Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3<sup>Tyr705</sup> phosphorylation

Sun, Xiaodong; Xu, Qianqian; Zeng, Lian; Xie, Lin; Zhao, Qiang; Xu, Hongxia; Wang, Xuanbin; Jiang, Nan; Fu, Pan; Sang, Ming

doi:10.1002/cam4.3510

Cited by 34 publications

(19 citation statements)

References 63 publications

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“…The chemopreventive and anticancer effects of RSV, the object of this study, have been documented by in vivo and clinical studies in a wide variety of tumor cell types [ 31 , 32 , 33 ]. Numerous studies have reported the strong effect of RSV on the inhibition of cellular growth [ 34 ] in several cancer cells [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ], while some data have reported this effect on OS cells [ 43 , 44 ], motivating us to investigate it. Indeed, in line with the data reported in the literature, the current results show how the effects of different concentrations of RSV on OS cell lines (MG-63, Saos-2, KHOS, U-2 OS) at different experimental times (24, 48, or 72 and 144 h), have dose- and time-dependent effects on OS cell proliferation ( Figure 1 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

et al. 2022

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Osteosarcoma (OS) is the most common primary bone sarcoma affecting the life of pediatric patients. The clinical treatment faces numerous difficulties, including the adverse effects of chemotherapies, chemoresistance, and recurrences. In this study, the effects of resveratrol (RSV), a natural polyphenol, on OS cell lines were investigated to evaluate its action as an adjuvant therapy to the current chemotherapy regimens. RSV exhibited multiple tumor-suppressing activities on OS cell lines, inducing a series of critical events. We found (1) a cell growth inhibition due to an increase in cell distress, which was, in part, due to the involvement of the AKT and caspase-3 pathways, (2) an increase in cellular differentiation due to major gene expression levels of the osteoblastic differentiation genes, (3) an inhibition of IL-6 secretion due to an epigenetic effect on the IL-6 promoter, and (4) an inhibition of OS cells migration related to the decrease in IL-8 secretion levels due to an epigenetic effect on its promoter. Finally, the cotreatment of RSV with doxorubicin and cisplatin increased their cytotoxic effect on OS cells. Although further investigations are mandatory, it seems RSV might be a promising therapeutic adjuvant agent for OS cell treatment, exerting an antitumor effect when combined with chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

et al. 2022

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“…It has been reported that resveratrol can exert its antitumor effects on breast cancer, lung cancer, thyroid cancer, colon cancer, rectal cancer, prostatic cancer, cervical cancer, ovary cancer, and osteocarcinoma by regulating signaling pathways such as extracellular regulated protein kinases (ERK) pathway, Notch pathway, Sirtuin (SIRT)/β‐catenin pathway, Wnt pathway, nuclear factor kappa light chain enhancer of activated B cells (NF‐κB) pathway, mitogen‐activated protein kinase (MAPK) pathway, AMP‐dependent protein kinase (AMPK)/ mechanistic target of rapamycin (mTOR) pathway and phosphatidylinositol3‐kinase (PI3K)/protein kinase B (Akt)/mTOR pathway, etc. (Bian et al, 2020; Buhrmann et al, 2020; Dariya et al, 2020; Khusbu et al, 2020; Li, Wang, et al, 2019; Liu et al, 2018; Peng & Jiang, 2018; Sun et al, 2020; Vargas et al, 2020; Wang et al, 2020; Yang et al, 2021).…”

Section: Overview Of Resveratrolmentioning

confidence: 99%

The protective role of resveratrol in diabetic wound healing

Bi,

Qin,

Wang

et al. 2023

Phytotherapy Research

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Diabetic wounds are severe complications of diabetes mellitus (DM), which have difficulty in healing. Although diverse treatments have been used, the prognosis of diabetic wounds is not satisfactory; therefore, an effective therapy to accelerate diabetic wound healing is urgently needed. In our review, we summarized that resveratrol can promote diabetic wound healing by protecting against hyperglycemia, inflammation, oxidative stress, vascular pathology, infection, and peripheral neuropathy. To clarify it clearly, we highlighted its underlying mechanisms of protective effects of resveratrol against diabetic wounds, and high‐quality studies are needed to firmly establish its clinical efficacy. Otherwise, with the development of material sciences, resveratrol can exert its therapeutic effectiveness efficiently; however, more high‐quality studies are needed to confirm the clinical efficacy of resveratrol on diabetic wounds.

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“…These results provide preclinical evidence for the effectiveness of RES in the treatment of ovarian cancer. Furthermore, it was reported that resveratrol could reverse EMT of cervical cancer cell via inhibiting STAT3 Tyr705 phosphorylation (44).…”

Section: Genitourinary Malignancymentioning

confidence: 99%

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

et al. 2021

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Epithelial-to-mesenchymal transition (EMT), a complicated program through which polarized epithelial cells acquire motile mesothelial traits, is regulated by tumor microenvironment. EMT is involved in tumor progression, invasion and metastasis via reconstructing the cytoskeleton and degrading the tumor basement membrane. Accumulating evidence shows that resveratrol, as a non-flavonoid polyphenol, can reverse EMT and inhibit invasion and migration of human tumors via diverse mechanisms and signaling pathways. In the present review, we will summarize the detailed mechanisms and pathways by which resveratrol and its analogs (e.g. Triacetyl resveratrol, 3,5,4’-Trimethoxystilbene) might regulate the EMT process in cancer cells to better understand their potential as novel anti-tumor agents. Resveratrol can also reverse chemoresistance via EMT inhibition and improvement of the antiproliferative effects of conventional treatments. Therefore, resveratrol and its analogs have the potential to become novel adjunctive agents to inhibit cancer metastasis, which might be partly related to their blocking of the EMT process.

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Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3^Tyr705 phosphorylation

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 34 publications

References 63 publications

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

The protective role of resveratrol in diabetic wound healing

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

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Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3Tyr705 phosphorylation

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 34 publications

References 63 publications

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

Multiple Effects of Resveratrol on Osteosarcoma Cell Lines

The protective role of resveratrol in diabetic wound healing

Resveratrol and Its Analogs: Potent Agents to Reverse Epithelial-to-Mesenchymal Transition in Tumors

Contact Info

Product

Resources

About

Resveratrol suppresses the growth and metastatic potential of cervical cancer by inhibiting STAT3^Tyr705 phosphorylation