Resveratrol reduces the inflammatory activation of endothelum in patients with coronary heart disease combined with autoimmune thyroiditis

Чекаліна, Наталія Ігорівна

doi:10.23950/1812-2892-2016-3-21-26

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…Ранее полученные нами данные о противовоспалительной и иммуномодулирующей активности ресвератрола могут опосредовать его тиреопротекторные эффекты [14,26].…”

Section: Discussionunclassified

“…Контакт FcγRII эндотелия с С-реактивным белком, который также является его лигандом, реализует проатерогенные эффекты -активацию моноцитарно-эндотелиальной адгезии, повышение NF-kB-сигналинга с экспрессией провоспалительных молекул [27]. Наши предыдущие исследования продемонстрировали существенное повышение в кровотоке количества циркулирующих эндотелиальных микрочастиц с экспрессией CD32 у больных ИБС, при этом, у больных ИБС в сочетании с АИТ этот показатель был достоверно выше [14]. Возможно, АТ к ТПО влияют и на FcγRII эндотелия и других клеток, моделируя опосредуемые им процессы.…”

Section: Discussionunclassified

“…Ранее нами выявлено, что ресвератрол способствовал уменьшению пула эндотелиальных микрочастиц, презентирующих CD32, и более существенно -у больных ИБС в сочетании с АИТ [14,26]. Эти результаты являются подтверждением его эндотелиопротекторного, противовоспалительного действия, а также поясняют тиреопротекторный эффект ресвератрола, реализующегося путём снижения патогенного действия АТ к ТПО посредством подавления экспрессии FcγRII [28].…”

Section: Discussionunclassified

“…Ресвератрол блокирует NF-kB-сигналинг и снижает экспрессию генов воспаления [11,22,29]. Данные эффекты ресвератрола могут обусловливать нормализацию тиреоидного кровотока в настоящем исследовании [11,14,26].…”

Section: Discussionunclassified

“…Наши предыдущие исследования показали наличие у ресвератрола противовоспалительного и эндотелиопротекторного эффектов при стабильной ишемической болезни сердца (ИБС) в сочетании с АИТ [11,14]. Как известно, ХСВ является важнейшим патогенетическим компонентом атерогенеза и, соответственно, ИБС.…”

Section: Introductionunclassified

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Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

