 [234], including SIRT1's roles in AD and PD [39,98,151]. Sirtuin-mediated changes in p53 stability and TF activity also occur in an experimental model of hippocampal neuronal plasticity [112].…”

Section: Transcriptional and Post-transcriptional Regulators As Sirtumentioning

confidence: 99%

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Jęśko¹,

Strosznajder²

2016

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A b s t r a c tSirtuins vast number of targets in many cellular compartments, and some display additional enzymatic activities including mono(ADP-ribosyl)ation. SIRTs interact with multiple signalling proteins, transcription factors and enzymes including p53, FOXOs (forkhead box subgroup O), PPARs (peroxisome proliferator-activated receptors), NF-κB, and DNA-PK (DNA-dependent protein kinase). Sirtuins also interact extensively with the family of poly(ADPribose) polymerases (PARPs), a crucial and widespread class of NAD

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“…In cell culture isolated from the infant rat's midbrain, which had stroke,there has been observance of reduction of the reactive oxygen from Reactive Oxygen Species (ROS) and a significant increase in the level of extracellular glutathione as a result of RSV [26]. In the observed test group of rodents with models of stroke, a reduced stroke impact area and improved cognitive functions after parenteral and oral intake of RSV were observed.…”

Section: The Biological Activity Of Resveratrolmentioning

confidence: 99%

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

Borys

Khozmi

Kranc

et al. 2017

Advances in Cell Biology

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Summary: Resveratrol (RSV) is one of the polyphenols -metabolites common in plants,however it does not occur in animals. It occurs mainly in grape skin (Vitisvinifera), peanuts (Arachis hypogeal) and in the roots of (Polygonumcupidatum) a traditional Chinese curative plant. RSV has a preventive property against the most serious diseases of modern world such as cancer, neurodegenerative diseases and cardiovascular diseases. Due to pleiotropy, RSV is currently the main object of many research teams' interest, which is shown by the significant number of publications devoted to this subject. Animal and human conducted studies have shown very low bioavailability of RSV (approx. 2%), which is the result of rapid biotransformation to sulphate and to a lesser extent, to the glucuronide conjugates as well. The studies on the improvement of RSV bioavailability, which have beencarried out for many years, have contributed to the synthesis of the analogues of more chemopreventive and more desirable pharmacokinetic properties. In order to enhance antiproliferative activity and RSV bioavailability, series of methyl analogues were synthesized and this will be described later in more detail. An example of such a derivative is 4,

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Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults

Cited by 182 publications

References 43 publications

Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine

Red wine but not ethanol at low doses can protect against the toxicity of methamphetamine

Sirtuins and their interactions with transcription factors and poly(ADP-ribose) polymerases

Resveratrol and Its Analogues – Is It a New Strategy of Anticancer Therapy?

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