“…To compensate for sensorimotor loss, central nervous system remodeling may occur in the brain’s white and gray matter by aberrant signaling [ 2 , 3 , 4 ]; progressive atrophic, microstructural, and biochemical changes [ 5 , 6 , 7 , 8 ]; an imbalance in excitation or inhibition [ 9 ], or a spatial shift in functional sensorimotor representation [ 10 ]. Cortical areas become muted when they fail to respond to stimulation, as occurs following brachial plexus and spinal cord damage, or they become maladaptive, as happens with the development of neuropathic pain and phantom sensations such as those associated with amputations [ 1 , 11 , 12 , 13 ]. However, despite this reorganization, the missing limbs remain strongly represented [ 14 , 15 ].…”