Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

Wenk, Gary L.; Grey, Christine; Ingram, Donald K.; Spangler, Edward L.; Olton, David S.

doi:10.1037/0735-7044.103.3.688

Cited by 35 publications

(15 citation statements)

References 13 publications

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“…The role of AMPA receptors in synaptic plasticity is less well established than that of NMDA-selective L-glutamate receptors, which have been demonstrated to be of considerable importance in longterm potentiation, an important synaptic model for learning and memory (Bliss and Collingridge, 1993;Davis, S. et al, 1992), as well as in a wide variety of learning models (Wenk et al, 1989;Moms, 1990;Melan et al, 1991;Welzl et al, 1991;McCabe and Horn, 1991;. It is widely known, however, that AMPA and NMDA receptors have closely associated roles in long-term potentiation (Bliss and Collingridge, 1993), and that AMPA receptors are thought to assist in the activation of NMDA receptors, by providing the postsynaptic depolarization necessary to relieve the NMDA receptor's voltage-sensitive Mg2+ blockage (Massicote and Baudry, 1991;Bliss and Collingridge, 1993).…”

Section: Introductionmentioning

confidence: 99%

Involvement of AMPA Receptors in Maintenance of Memory for a Passive Avoidance Task in Day‐old Domestic Chicks (Gallus domesticus)

Steele

Stewart

1995

Eur J of Neuroscience

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Day-old chicks (Gallus domesticus) were trained on a one-trial passive avoidance task where the aversive stimulus was an unpleasant tasting substance, methyl anthranilate. Chicks were killed 6.5 h after training. The kinetic parameters of [3H] alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) binding were determined using quantitative receptor autoradiography and Scatchard analyses in 15 discrete forebrain regions of trained and control (water-trained) chicks, revealing two components of binding in each. KD values showed some regional variation, but were 22.2 +/- 1.1 nmol l-1 for the high-affinity component and 685 +/- 25 nmol l-1 for the low-affinity component of binding to whole forebrain sections from control chicks. Analyses also revealed that Hill coefficients were significantly less than 1 in all regions measured. A significant decrease in KD for the low-affinity component occurred bilaterally in the intermediate and medial hyperstriatum ventrale (IMHV; left, 34.8%; right, 33.3%), a region that has previously been shown to be implicated in the processes of memory formation, following passive avoidance training. A significant decrease in KD for the high-affinity component occurred in the right palaeostriatum augmentatum (19.5%). Significant decreases in Bmax accompanied the KD alterations in both cases. Additionally, bilateral intracerebral injections (administered 4.5-5.5 h after training) into the IMHV of 500 nmol l-1 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), a selective antagonist of non-NMDA glutamate receptors (particularly AMPA receptors), resulted in amnesia for one-trial passive avoidance training in day-old chicks tested 6.5 h after training.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Introductionmentioning

confidence: 99%

Involvement of AMPA Receptors in Maintenance of Memory for a Passive Avoidance Task in Day‐old Domestic Chicks (Gallus domesticus)

Steele

Stewart

1995

Eur J of Neuroscience

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“…However, they also observed a positive correlation between errors in the maze and hippocampal glutamate binding in 3 to 4mths old yound adult rats. In constrast, a positive correlation between good performance in the Morris water maze and the number of glutamate binding sites in the hippocampus was also demonstrated in aged rats (Wenk et al, 1989). In these two studies, constant but single concentrations of the ligand QH)-glutamate were used for the binding assay.…”

Section: Discussionmentioning

confidence: 95%

“…As mentioned above, Ingram et al (1992) and Wenk et al (1989) used one single constant concentration of (3H)-glutamate. In contrast, Pelleymounter et al (1990), Keller et al (1992), Scheuer et al (1995) and we in this study used either (3H)-CPP or QH)-MK-801 as ligands to determine the total number of existing NMDAreceptors by saturation with increasing ligand concentrations as Bma x calculated from Scatchard plots.…”

Section: Discussionmentioning

confidence: 99%

Learning abilities depend on NMDA-receptor density in hippocampus in adult rats

Stecher

Müller

Hoyer

1997

J. Neural Transmission

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The hippocampal NMDA-receptor is predominantly involved to establish long-term potentiation (LTP) which is assumed to underlie fundamental molecular mechanisms of learning and memory. In the present study, NMDA-receptor density was investigated in parietotemporal cerebral cortex and in hippocampus of commonly bred naive adult male Wistar rats which had performed well or poorly in the passive avoidance paradigm. NMDA-receptor binding was determined in saturation experiments using (3H) MK-801 as a ligand and data for KD and Bmax were calculated from Scatchard plots. In general, higher NMDA receptor density was found in the hippocampus as compared to parietotemporal cerebral cortex. This regional difference became particularly obvious in good performers but was abolished in poor performers. In the hippocampus, a significantly higher NMDA-receptor density could be found in rats which had performed well in the passive avoidance task as compared to poor performers. In contrast, no such differences could be found in parietotemporal cerebral cortex. The data may indicate that the reduction in hippocampal NMDA-receptor density is of functional importance, for cognitive abilities in both physiological and pathophysiological conditions.

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“…Ibotenic acid-induced striatal lesions, which damaged both cholinergic and noncholinergic neurons, also lead to deficits in the spatial navigation of the water maze task . Wenk et al (1989) showed a significant correlation between the number of L-[ 3 H]glutamate and NMDA-displaceable L-[ 3 H]glutamate binding sites in the hippocampus and neocortex of rats and the mean number of errors during retention in the Stone maze and suggest that N-methyl D-aspartate (NMDA) receptors play an important role in learning and memory functions. Thus, the relationship between learning and memory dysfunctions and lesions other than those in cholinergic neurons should be considered.…”

Section: Experimental Acetylcholinementioning

confidence: 99%

Failure in learning task and loss of cortical cholinergic fibers in microsphere-embolized rats

Takagi

Miyake²,

Taguchi³

et al. 1997

Exp Brain Res

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The present study was undertaken to elucidate the pathological changes in learning and memory functions and in the metabolism of cortical cholinergic neurons following microsphere embolism in the rat. Microspheres (48 microm) were injected into the right internal carotid artery of rats. Learning and memory functions were measured 7 or more days after the embolism by active and passive avoidance, and water maze tasks. In the biochemical study, cortical acetylcholine and choline contents, and choline acetyltransferase activity were measured. Cortical acetylcholinesterase-containing fibers were quantitatively estimated in the embolized rat. The active and passive avoidance, and water maze tasks were impaired in the microsphere-embolized rat. In the histochemical study, the density of cortical acetylcholinesterase-containing fibers of the ipsilateral hemisphere of the microsphere-embolized rat was decreased, but cell density was unchanged. Furthermore, microsphere embolism decreased the cortical acetylcholine concentration and choline acetyltransferase activity and increased the choline concentration. The results suggest that microsphere embolism causes severe damage to cortical cholinergic neurons, which may be, at least in part, related to the impairment of learning and memory functions in the sustained brain ischemia.

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Retention of maze performance inversely correlates with N-methyl-D-aspartate receptor number in hippocampus and frontal neocortex in the rat.

Cited by 35 publications

References 13 publications

Involvement of AMPA Receptors in Maintenance of Memory for a Passive Avoidance Task in Day‐old Domestic Chicks (Gallus domesticus)

Involvement of AMPA Receptors in Maintenance of Memory for a Passive Avoidance Task in Day‐old Domestic Chicks (Gallus domesticus)

Learning abilities depend on NMDA-receptor density in hippocampus in adult rats

Failure in learning task and loss of cortical cholinergic fibers in microsphere-embolized rats

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