Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Karst, Sonja; Beiglboeck, Hannes; Scharinger, Raffael; Meyer, Elias Laurin; Mitsch, Christoph; Scholda, Christoph; Schmidt–Erfurth, U.

doi:10.1167/iovs.19-27977

Cited by 3 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have reported CC flow defects in the retina around laser scars, in the geographic atrophy or drusen area of dry AMD patients in Stargardt disease, etc. [3,4,14,15] CC defects with bare inner or middle choroidal vessels were observed in these studies. Hagag A M et al also reported CC flow voids using 8 mm × 8 mm SD-OCTA in patients with different genotypes [7].…”

Section: Discussionsupporting

confidence: 57%

Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography

Shen

Wang

et al. 2020

BMC Ophthalmol

View full text Add to dashboard Cite

Background To evaluate choroidal vascular changes, including choriocapillaris (CC) and middle/large choroidal vessels, in retinitis pigmentosa (RP) patients using wide-angle optical coherence tomography angiography (OCTA) and to determine whether changes in the choroidal vascularity have a relationship with visual function and retinal structural changes. Methods 34 patients with a confirmed diagnosis of RP and 48 controls were recruited. All patients underwent detailed ophthalmologic and imaging examinations, including two types of OCTA (Optovue, 3 × 3 mm, 6 × 6 mm; VG-200, 12 × 12 mm). CC defects were defined according to the choroidal vascular structure in five degrees. To evaluate middle and large choroidal vascular changes, the choroidal vascularity index (CVI), which was the luminance volume to the total choroidal volume, was used. Results Defects of choroidal vascularity of RP eyes were detected in comparison to control eyes. The defects were observed in the CC layer with a concentric or lobular pattern at different degrees. CVI, which was used to reflect middle/large choroidal vascularity, decreased in the perifoveal, pararetinal and periretinal regions in the RP eyes. CC defects degree were correlated with the BCVA (p = 0.001, r = − 0.556), the Humphrey indexes (mean deviation, MD, p < 0.001, r = − 0.673; PVF, p = 0.003, r = − 0.639; 10° mean sensitivity, 10° MS, p = 0.002, r = − 0.651) and microperimetry index (mean sensitivity, MS, p < 0.001, r = − 0.807). The preserved CC area (mean value: 28.65 ± 12.50 mm2) was negatively correlated with MS measured by microperimetry (p = 0.005, r = − 0.449). Ordinary regression analysis revealed that the CC defect degree was associated with the CVI of perifovea (p = 0.002, 95% CI: − 102.14 to − 24.01), the EZ length (p = 0.006, 95% CI: − 0.006 to − 0.001) and the VAD (vascular area density) of the DCP (deep capillary plexus) in the fovea (p = 0.022, 95% CI: 0.038–0.478). No correlations were detected between BCVA and CVI in any retinal regions. No correlations were found between the CVI and the VAD in any retinal regions. Conclusion The choroidal vascularity was widely defected in RP. Choriocapillaris and middle/large choroidal vascularity defects were correlated with each other. Visual function and retinal structural changes were found to be associated with choriocapillaris defects but not with middle/large choroidal vascular defects.

show abstract

Section: Discussionsupporting

confidence: 57%

Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography

Shen

Wang

et al. 2020

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…It is generally accepted that laser energy is mainly absorbed by retinal pigment epithelium (RPE), destroys RPE and photoreceptor cells, and injures surrounding retina and choriocapillaris. Both in retina and choroid, capillary dropout in the areas of laser scars (12). There are some studies have suggested that choroidal vessels in the untreated macular area increased after retinal peripheral photocoagulation (13,14).…”

Section: Discussionmentioning

confidence: 99%

Effects of panretinal photocoagulation on macular vascular density and Foveal avascular zone area in patients with severe non-proliferative diabetic retinopathy by optical coherence tomography angiography

