Resveratrol supplementation significantly influences obesity measures: a systematic review and dose–response meta‐analysis of randomized controlled trials

Abstract

This study aimed to summarize earlier randomized controlled trials on the effects of resveratrol supplementation on body weight (BW), body mass index (BMI), waist circumference (WC) and fat mass (FM). We searched PubMed, SCOPUS, Cochrane Library and Google Scholar from inception to April 2018 using relevant keywords. All clinical trials investigating the effects of resveratrol supplementation on BW, BMI, WC and FM in adults were included. Overall, 28 trials were included. Pooled effect sizes suggested a significant effect of resveratrol administration on weight (weighted mean differences [WMD]: À0.51 kg, 95% confidence interval [CI]: À0.94 to À0.09; I 2 = 50.3%, P = 0.02), BMI (WMD: À0.17 kg m À2 , 95% CI: À0.32, À0.03; I 2 = 49.6%, P = 0.02) and WC (WMD: À0.79 cm, 95% CI: À1.39, À0.2; I 2 = 13.4%, P = 0.009), respectively. However, no significant effect of resveratrol supplementation on FM was found (WMD: À0.36%, 95% CI: À0.88, 0.15; I 2 = 0.0%, P = 0.16). Findings from subgroup analysis revealed a significant reduction in BW and BMI in trials using resveratrol at the dosage of <500 mg d À1 , those with long-term interventions (≥3 month), and performed on people with obesity. Taken together, the data suggest that resveratrol supplementation has beneficial effects to reduce BW, BMI and WC, but not FM.

The Effect of Resveratrol Supplementation on Cardio‐Metabolic Risk Factors in Patients with Type 2 Diabetes: A Randomized, Double‐Blind Controlled Trial

“…However, one study reached null results (Bo et al, ). In a recent meta‐analysis study including 28 trials, resveratrol supplementation showed a beneficial significant effect on weight, BMI, and WC without any significant effect on FM (Mousavi et al, ). Contrary to these findings, another meta‐analysis with fewer included studies found no significant effect of resveratrol administration on body weight and BMI (Christenson et al, ).…”

“…It seems that some factors like type of resveratrol supplement (pure resveratrol or resveratrol‐enriched extract), supplementation dosage, intervention duration, and health status of population contributed to the contradictory findings. Furthermore, it seems that resveratrol had a positive effect in studies with an overweight or obese population (Mousavi et al, ).…”

Association between adherence to MIND diet and general and abdominal obesity: a cross-sectional study

“…Although this dietary pattern has been constructed by combining Mediterranean and DASH dietary patterns, it has some advantages over these eating patterns. The MIND diet uniquely emphasizes on the consumption of berries and beans, which might influence body weight because of their content of resveratrol and fiber [30,31]. In addition, low intake of calorie-dense foods, including fast and fried foods, pastries and sweets and butter and margarines, in this dietary pattern might further explain its probable beneficial effect on weight control [32][33][34].…”

Gutsy red wine: Could this be a literal meaning in terms of gut microbial diversity?

“…There is also some evidence that resveratrol, another polyphenol found in red wine, has potential beneficial effects on reducing weight gain. A systematic review and dose‐response meta‐analysis of randomised controlled trials ( n = 28) of resveratrol supplementation of <500 mg/day for at least 3 months, in people with obesity, found small but statistically significant reductions in weight (−0.5 kg) and waist circumference (−0.79 cm) (Mousavi et al 2019). Proposed mechanisms, mostly from animal and cell studies, include resveratrol’s antioxidant and anti‐inflammatory properties, as well as increased fatty acid oxidation, decreased fatty acid synthesis, increased thermogenesis and energy expenditure and inhibition of digestive enzymes (Farhat et al 2017).…”