2023
DOI: 10.1101/2023.12.09.570944
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Rethinking Dormancy: Antibiotic Persisters are Metabolically Active, Non-Growing Cells

K M Taufiqur Rahman,
Ruqayyah Amaratunga,
Xuan Yi Butzin
et al.

Abstract: Bacterial persisters are a multidrug-tolerant subpopulation capable of surviving and resuscitating after lethal antibiotic treatment, leading to relapsing infections and the emergence of antibiotic resistance. We hypothesize that multiple persister subpopulations are within an isogenicEscherichia colipopulation, allowing them to survive lethal antibiotic stress. We conducted transcriptomic analyses at multiple time points with lethal ampicillin (Amp) antibiotic, and as expected, several genes were differential… Show more

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