Retinal, Choroid, and Vitreous Humor Metabolism

Elliott, Richard L.; Teller, Richard; Beigelman, Paul M.

doi:10.1111/j.1755-3768.1965.tb07877.x

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…(1973) probably 'found' neuraminidase activity only in the vitreous of rats and rabbits, but not in those of pigs, humans and cattle. Likewise Elliot et al (1965) established C 0 2 production from "K-glucose only in the vitreous body of the rat but not in the rabbit or the dog.…”

Section: Discussionmentioning

confidence: 98%

Enzyme Activities and Protein Concentration in the Intraocular Fluids of Ten Mammals

Wurster

Riese

Hoffmann

1982

Acta Ophthalmologica

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An attempt was made to establish normal values for the total protein concentrations and the enzyme activities of LDH, MDH and PGI in the intraocular fluids of rats, guinea pigs, rabbits, cats, dogs, sheep, cattle, pigs, horses and humans. Remarkably little species differences were noted in 9 of the 10 mammals with vitreal enzyme activities falling into a narrow range between 8.4 U/l (PGI, horse) and 92.4 U/l (MDH, guinea pig). All species obeyed the sequence aqueous less than vitreous less than serum with exception of the rat, where vitreous activities surpassed serum at least two-fold. The very low enzyme activities in the aqueous and vitreous humors demand special precautions against contaminations which can either derive from post-mortem storage or inadequate sampling procedures. Conversely elevated enzyme activities could be used as probes for pathological processes or as a check for a clean preparation.

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Section: Discussionmentioning

confidence: 98%

Enzyme Activities and Protein Concentration in the Intraocular Fluids of Ten Mammals

Wurster

Riese

Hoffmann

1982

Acta Ophthalmologica

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“…The empty in the framework is filled with glycosaminoglycans and water [21]. Vitreous serves as a repository for metabolites exchange and nutrients transportation [22]. Meanwhile, it also acts as a support for intraocular lens and conduces to regulation [18].…”

Section: Biochemical Properties Of Vitreousmentioning

confidence: 99%

Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions

Wang¹,

Ran²,

Ma³

et al. 2021

Biomed. Mater.

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Vitreoretinal surgery is an essential approach to treat proliferative diabetic vitreopathy, retinal detachment, retinal tear, ocular trauma, and macular holes. The removal of the natural vitreous and the replacement with substitutes are critical steps for retina reattachment. Vitreous substitutes including silicone oil (SiO), air, sulfur hexafluoride (SF6), and perfluoropropane (C3F8), have been widely applied in clinical practice. However, these substitutes are reported to cause complications such as emulsification, high intraocular pressure, and lens opacification. Polymeric hydrogels are a kind of material with favorable physical, mechanical properties, and adaptable biocompatibility, thus being highly expected to be ideal vitreous substitutes. Despite years of research, very few polymeric hydrogels can be applied practically in the vitreous cavity. In this review, we focus on the development of polymeric natural-based hydrogels and synthetic hydrogels. Particularly, we pay attention to recent advances in the novel stimuli-response and self-assembly supramolecular hydrogels. Characterized by easy injectability and long residence time, this kind of hydrogel becomes the potentially promising candidates for ideal vitreous substitutes. Finally, we evaluate the current challenges and provide the future directions of vitreous substitutes.

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The physiology and pathophysiology of intraocular fluids

Bito

1977

Experimental Eye Research

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Retinal, Choroid, and Vitreous Humor Metabolism

Cited by 4 publications

References 6 publications

Enzyme Activities and Protein Concentration in the Intraocular Fluids of Ten Mammals

Enzyme Activities and Protein Concentration in the Intraocular Fluids of Ten Mammals

Polymeric hydrogel as a vitreous substitute: current research, challenges, and future directions

The physiology and pathophysiology of intraocular fluids

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