Retinal haemorrhage rates and resolution time of retinal haemorrhage in newborns after hypothermic treatment for hypoxic–ischemic encephalopathy

Eriş, Erdem; Eris, D.; Seymen, Zeynep; Karasu, Buğra; Dıraçoğlu, Aynur; Perente, İrfan; Çömert, Serdar

doi:10.1016/j.arcped.2019.11.001

Cited by 8 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The prevalence of neonatal retinal hemorrhage in this study was 24.8%. This is comparable to the rates reported by some previous studies (20.2–24.5%) [ 8 , 22 , 30 , 32 , 34 ], but significantly higher than those reported by other studies (2.4–14.5%) [ 9 , 26 , 27 , 35 , 36 , 37 ], and lower than those reported by others (34–39.4%) [ 4 , 6 , 20 , 25 , 31 ]. Despite attempts to explain the reasons for these significant differences, no statistically proven explanation has been provided.…”

Section: Discussionsupporting

confidence: 91%

“…Considering the prevalence, characteristics, and risk factors of RH is important for disease management. Previous studies based on non-neonatal digital wide-field fundus imaging systems have been conducted [ 1 , 4 , 6 , 9 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Emerson investigated the prevalence and disappearance rate of retinal hemorrhage in 149 healthy neonates using indirect ophthalmoscopy and found that 34% of the subjects had retinal hemorrhage of varying severity [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence, Characteristics, and Risk Factors of Retinal Hemorrhage among Full-Term Neonates in Southern China

Yang

Chen

et al. 2022

IJERPH

View full text Add to dashboard Cite

Neonatal retinal hemorrhage (RH) is the most common ocular fundus disease among newborns. Early detection and timely intervention are vital for reducing the risk of visual impairment caused by RH. However, little is known about the prevalence, characteristics, and risk factors of RH in southern China. Full-term infants born in Qingyuan City during the first 10 days of each month in 2021 were included in this study. All infants underwent RetCam III retinal examinations. Detailed information on retinal hemorrhage, including involved eyes, bleeding severity, and affected area (extrafoveal macula, fovea, or optic disc), and clinical information on the neonates and their mothers was collected. The results showed that among the 1072 eligible neonates, 266 (24.8%) had neonatal retinal hemorrhage. Consistent bilateral retinal hemorrhage severity was observed in 83.2% of the cases. The prevalence of optic disc involved RH, extrafoveal macular involved RH and foveal involved RH were 23.7%, 81.2% and 2.63%, respectively. Multivariate logistic regression analysis showed that lower birth weight (OR, 0.63; 95% CI, 0.40–0.99; p < 0.05) and vaginal delivery (OR, 20.6; 95% CI, 9.10–46.5; p < 0.001) were risk factors of neonatal RH. The area under the ROC curve of vaginal delivery, combined with birth weight, as predictors of neonatal RH was 0.73, with 85.3% sensitivity and 23.9% specificity. The birth weight cutoff was 3460 g. Our results suggested that neonatal RH is common in full-term neonates in southern China. It usually has the same severity in both eyes and mostly involves the extrafoveal macular region. Vaginal delivery and low birth weight are risk factors for neonatal RH.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Prevalence, Characteristics, and Risk Factors of Retinal Hemorrhage among Full-Term Neonates in Southern China

Yang

Chen

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…The data also shows that retinal hemorrhages that are “dense, extensive, covering a large surface area, and/or extending to the ora serrata.” are common and occur relatively commonly in non-AHT. This supports a growing body of research [ [28] , [29] , [30] , [31] , [32] , [33] , [34] ] that has shown that severe retinal hemorrhages in infants can have a range of causes. The known relation between severity of intracranial pathological conditions and rates of severe retinal hemorrhages is also found in the pediBIRN data and seems to be a very robust relation.…”

Section: Discussionsupporting

confidence: 76%

Evidence for significant misdiagnosis of abusive head trauma in pediBIRN data

Brook

2023

Forensic Science International: Synergy

View full text Add to dashboard Cite

“…Particularly, the external pressure exerted during forceps-assisted vaginal delivery further elevates retinal venous pressure, thereby increasing the likelihood of retinal hemorrhage [20]. Concurrently, administration of uterine contraction agents during vaginal delivery can stimulate the release of additional prostaglandins in neonates, thereby compromising the blood-retina barrier and resulting in retinal hemorrhage [21]. The incidence of RH in cesarean section is low due to the absence of compression from the birth canal and external forces, as well as stable hormone levels.…”

Section: Discussionmentioning

confidence: 99%

Risk factors of retinal hemorrhage among full-term newborns in Anhui Province of China: a retrospective study

Huang,

Wang,

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Neonatal fundus disease lacks typical symptoms, thus early identification and prompt treatment are crucial for preventing visual dysfunction. This study aimed to identify the factors influencing the severity of retinal hemorrhage. Methods A total of 507 full-term newborns who underwent fundus disease screening at Suzhou Municipal Hospital from January 2023 to July 2023 were enrolled in this study. All full-term newborns underwent fundus examination using RetCam III shuttle within 7 days of birth, and clinical information on the newborns and their mothers was collected. Univariate and multivariate regression analyses were employed to identify independent risk factors and develop clinical risk nomogram. The risk nomogram was developed using the rms package and evaluated using decision curve analyses. Results Among the 507 newborns included in the study, a total of 210 cases exhibited fundus abnormalities. Retinal hemorrhage was identified as the most prevalent fundus abnormality (75.71%), followed by familial exudative vitreoretinopathy (14.76%) and retinopathy of prematurity (3.8%). Univariate and multivariate analysis demonstrated that vaginal delivery (OR = 4.875), binocular hemorrhage (OR = 6.434), and macular involvement (OR = 3.932) as independent risk factors for severe retinal hemorrhage. The C-index of the nomogram model was 0.804, with AUC of the ROC curve at 0.804 (95%CI, 0.733–0.875). The decision curve analysis indicated clinical risk nomogram has application value. Conclusion Vaginal delivery, binocular hemorrhage and macular involvement are risk factors for neonatal retinal hemorrhage. The clinical risk model can effectively predict the severity of neonatal retinal hemorrhage.

show abstract

Retinal haemorrhage rates and resolution time of retinal haemorrhage in newborns after hypothermic treatment for hypoxic–ischemic encephalopathy

Cited by 8 publications

References 19 publications

Prevalence, Characteristics, and Risk Factors of Retinal Hemorrhage among Full-Term Neonates in Southern China

Prevalence, Characteristics, and Risk Factors of Retinal Hemorrhage among Full-Term Neonates in Southern China

Evidence for significant misdiagnosis of abusive head trauma in pediBIRN data

Risk factors of retinal hemorrhage among full-term newborns in Anhui Province of China: a retrospective study

Contact Info

Product

Resources

About