2005
DOI: 10.1007/s10637-005-5855-8
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Resveratrol regulates cellular PKC α and δ to inhibit growth and induce apoptosis in gastric cancer cells

Abstract: Resveratrol, a dietary phytoalexin, has emerged as a promising chemopreventive agent due to its antiproliferative and pro-apoptotic action toward cancer cells and its ability to inhibit tumor growth in animals. Gastric adenocarcinoma cells respond to resveratrol treatment with suppression of DNA synthesis, activation of nitric oxide synthase, induction of apoptosis and inhibition of total PKC and PKC alpha activity. Here we demonstrate that treatment of gastric adenocarcinoma SNU-1 cells with resveratrol resul… Show more

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Cited by 99 publications
(60 citation statements)
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“…In agreement with our prior studies showing PCK-d slowed G1 progression, there is increasing evidence that PKC regulates the cell cycle through multiple pathways (Arita et al, 1998;Toyoda et al, 1998;Besson and Yong, 2000;Graham et al, 2000;Zhu et al, 2000;Shanmugam et al, 2001;Wakino et al, 2001; Acevedo- Duncan et al, 2002;Kikkawa et al, 2002;La Porta et al, 2002;Lee et al, 2002;Lin et al, 2002;Brodie and Blumberg, 2003;Soh and Weinstein, 2003;Avazeri et al, 2004;Clark et al, 2004;Gavrielides et al, 2004;Leontieva and Black, 2004;Atten et al, 2005). In nontransformed rat intestinal epithelial crypt cells, PKC signaling mediates cell cycle exit through rapid downregulation of G1 cyclins and increased expression of Cip/Kip cyclin-dependent kinase inhibitors (Frey et al, 1997(Frey et al, , 2000Clark et al, 2004).…”
Section: Introductionsupporting
confidence: 86%
“…In agreement with our prior studies showing PCK-d slowed G1 progression, there is increasing evidence that PKC regulates the cell cycle through multiple pathways (Arita et al, 1998;Toyoda et al, 1998;Besson and Yong, 2000;Graham et al, 2000;Zhu et al, 2000;Shanmugam et al, 2001;Wakino et al, 2001; Acevedo- Duncan et al, 2002;Kikkawa et al, 2002;La Porta et al, 2002;Lee et al, 2002;Lin et al, 2002;Brodie and Blumberg, 2003;Soh and Weinstein, 2003;Avazeri et al, 2004;Clark et al, 2004;Gavrielides et al, 2004;Leontieva and Black, 2004;Atten et al, 2005). In nontransformed rat intestinal epithelial crypt cells, PKC signaling mediates cell cycle exit through rapid downregulation of G1 cyclins and increased expression of Cip/Kip cyclin-dependent kinase inhibitors (Frey et al, 1997(Frey et al, , 2000Clark et al, 2004).…”
Section: Introductionsupporting
confidence: 86%
“…Elevated expression of caspase 3 was observed in AGS and KATO-III cells after treatment with resveratrol. [77][78][79] In HT 29 cells the apoptotic effect of resveratrol is mediated partly by the induction of endoplasmic reticulum stress. Resveratrol induces cell cycle arrest at G 2 phase through the inhibition of CDK7 kinase activity.…”
Section: Gastrointestinal and Colorectal Cancermentioning
confidence: 99%
“…Resveratrol induced apoptosis in a number of cell types, including human prostate cancer cells (Hsieh et al, 2011), colon cancer cells (Marel et al, 2008), gastric cancer cells, and breast cancer cells (Atten et al, 2005). Resveratrol has been proposed not only as a cancer chemopreventive reagent, but also an adjuvant therapy in the treatment of cancer (Fukui et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…PKC family has more than 12 isoforms, including the conventional PKCs (cPKCα, βI/βII, γ), novel PKCs (nPKC-δ, -ε, -η), and atypical PKCs (aPKCζ), which have been found to exist in various cells. PKCs play an important role in colon carcinogenesis (Atten et al, 2005).…”
Section: Introductionmentioning
confidence: 99%