Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls

Welker, Susanne G.; Pfau, Maximilian; Heinemann, M.; Schmitz-Valckenberg, Steffen; Holz, Frank G.; Finger, Robert P.

doi:10.1167/iovs.18-23878

Cited by 34 publications

(45 citation statements)

References 39 publications

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“…Both, mesopic and darkadapted microperimetry revealed reduced retinal sensitivity in iAMD patients compared to controls. These results are in accordance with findings from previous studies, which found mesopic microperimetry to be a good functional test in iAMD [20,48,49,12,14,37,8,50,5]. Contrary to our findings Nebbioso and colleagues reported a reduction in scotopic sensitivity but not mesopic sensitivity in patients with hard drusen [51].…”

Section: Discussionsupporting

confidence: 93%

“…In our sample of more advanced AMD mesopic microperimetry seemed to be a better test compared to dark-adapted microperimetry. This may be attributable to the higher variability of dark-adapted microperimetry compared to mesopic microperimetry [37].…”

Section: Discussionmentioning

confidence: 99%

“…For mesopic testing, the standard white LED of the device was used and for dark-adapted red testing the additional red LED (627 nm) was used to project the stimuli. As previously described a customized stimulus PLOS ONE grid was used that consisted of 33 points located at 0˚, 1˚, 3˚, 5˚and 7˚from fixation [37]. All patients underwent mesopic and dark-adapted microperimetry.…”

Section: Visual Function Testsmentioning

confidence: 99%

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Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests

et al. 2020

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The purpose of the study was to evaluate the diagnostic accuracy of visual function tests in intermediate age-related macular degeneration (iAMD). A total of 62 subjects (38 patients with iAMD and 24 controls) were included and underwent several functional assessments: Best-corrected visual acuity (BCVA), low luminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Vanishing Optotypes Acuity Charts (MAC), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts (IReST) and mesopic and dark-adapted microperimetry (S-MAIA, CenterVue, Padova, Italy). Groups were compared using non-parametric Wilcoxon rank sum tests and ROC analyses. Linear regression was used to control for confounding. Results showed that all visual function test performances except the IReST were significantly reduced in iAMD patients compared to controls (p < 0.05). These effects did not alter after controlling for age and sex. Best discrimination between iAMD and controls yield the combination of LLVA and contrast sensitivity as well as MAC-VA and contrast sensitivity (ROC area under the curve 0.95 and 0.93, respectively). Our results suggest that LLVA, MAC-VA, contrast sensitivity and mesopic and dark-adapted microperimetry can capture visual impairment characteristic for iAMD. Best discrimination against iAMD is achieved with a combination of two tests.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Visual Function Testsmentioning

confidence: 99%

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Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests

et al. 2020

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“…24 As previously described, a customized stimulus grid was used that consisted of 33 points located at 0°, 1°, 3°, 5°, and 7°from fixation. 25 First, mesopic testing was performed. Patients were not dark-adapted, but the room light was switched off just before the examination.…”

Section: Functional Testingmentioning

confidence: 99%

Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular Degeneration

Pondorfer

Wintergerst

Zadeh

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To assess which visual function measures are most strongly associated with overall retinal drusen volume in age-related macular degeneration (AMD). METHODS. A total of 100 eyes (16 eyes with early AMD, 62 eyes with intermediate AMD, and 22 eyes from healthy controls) were recruited in this cross-sectional study. All subjects underwent several functional assessments: best-corrected visual acuity (BCVA), lowluminance visual acuity (LLVA), visual acuity (VA) measured with the Moorfields Acuity Chart (MAC-VA), contrast sensitivity with the Pelli-Robson test, reading speed using the International Reading Speed texts, and mesopic and dark-adapted microperimetry. Drusen volume was automatically determined based on optical coherence tomography using an approach based on convolutional neural networks. The relationship between drusen volume and visual function was assessed with linear regressions controlling for confounders. RESULTS. Mean drusen volume and MAC-VA differed significantly among all AMD stages and controls (P < 0.001). In univariate linear regression, LLVA, MAC-VA, contrast sensitivity, and mesopic and dark-adapted microperimetry were significantly negatively associated with the overall drusen volume (all P < 0.006). After controlling for AMD stage, age, and the presence of subretinal drusenoid deposits, MAC-VA and mesopic and darkadapted microperimetry were still significantly associated with drusen volume (P = 0.008, P = 0.023, and P = 0.022, respectively). CONCLUSIONS. Our results suggest that MAC-VA, as well as mesopic and dark-adapted microperimetry, might indicate structural changes related to drusen volume in early stages of AMD.

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“…Microperimetry is becoming increasingly popular for the assessment of the differential light sensitivity in macular disease. [1][2][3][4][5][6][7][8] The principal advantage of microperimetry compared with standard automated perimetry (SAP) is the provision of fundus tracking that adjusts the position of each stimulus location to account for fixation instability and/or for eccentric fixation, both of which are common in late stage macular disease. Additionally, the measured sensitiv-ity at any given stimulus location is superimposed, in real time, upon the fundus image thereby providing an indication of the topographical relationship between visual function and fundal abnormality.…”

Section: Introductionmentioning

confidence: 99%

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

Cassels

Wild

Margrain

et al. 2019

Trans. Vis. Sci. Tech.

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Purpose: The ''traffic light'' color designation of differential light sensitivity used in a number of microperimeters does not encompass the conventional Total and Pattern Deviation probability analyses adopted by standard automated perimetry. We determined whether the color designation is indicative of abnormality as represented by the ''gold standard'' Pattern Deviation probability analysis. Methods: Total and Pattern Deviation probability levels, using two different methods, were derived at each of 40 stimulus locations, within 78 eccentricity, from 66 ocular healthy individuals (66 eyes) who had undergone microperimetry with the Macular Integrity Assessment microperimeter. The probability levels were applied to the corresponding fields from each of 45 individuals (45 eyes) with age-related macular degeneration (AMD) and evaluated in relation to the color designation. Results: Sensitivities designated in orange encompassed the entire range of Pattern Deviation probability levels (from normal to P 1%). Those designated in green were mostly normal; those in red/black generally corresponded to the 1% probability level. Conclusions: The green and the red/black designations are generally indicative of normal and abnormal probability values, respectively. The orange designation encompassed all probability outcomes and should not be relied upon for visual field interpretation. The evidence base indicates replacement of the color designation of sensitivity in AMD by Total Deviation and Pattern Deviation analyses. Translational Relevance: The use of Total and Pattern Deviation probability analyses is not universal in all microperimeters, and the derivation of these values indicates that color coding will lead to errors in evaluating visual field loss.

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Retest Reliability of Mesopic and Dark-Adapted Microperimetry in Patients With Intermediate Age-Related Macular Degeneration and Age-Matched Controls

Abstract: FG, Finger RP. Retest reliability of mesopic and dark-adapted microperimetry in patients with intermediate age-related macular degeneration and age-matched controls. Invest

Cited by 34 publications

References 39 publications

Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests

Detecting vision loss in intermediate age-related macular degeneration: A comparison of visual function tests

Association of Visual Function Measures with Drusen Volume in Early Stages of Age-Related Macular Degeneration

Microperimetry in Age-Related Macular Degeneration: An Evidence-Base for Pattern Deviation Probability Analysis in Microperimetry

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