Чекаліна

2017

J CLIN MED KAZ

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Objective: to study the influence of resveratrol on the structural and functional state of the thyroid gland by levels of thyroid hormones, antibodies and ultrasound data of the thyroid gland in patients with stable coronary heart disease (IHD) in combination with autoimmune thyroiditis (AIT).Methods: 110 patients took part in the study: 60 patients with IHD: stable angina pectoris, FCII, 30 of whom had concomitant AIT, euthyroid, 20 patients with AIT and 30 healthy volunteers. On the background of standard therapy (β-blockers, statins, aspirin), patients with IHD and IHD in combination with AIT were assigned resveratrol at a dose of 100 mg per day for 2 months. Before and after the course of therapy, patients were diagnosed with free thyroxine (T4 free), thyroid stimulating hormone (TSH) and antibodies to thyroperoxidase (AT-TPO). To all participants were made ultrasound of the thyroid gland with pulse-wave dopplerography.Results: In patients with IHD and AIT under the influence of resveratrol, the level in the blood of TSH decreased, T4 free increased, AT-TPO did not change significantly. The same dynamics of the studied indicators was found in patients with IHD. All patients with AIT had an increase in the values of the arterial thyroid blood flow. The use of resveratrol contributed to a decrease the velocity and index of blood flow resistance in the thyroid arteries, which may be associated with its anti-inflammatory, endothelioprotective, thyroprotective effects. There was no evidence of the effect of resveratrol on normal thyroid blood flow in patients with IHD.Conclusion: In patients with IHD in combination with AIT, the use of resveratrol improves thyroid functional status and thyroid blood flow parameters, which makes the relevance to use of resveratrol in treatment of AIT and IHD in combination with AIT.Keywords: resveratrol -autoimmune thyroiditis -ischemic heart disease -thyroid function -blood flow thyroid parameters. TұрАқты жүректің ишемиялық АУрУы ұштАстырА АУтоиммУнды тиреоидит бАр нАУқАстАрдА қАлқАншА безінің құрылымдық және фУнкционАлдық жАй-күйі тУрАлы ресверАтрол әсері чекалина н.и. 11 Украин медициналық, стоматологиялық академиясы», ішкі аурулар пропедевтикасы және жалпы практика кафедрасы, Полтава, Украина тҰжЫРЫМДАМА Мақсаты: Қалқанша безінің гормондары, антиденелер және аутоиммунды тиреоидит (AИT) бірге тұрақты жүректің ишемиялық ауруы (ЖИА) бар науқастарда қалқанша безінің УДЗ деректер деңгейлері бойынша қалқанша безінің құрылымдық және функционалдық жай-күйі туралы ресвератрол әсерін зерттеу.Зерттеудің әдістері: 110 пациенттер зерттеуге қатысты: ЖИА ауыратын 60: тұрақты стенокардия, FCII, айт бір мезгілде AИT, euthyroid, 20 науқас және 30 салауатты еріктілерді болды 30 олардың. стандартты терапия (β-блокаторларға, статины, аспирин) фонында, AИT ұштастыра ЖИА және ЖИА ауыратын науқастарға 2 ай бойы тәулігіне 100 мг дозада ресвератрол берілді. Алдында және терапия курсынан кейін, науқастар тегін тироксина (T4 тегін), қалқанша (AT-TPO) thyroperoxidase үшін гормонын (ТТГ) және анти...

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Section: Discussionunclassified

Section: Introductionunclassified

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Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

Чекаліна

2017

J CLIN MED KAZ

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Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease

Чекаліна

Burmak

Petrov

et al. 2018

Indian Heart Journal

114

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Objective The aim of this study was to determine the effect of quercetin on the indicators of chronic systemic inflammation (CSI) in stable coronary artery disease (CAD). Methods This study included 85 patients with CAD, stable angina pectoris, functional class (FC) II, and heart failure (НF) 0-І. Each patient was prescribed beta-blockers, statins, and aspirin. In addition, a total of 30 patients, forming the study group received quercetin at a daily dose of 120 mg for two months, while the remaining 55 patients made up the control group. The levels of cytokines, such as tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), and interleukin-10 (IL-10) in serum and the expression of the inhibitor of kappa B α (IkBα) gene in blood mononuclear cells, were determined. Results The increased levels of IL-1β and TNF-α, as well as a moderate increase in IL-10 levels, were detected in the serum of patients with CAD. The expression of the IkBα gene (2 –δСt ) did not differ significantly between the groups. Under the influence of quercetin, levels of IL-1β and TNF-α were reduced and IL-10 levels tended to decrease. In contrast, the serum levels of these cytokines did not change significantly in the control group. The administration of quercetin decreased the expression of the IkBα gene (0.0092 ± 0.0033 against 0.0261 ± 0.0166, р = 0.003; 2 –δδСt , 2.82 ± 1.39 times) in contrast to the control group. Conclusion Quercetin showed anti-inflammatory properties in patients with CAD, indicating a decrease in transcriptional activity of the nuclear factor of transcription kappa B (NF-kB).

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The Significance of 8-oxoGsn in Aging-Related Diseases

Zhang¹,

Li²

2020

Aging and disease

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Resveratrol reduces the inflammatory activation of endothelum in patients with coronary heart disease combined with autoimmune thyroiditis

Cited by 4 publications

References 14 publications

Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

Influence of resveratrol on the structural and functional state of the thyroid gland in patients with autoimmune thyroiditis combined with stable ischemic heart disease

Quercetin reduces the transcriptional activity of NF-kB in stable coronary artery disease

The Significance of 8-oxoGsn in Aging-Related Diseases

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