Zhu¹,

Zhang²,

Liu³

2020

Preprint

View full text Add to dashboard Cite

Aim: To describe the changes of optical coherence tomography angiography (OCTA) characteristics in severe non-proliferative Diabetic Retinopathy(S-NPDR) eyes. And study the effect of Panretinal photocoagulation(PRP) on these characteristics.Methods: This is a prospective study including 31 eyes from 18 consecutive patients with S-NPDR and 31 eyes of healthy subjects. We measured macular vascular density (VD) and foveal avascular zone(FAZ) area by an OCTA device. All patients with S-NPDR underwent PRP treatment. In S-NPDR eyes, the VD and foveal avascular zone(FAZ) area were assessed at 1 week before PRP, 1 month, 3 months and 6 months following PRP.Results: Compared with the normal control group ,in superficial retinal capillary plexus (SCP), macular VD decreased in S-NPDR group expect foveal VD. In foveal ,p=0.7;In parafoveal and perifoveal, p＜0.001. In deep retinal capillary plexus (DCP), macular VD was also lower in S-NPDR group. In foveal, p=0.01.In parafoveal and perifoveal, p＜0.001. And FAZ area expanded in S-NPDR eyes(p=0.05). In S-NPDR eyes , at 3 months after PRP, foveal VD in DCP increased significantly(p=0.04). At 6 months after PRP, foveal VD increased both in SCP and DCP (P=0.01,P=0.008,respectively). At 6 months after PRP,FAZ area decreased (p=0.04).Conclusions : Patients with S-NPDR have retinal microcirculation disorder, and PRP can partially improve the macular microcirculation. VD and FAZ can be used as sensitive indicators for follow-up observation of diabetic retinopathy.

show abstract

Optical Coherence Tomography Angiography Assessment of Macular Choriocapillaris and Choroid Following Panretinal Photocoagulation in a Diverse Population With Advanced Diabetic Retinopathy

Zhao

Chen

et al. 2021

Asia-Pacific Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: The aim of this study was to evaluate choroidal and retinal microvasculature with optical coherence tomography angiography (OCTA) after panretinal photocoagulation (PRP) for diabetic retinopathy in a primarily Hispanic and Asian population. Design: Retrospective study. Methods: Eyes were examined by OCTA in the macula (3 × 3 mm) just before PRP treatment and 1 to 3 months afterwards. Choroidal thickness (CT) and central retinal thickness (CRT) were measured. Choroidal flow signal voids (CFSV) and choriocapillaris flow signal voids (CCFSV) were acquired. Retinal microvasculature parameters, including superficial and deep vessel density, superficial and deeper perfusion density, foveal avascular zone area, perimeter and circularity, were calculated. Ocular examinations and demographic information were analyzed. Results: CT at a location 1000 μm temporal to the fovea increased significantly after PRP (from 278.64 μm to 313.44 μm, P = 0.026). CCFSV increased slightly from (46.72 ± 8.52)% to (47.07 ± 10.77)%, but the difference was not statistically significant (P = 0.782). A similar finding was observed in CFSV (increase from 35.81% to 36.64%, P = 0.165). The change in all retinal microvasculature parameters was also not significant. Best-corrected visual acuity (BCVA) decreased from 0.218 ± 0.153 to 0.262 ± 0.147 (P = 0.034). Increased CRT (from 245.41 ± 33.18 μm to 251.14 ± 38.97 μm, P = 0.007) was observed. The change in CRT positively correlated with pre-PRP CRT (r = 0.434, P = 0.019) and BCVA reduction (r = 0.418, P = 0.024). Neither BCVA reduction nor CRT increase correlated with OCTA metrics. Conclusions: OCTA demonstrates redistribution of choroidal circulation from the periphery to the macula after PRP, with increased macular CT and stable choroidal blood flow density. Eyes with greater macular thickness are more likely to experience an increase in CRT.

show abstract

Retinal and Choroidal Perfusion Status in the Area of Laser Scars Assessed With Swept-Source Optical Coherence Tomography Angiography

Cited by 3 publications

References 32 publications

Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography

Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography

Effects of panretinal photocoagulation on macular vascular density and Foveal avascular zone area in patients with severe non-proliferative diabetic retinopathy by optical coherence tomography angiography

Optical Coherence Tomography Angiography Assessment of Macular Choriocapillaris and Choroid Following Panretinal Photocoagulation in a Diverse Population With Advanced Diabetic Retinopathy

Contact Info

Product

Resources

About