Retinal Degeneration in the nervous Mutant Mouse. III. Electrophysiological Studies of the Visual Pathway

Ren, Jian Ching; LaVail, Matthew M.; Peachey, Neal S.

doi:10.1006/exer.1999.0804

Cited by 26 publications

(22 citation statements)

References 28 publications

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“…Similar findings have been reported in other models of mouse retinal degeneration including the nervous mutant 30 rds heterozygotes 50 and a transgenic mouse with a triple substitution in the rhodopsin molecule. 51 Figure 4C shows that a number of the outer segments of surviving photoreceptors are shortened in the mcd/mcd retina.…”

Section: Discussionsupporting

confidence: 88%

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Progressive Age-Related Changes Similar to Age-Related Macular Degeneration in a Transgenic Mouse Model

Rakoczy

Zhang

Robertson

et al. 2002

The American Journal of Pathology

157

115

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Section: Discussionsupporting

confidence: 88%

“…30 The R max value (ϮSEM) of 370 Ϯ 29 V for mcd/mcd mice was significantly lower than the C57BL/6 mice value of 740 Ϯ 73 V (P Ͻ 0.005). Similarly, a significant reduction in retinal sensitivity of 0.85 log neutral density units was seen in mcd/mcd mice.…”

Section: Electroretinographymentioning

confidence: 79%

Progressive Age-Related Changes Similar to Age-Related Macular Degeneration in a Transgenic Mouse Model

Rakoczy

Zhang

Robertson

et al. 2002

The American Journal of Pathology

157

115

View full text Add to dashboard Cite

show abstract

“…Electroretinograms were recorded in response to strobe flashes presented in a Ganzfeld bowl under dark-and light-adapted conditions by using protocols described in detail previously (Ren et al, 2000;Ball et al, 2002). In separate sessions, visual evoked potentials were recorded by using a previously described technique (Ren et al, 2000).…”

Section: Visual Electrophysiologymentioning

confidence: 99%

Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System

Bjartmar

Huberman

Ullian

et al. 2006

Journal of Neuroscience

164

193

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Neuronal pentraxins (NPs) define a family of proteins that are homologous to C-reactive and acutephase proteins in the immune system and have been hypothesized to be involved in activity-dependent synaptic plasticity. To investigate the role of NPs in vivo, we generated mice that lack one, two, or all three NPs. NP1/2 knock-out mice exhibited defects in the segregation of eye-specific retinal ganglion cell (RGC) projections to the dorsal lateral geniculate nucleus, a process that involves activity-dependent synapse formation and elimination. Retinas from mice lacking NP1 and NP2 had cholinergically driven waves of activity that occurred at a frequency similar to that of wild-type mice, but several other parameters of retinal activity were altered. RGCs cultured from these mice exhibited a significant delay in functional maturation of glutamatergic synapses. Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal long-term potentiation and long-term depression, appeared normal in NP-deficient mice. These data indicate that NPs are necessary for early synaptic refinements in the mammalian retina and dorsal lateral geniculate nucleus. We speculate that NPs exert their effects through mechanisms that parallel the known role of short pentraxins outside the CNS.

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“…Ele está formado por sinais extraídos da atividade elétrica do córtex visual, após impulsos serem gerados em um campo visual central da retina, seguindo pelo nervo óptico, passando pelo corpo geniculado lateral, com radiação óptica até o córtex occipital (OYAMADA, 2000;SALOMÃO, 2007;ODOM et al, 2010). O PVE de varredura é comumente empregado para identificar disfunções no sistema visual, resultante de doenças desmielinizantes, neurite óptica, neuropatias isquêmicas e compressivas, além de servir como recurso para obtenção da Acuidade Visual (AV) em pacientes não verbais e não cooperativos, como crianças e animais (REN et al, 2000). Além de ser utilisado como ferramenta para o diagnóstico de neuropatias, o potencial visual evocado por padrão reverso (PVE-PR) com tabuleiro de xadrez serve como ferramenta para avaliar o impacto destas doenças sobre a função visual em seres humanos (JUERGEN et al, 2014).…”

Section: IIunclassified

Potencial visual evocado por padrão reverso com tabuleiro de xadrez em gatos domésticos adultos

et al. 2015

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RESUMO O potencial visual evocado por padrão reverso (PVE-PR) é um método objetivo, não invasivo e estabelecido para as investigações funcionais. Este trabalho teve como objetivo a obtenção de dados do PVE-PR com tabuleiro de xadrez em gatos (16', 32', 64', 130' e 260'de arco Palavras-chave: felinos, teste eletrofisiológico, oftalmologia. ABSTRACT The pattern reversal visual evoked potential (PR-VEP) is an objective method, stablished for noninvasive functional investigations. This research aimed to obtain data from the PR-VEP with checkerboard in adult domestic cats and the influence of different visual angles on the peak latency and implicit time ofwaves N75 and P100. It was used 13 adult cats (2-4 years old), of both sexes. Each animal was positioned 100 cm away from a video monitor located at 17.2º. The stimulus generated for the formation of wave VEPs was "square" with the frequency of 6Hz, presented in five spatial frequencies (16 ', 32', 64 ', 130' and 260 'of arc). Mean values of implicit times (ms) and amplitudes (µvolts) of P100were not statistically different and were not correlated (r=0.067

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Retinal Degeneration in the nervous Mutant Mouse. III. Electrophysiological Studies of the Visual Pathway

Cited by 26 publications

References 28 publications

Progressive Age-Related Changes Similar to Age-Related Macular Degeneration in a Transgenic Mouse Model

Progressive Age-Related Changes Similar to Age-Related Macular Degeneration in a Transgenic Mouse Model

Neuronal Pentraxins Mediate Synaptic Refinement in the Developing Visual System

Potencial visual evocado por padrão reverso com tabuleiro de xadrez em gatos domésticos adultos

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