Retention behavior of carboxylic acids and their quaternary ammonium ion pairs in reversed phase chromatography with acetonitrile as organic modifier in the mobile phase

Tilly-Melin, A.; Askemark, Yvonne; Wahlund, Karl-Gustav; Schill, G

doi:10.1021/ac50043a045

Cited by 167 publications

(26 citation statements)

References 18 publications

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“…It can be seen that the linear regression coefficient according to eqns. (l) and (2) in most cases is larger than 0.99, which strongly support the validity of eqns. (l) and (2).…”

supporting

confidence: 80%

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Zou

Zhang

Hong

et al. 1993

Journal of Liquid Chromatography

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The logarithm of capacity factor Inkip. in reversed-phase ionpair liquid chromatography (RP-IPC) llnearly deceases with methanol concentration (Cb), and the logarithm of capacity factor lnkic in ion-chromatography (IC) linearly decreases with the logarithm of salt concentration (lnCs) . The intercept (Inkyp, A) and slope (tip, B) values of a linear relationship between lnkip vs. Cb in RP-IPC and lnkj, vs. lnC, in IC were obtained. The logarithm of capacity factor in RP-HPLC and the logarithm of capacity factor in IC, the solute charges and the parameter B in IC have been selected as the descriptors of solute molecular and electrostatic interaction respectively. It has been observed that the logarithm of capacity factors, the parameters lnkip and c in RP-IPC can be well correlated with the logarithm of capacity factors in RP-HPLC and the logarithm of capacity factors in IC, the solute charges and the parameter B. Both the lnkkp in RP-HPLC and the lnkic in Ic, the solute charges and the parameter B made a positive contribution to the retention and the parameter Ink in RP-PC, but made a negative contribution to the parameter c in RP-IPC. It can be concluded that both the molecular and the electrostatic interaction play major role in retention of the ionic solutes in RP-IPC. iP iP iP 1069

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“…It can be seen that the linear regression coefficient according to eqns. (l) and (2) in most cases is larger than 0.99, which strongly support the validity of eqns. (l) and (2).…”

supporting

confidence: 80%

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Zou

Zhang

Hong

et al. 1993

Journal of Liquid Chromatography

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“…The retention behaviour of some organic anions as quaternary ammonium ion pairs on hydrophobic alkyl modified silica [22] or non polar poly(styrene-divinylbenzene) adsorbent [23] has been already described. When an analyte ion, X − , is introduced in the chromatographic system above specified, it is distributed to the stationary phase as the ion pair QX, which competes with QC (where C − is the co-anion of TBA + ) and QZ (where Z − indicate a competing anion, e.g.…”

Section: Chromatographic Behaviour Of Mpa and Mpagmentioning

confidence: 99%

Simultaneous determination of free mycophenolic acid and its glucuronide in serum of patients under mycophenolate mophetil therapy by ion-pair reversed-phase liquid chromatography with diode array UV detection

Aresta

Palmisano

Zambonin

et al. 2004

Journal of Chromatography B

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“…The amount of the modifier adsorbed onto the AGP surface (n 0 ) was obtained from the total amount of the organic solvent measured in the eluate by compensating with the content of modifier in dead volume. 18 The dead volume of the column was determined with injection of water. All chromatographic data reported are the mean of two parallel measurements.…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Study on the sorption properties of α₁‐acid glycoprotein (AGP)‐based stationary phase modified by organic solvents

et al. 2003

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An alpha(1)-acid glycoprotein, immobilized on silica (Chiral-AGP) is one of the most widely used chiral stationary phases for the enantiomeric separation of a wide variety of chiral drugs with several applications in the biological and clinical field. The aim of this work was to study the sorption properties of the AGP-based stationary phase, which may have crucial importance for enantioselectivity. New binding data to the mechanism of the chromatographic separation are presented. The sorption of both organic solvents, i.e., acetonitrile and dioxane, shows remarkable pH dependency. A fluorescence quenching study was carried out to elucidate structural changes of AGP in the presence of acetonitrile using 2,2,2-trichloroethanol as fluorescence quencher.

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Retention behavior of carboxylic acids and their quaternary ammonium ion pairs in reversed phase chromatography with acetonitrile as organic modifier in the mobile phase

Cited by 167 publications

References 18 publications

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Simultaneous determination of free mycophenolic acid and its glucuronide in serum of patients under mycophenolate mophetil therapy by ion-pair reversed-phase liquid chromatography with diode array UV detection

Study on the sorption properties of α₁‐acid glycoprotein (AGP)‐based stationary phase modified by organic solvents

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Retention behavior of carboxylic acids and their quaternary ammonium ion pairs in reversed phase chromatography with acetonitrile as organic modifier in the mobile phase

Cited by 167 publications

References 18 publications

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Correlation of Sulphonic Acid Retention Values in RP-IPC with Retention Values in RP-HPLC and Ion Chromatography

Simultaneous determination of free mycophenolic acid and its glucuronide in serum of patients under mycophenolate mophetil therapy by ion-pair reversed-phase liquid chromatography with diode array UV detection

Study on the sorption properties of α1‐acid glycoprotein (AGP)‐based stationary phase modified by organic solvents

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Study on the sorption properties of α₁‐acid glycoprotein (AGP)‐based stationary phase modified by organic solvents