The physiology and pathophysiology of intraocular fluids

Bito, Laszlo Z.

doi:10.1016/s0014-4835(77)80024-9

Cited by 45 publications

(23 citation statements)

References 29 publications

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“…It is generally accepted that ascorbic acid is actively transported into the posterior cham ber while glucose transport can be either ac tive or passive at this site [7]. The ascorbic acid concentration in the vitreous is lower than that in the aqueous and decreases toward the retina.…”

Section: Discussionmentioning

confidence: 99%

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Intraocular Irrigating Solutions and Vitrectomy- Related Changes (in Protein, Lactic and Ascorbic Acid) in Rabbit Vitreous

Manzanas¹,

Pastor²,

Muñoz

et al. 1992

Ophthalmic Res

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Vitrectomy and the subsequent vitreous fluid exchange alter the chemical and physical properties of the vitreous. This study assessed the time course alterations of total protein, ascorbic acid and lactic acid in the rabbit vitreous cavity following vitrectomy. Normal values were 2.2 ± 1.2 mg/ml, 8.5 ± 1.0 mg/l00 ml and 16.8 ± 3.5 μmol/ml, respectively. Nine groups of 5–10 adult albino rabbits underwent closed vitrectomy using physiologic saline, Ringer’s lactate and BSS plus solutions. Samples were withdrawn at 3 and 24 h and 7 days after vitrectomy. Total protein levels increased in all groups at 3 and 24 h (20-30 mg/ml). Ascorbic acid measurements at 24 h rose only with saline and BSS plus. At 24 h the BSS plus group was the only one demonstrating an increased lactic acid concentration.

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Section: Discussionmentioning

confidence: 99%

“…the lens and the retina, depend on intraocular fluids for their meta bolic exchanges [7], Any abnormalities in the aqueous and vitreous humors can be expected to affect the surrounding intraocular tissues.…”

Section: Introductionmentioning

confidence: 99%

Intraocular Irrigating Solutions and Vitrectomy- Related Changes (in Protein, Lactic and Ascorbic Acid) in Rabbit Vitreous

Manzanas¹,

Pastor²,

Muñoz

et al. 1992

Ophthalmic Res

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“…There may have also been differences in study methods [89]. An obvious discrepancy may be the aspiration techniques adopted by some investigators [51].…”

Section: Between Eye Differencesmentioning

confidence: 99%

“…An obvious discrepancy may be the aspiration techniques adopted by some investigators [51]. The levels may vary based on different analytical procedures and instruments used, including sample manipulations before analysis [10,51,89]. Bito reported that the concentration of many solutes in the VH is different in anterior and posterior vitreous chambers [90].…”

Section: Between Eye Differencesmentioning

confidence: 99%

“…Consequently, it is essential to aspirate VH as completely as possible to most accurately reflect the concentration of all solutes [90]. The differences in findings may also be attributed to the instrumentation methods used in different studies as it has been suggested that the concentration of VH constituents will vary with different instruments [51,89].…”

Section: Between Eye Differencesmentioning

confidence: 99%

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Vitreous Humor: A Short Review on Post-mortem Applications

J¹

2015

J Clin Exp Pathol

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Vitreous humor has been investigated since the 1960s, with many debates occurring over the years with regard to the usefulness of its specific applications. The composition of several electrolytes in post-mortem vitreous humour has been extensively studied. Using the fluid for determining the cause of death has also become commonplace, including testing glucose levels of diabetic related deaths, as well as alcohol and drug related fatalities. The debate regarding the composition between two eyes of the same individual has been an issue in the past, but has since been resolved.

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