Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway

Wu, Yue; Pang, Yulian; Wei, Wei; Shao, Anwen; Deng, Cong; Li, Xiongfeng; Chang, Hao‐Yu; Hu, Piaopiao; Liu, Xuequn; Zhang, Xu

doi:10.1016/j.exer.2020.108249

Cited by 31 publications

(24 citation statements)

References 46 publications

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“…Resveratrol, a natural polyphenol (Figure 7a), has been shown to be an antioxidant, an inducer of autophagy, and to have neuroprotective properties (Suzuki & Koike, 2007; Wu et al, 2011, 2020). Because transportation defects in ATG9A, the key cargo of the AP‐4 complex and an autophagy factor, may play an important role in the etiology of AP‐4‐HSP (Davies et al, 2018), we investigated the effects of resveratrol in ap4s1 mutants.…”

Section: Resultsmentioning

confidence: 99%

Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52

Li,

Zhang,

Peng

2023

Intl J of Devlp Neuroscience

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Biallelic mutations in AP4S1, the σ4 subunit of the adaptor protein complex 4 (AP‐4), lead to autosomal recessive spastic paraplegia 52 (SPG52). It is a subtype of AP‐4‐associated hereditary spastic paraplegia (AP‐4‐HSP), a complex childhood‐onset neurogenetic disease characterized by progressive spastic paraplegia of the lower limbs. This disease has so far lacked effective treatment, in part due to a lack of suitable animal models. Here, we used CRISPR/Cas9 technology to generate a truncation mutation in the ap4s1 gene in zebrafish. The ap4s1 truncation led to motor impairment, delayed neurodevelopment, and distal axonal degeneration. This animal model is useful for further research into AP‐4 and AP‐4‐HSP.

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Section: Resultsmentioning

confidence: 99%

Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52

Li,

Zhang,

Peng

2023

Intl J of Devlp Neuroscience

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“…Resveratrol has shown anti-inflammatory, antioxidant, and anti-neoplastic effects, and has also shown therapeutic properties in various diseases. In assessments of metabolic derangements, some studies suggested that resveratrol increased the expression and activity of the protein deacetylase enzyme-silent information regulator 2/sirtuin-1 (SIRT1), which is a central molecule that modulated the body's response to diet and exercise [28][29][30]. In mice fed a high-caloric diet, treatment with resveratrol also increased insulin sensitivity and reduced insulin-like growth factor-1 (IGF-1) levels, to improve the lifespan [15,31,32].…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

Hsu

Chen

Wang

et al. 2021

CIMB

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Resveratrol is a key component of red wine and other grape products. Recent studies have characterized resveratrol as a polyphenol, and shown its beneficial effects on cancer, metabolism, and infection. This study aimed to obtain insights into the biological effects of resveratrol on myopia. To this end, we examined its anti-inflammatory influence on human retinal pigment epithelium cells and in a monocular form deprivation (MFD)-induced animal model of myopia. In MFD-induced myopia, resveratrol increased collagen I level and reduced the expression levels of matrix metalloproteinase (MMP)2, transforming growth factor (TGF)-β, and nuclear factor (NF)-κB expression levels. It also suppressed the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Resveratrol exhibited no significant cytotoxicity in ARPE-19 cells. Downregulation of inflammatory cytokine production, and inhibition of AKT, c-Raf, Stat3, and NFκB phosphorylation were observed in ARPE-19 cells that were treated with resveratrol. In conclusion, the findings suggest that resveratrol inhibits inflammatory effects by blocking the relevant signaling pathways, to ameliorate myopia development. This may make it a natural candidate for drug development for myopia.

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“…Of note is that RSV has also been demonstrated to exert cytoprotective effects, such as antioxidant and anti-inflammatory effects, through the activation of SIRT1, which is a critical regulator of a wide variety of cellular responses including inflammation, stress resistance, mitochondrial biogenesis and apoptosis [ 43 ]. Several studies revealed that RSV activates SIRT1 both, directly and indirectly via AMPK activation [ 44 , 45 , 46 , 47 ]. In this context, it is worth mentioning that evidence from an in vivo-study with rats has been gained that RSV also exerts a positive effect on thyroid function by stimulating TSH secretion via the hypothalamic-pituitary axis and increases iodide trapping in the thyroid and triiodothyronine levels in plasma [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Alleviates the Inhibitory Effect of Tunicamycin-Induced Endoplasmic Reticulum Stress on Expression of Genes Involved in Thyroid Hormone Synthesis in FRTL-5 Thyrocytes

Wen

Eder

Ringseis

2021

IJMS

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Recently, ER stress induced by tunicamycin (TM) was reported to inhibit the expression of key genes involved in thyroid hormone synthesis, such as sodium/iodide symporter (NIS), thyroid peroxidase (TPO) and thyroglobulin (TG), and their regulators such as thyrotropin receptor (TSHR), thyroid transcription factor-1 (TTF-1), thyroid transcription factor-2 (TTF-2) and paired box gene 8 (PAX-8), in FRTL-5 thyrocytes. The present study tested the hypothesis that resveratrol (RSV) alleviates this effect of TM in FRTL-5 cells. While treatment of FRTL-5 cells with TM alone (0.1 µg/mL) for 48 h strongly induced the ER stress-sensitive genes heat shock protein family A member 5 (HSPA5) and DNA damage inducible transcript 3 (DDIT3) and repressed NIS, TPO, TG, TSHR, TTF-1, TTF-2 and PAX-8, combined treatment with TM (0.1 µg/mL) and RSV (10 µM) for 48 h attenuated this effect of TM. In conclusion, RSV alleviates TM-induced ER stress and attenuates the strong impairment of expression of genes involved in thyroid hormone synthesis and their regulators in FRTL-5 thyrocytes exposed to TM-induced ER stress. Thus, RSV may be useful for the treatment of specific thyroid disorders, provided that strategies with improved oral bioavailability of RSV are applied.

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Resveratrol protects retinal ganglion cell axons through regulation of the SIRT1-JNK pathway

Cited by 31 publications

References 46 publications

Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52

Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52

Anti-Inflammatory Effects of Resveratrol on Human Retinal Pigment Cells and a Myopia Animal Model

Resveratrol Alleviates the Inhibitory Effect of Tunicamycin-Induced Endoplasmic Reticulum Stress on Expression of Genes Involved in Thyroid Hormone Synthesis in FRTL-5 Thyrocytes

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